CDX2 Antibody Clone: GR023 Concentrate
- Known as:
- CDX2 Antibody Clone: GR023 Concentrate
- Catalog number:
- 61-0186
- Product Quantity:
- 1 mL
- Category:
- -
- Supplier:
- Genemed
- Gene target:
- CDX2 Antibody Clone: GR023 Concentrate
Related genes to: CDX2 Antibody Clone: GR023 Concentrate
- Gene:
- CDX2 NIH gene
- Name:
- caudal type homeobox 2
- Previous symbol:
- CDX3
- Synonyms:
- -
- Chromosome:
- 13q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-09-07
- Date modifiied:
- 2015-08-24
Related products to: CDX2 Antibody Clone: GR023 Concentrate
Related articles to: CDX2 Antibody Clone: GR023 Concentrate
- Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome (MCLS), remains the leading cause of acquired heart disease in children younger than 5 years; coronary artery lesions (CALs) develop in 20-30% of untreated patients. Although environmental exposures have been implicated, evidence is inconclusive, and systematic analyses linking exposure profiles to KD-associated immune signatures are still lacking. Despite rising global incidence, the etiology remains unclear, and systematic exploration of potential associations between environmental exposure and KD immune signatures is insufficient. This study employed integrated multi-omics analysis to explore potential associations between perfluorooctane sulfonate (PFOS) exposure and KD immune transcriptomic signatures. By intersecting KD transcriptomic signatures with PFOS toxicological targets, we identified 83 candidate genes significantly enriched in immune-inflammatory pathways. Permutation testing demonstrated PFOS-specific enrichment compared with structurally related compounds (enrichment fold = 2.45; P < 0.001). Machine learning combined with SHAP analysis identified four candidate hub genes (ALPL, IL4R, PGD, SLC22A4) showing consistent expression patterns across independent cohorts. Computational molecular simulations predicted potential binding interfaces between PFOS and candidate proteins, with more favorable docking scores compared to non-fluorinated analogs (6.4-8.9 kcal/mol). Single-cell RNA sequencing revealed hub gene expression in CD14/CD16 Mono and CD8 T, which exhibited elevated PFOS response scores. Transcription factor network analysis predicted CEBPB and CDX2 as candidate regulators associated with hub gene expression, with their regulatory activities correlated with PFOS response scores (activity differences and score-dependent monotonic trends; both P < 2.2 × 10). These computational findings suggest potentially PFOS-associated transcriptomic signatures in KD, providing candidate targets for subsequent mechanistic validation and epidemiological studies. - Source: PubMed
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Quan JiaTu JuxiangLi DanZhang ZongliXue LishaLi TaoXi Shibing - Wnt/β-catenin-activated rosette-forming carcinoma (WARFC) is a recently proposed cutaneous tumor entity characterized by rosette formation, CDX2 expression, RB1 loss, and Wnt/β-catenin pathway activation. Extracutaneous counterparts of WARFC have not been documented to date. We report a distinctive case of lung carcinoma closely resembling WARFC. An 80-year-old man with a smoking history presented with a rapidly enlarging lung nodule. The resected tumor consisted of a rosette-forming large cell carcinoma with a trabecular pattern and lacking neuroendocrine marker expression, combined with squamous cell carcinoma. The rosette-forming component showed aberrant nuclear β-catenin expression, diffuse CDX2 expression, and RB1 loss. Targeted sequencing identified a pathogenic APC splice-site mutation. This case likely represents the pulmonary counterpart of cutaneous WARFC. Pulmonary WARFC should be considered in the differential diagnosis of large cell lung carcinoma with neuroendocrine morphology. - Source: PubMed
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