Capp pipette, fixed vol. 5 ml, Bravo
- Known as:
- Capp pipette, fixed vol. 5 milliliter, Bravo
- Catalog number:
- B5000-1F *
- Category:
- -
- Supplier:
- Capp
- Gene target:
- Capp pipette fixed vol. 5 Bravo
Ask about this productRelated genes to: Capp pipette, fixed vol. 5 ml, Bravo
- Gene:
- NRCAM NIH gene
- Name:
- neuronal cell adhesion molecule
- Previous symbol:
- -
- Synonyms:
- KIAA0343, Bravo
- Chromosome:
- 7q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-19
- Date modifiied:
- 2016-10-05
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- : Clinical outcomes after traumatic brain injury (TBI) remain difficult to predict, highlighting the need for more sensitive diagnostic and prognostic biomarkers, particularly in polytrauma. This study aimed to identify TBI-specific proteomic signatures in plasma and extracellular vesicles (EV)-enriched fractions of critically injured trauma patients. : Seventy-five severely injured adult trauma patients (ISS ≥ 16) were included: isolated severe TBI (TBI; AIS ≥ 4, other AIS ≤ 1, = 23), polytrauma with TBI (PT-TBI; AIS ≥ 4, = 22), and polytrauma without TBI (PT; AIS = 0, = 30). 24 age- and sex-matched healthy volunteers served as controls. Neat plasma and EV-enriched fractions were profiled using HPLC-MS/MS. Differentially expressed proteins (DEP) were analyzed bioinformatically, and associations with clinical parameters were assessed using Spearman's correlation. : The EV-enriched plasma fraction yielded more DEPs than neat plasma (846 vs. 258). Most DEPs were linked to polytrauma, with plasma reflecting metabolism and EVs showing translation and protein catabolism signatures. Among TBI-context proteins, EV-associated NRCAM and AQR and plasma IGHV1-69D, MASP1, PON1, and IGFBP7 remained significantly associated with TBI after adjustment for confounder. Notably, only EV-associated proteins correlated with injury-related clinical parameters. AQR negatively correlated with GCS ( = -0.51, < 0.0001), while elevated NRCAM, AQR, and plasma MASP1 were associated with neurological deterioration and neurosurgical intervention. : EV-enriched plasma proteomics enhances biomarker discovery in polytrauma, revealing distinct pathways and greater sensitivity than whole plasma. While most changes reflect systemic injury, EV-associated NRCAM and AQR, along with plasma MASP1, show TBI-specific associations with neurological status, highlighting their potential as candidate TBI biomarkers for further study. - Source: PubMed
Publication date: 2026/07/25
Leppik LiudmilaWeber BirteSchindler Cora RFunda LouiseKrüger MarcusProschinger SebastianHenrich DirkMarzi Ingo - Over the past decade, the prognosis of patients with metastatic renal cell carcinoma (mRCC) has significantly improved owing to the development of anti-angiogenic targeted drugs such as sunitinib, pazopanib, and sorafenib. However, biomarkers that can identify patients with mRCC who may rapidly develop drug resistance are still lacking. Approximately 25% of patients experience rapid disease progression [progression-free survival (PFS) ≤3 months]. Currently, there is a lack of effective noninvasive biomarkers to identify resistant patients prior to treatment. This study aimed to identify plasma biomarkers associated with therapeutic resistance and develop a predictive model for clinical decision-making. - Source: PubMed
Publication date: 2026/06/25
Gan XinxinYan RuiYang BoWang JieGuo JianmingWang XiangHu XiaoyiWang LinhuiLiu Bing - This study aimed to investigate the causal associations and potential mechanistic pathways involving pulse rate, neuronal cell adhesion molecule (NrCAM), migraine, and other neurological disorders within the context of the glymphatic system. - Source: PubMed
Publication date: 2026/07/29
Hou WeiyuHou Weiming - - Source: PubMed
Publication date: 2026/06/20
Yu ChenshiLiu LiuLu ZhehangChen MinxiaYang NaLi ZongyuanBai LuowenLi ChangyuZhou Xiaojie - Astrocytic activation is critically involved in the development and maintenance of bone cancer pain (BCP). Recent studies have shown that astrocytes participate in synaptic remodeling through synaptic phagocytosis, whereas neuronal cell adhesion molecule (NRCAM) restricts the extension of perisynaptic astrocytic processes and exerts an anti-phagocytic effect. However, whether astrocyte-mediated synaptic phagocytosis contributes to BCP remains to be explored. Hence, this study investigated the role of astrocytic NRCAM deficiency in synaptic remodeling and central sensitization in BCP. - Source: PubMed
Publication date: 2026/06/05
Zhang ZuoxiaHou YunfanMao YantingJiang LiLu Cui'eYu JiachengHuang YulinXu RuiHuang SiminZhang XiaoZhu HuijieZhang WeiSun Yu'eMa Zhengliang