BCA-1 CXCL13, Human
- Known as:
- Bicinchoninic acid-1 CXCL13, Human
- Catalog number:
- Z02826-20
- Product Quantity:
- 20,0μg
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- BCA-1 CXCL13 Human
Related genes to: BCA-1 CXCL13, Human
- Gene:
- ABCA11P NIH gene
- Name:
- ATP binding cassette subfamily A member 11, pseudogene
- Previous symbol:
- ABCA11
- Synonyms:
- EST1133530, FLJ14297
- Chromosome:
- 4p16.3
- Locus Type:
- pseudogene
- Date approved:
- 1999-06-11
- Date modifiied:
- 2015-11-13
- Gene:
- CXCL13 NIH gene
- Name:
- C-X-C motif chemokine ligand 13
- Previous symbol:
- SCYB13
- Synonyms:
- BLC, BCA-1, BLR1L, ANGIE, ANGIE2
- Chromosome:
- 4q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-09-05
- Date modifiied:
- 2016-10-05
Related products to: BCA-1 CXCL13, Human
Related articles to: BCA-1 CXCL13, Human
- Peripheral T-cell lymphoma (PTCL) is a heterogeneous and highly aggressive subtype of non-Hodgkin lymphoma. Approximately 30% of patients develop relapsed or refractory PTCL (R/R PTCL) due to disease recurrence or failure to achieve complete remission after first-line therapy. Despite therapeutic advances, the molecular and cellular mechanisms underlying treatment resistance in R/R PTCL remain unclear. - Source: PubMed
Publication date: 2026/07/10
Zhang NingYu JingweiLiu HengqiHu ZechaoMeng ShenSun CongLu YaxiaoLiu XiaSong ZhengLi LanfangQiu LihuaQian ZhengziMeng BinGong WenchenZhou ShiyongWang XianhuoZhang Huilai - Colorectal cancer (CRC) is one of the most commonly occurring cancers all over the world. Because of the high metastasis rate, the 5-year survival rate of metastatic CRC is only around 10%. CRC cells trigger the remodeling of the tumor microenvironment (TME), so decoding the TME between metastatic and primary sites becomes crucial. - Source: PubMed
Publication date: 2026/05/12
Zhao ZhixunChen HaipengGuan XuJiang ZhengLiu ZhengYang MingLiu HengchangChen TianliZou ShuangmeiGao YiboWang Xishan - Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy, representing 80-90% of kidney cancer cases. This study aimed to identify potential prognostic genes to improve patient survival prediction and provide new insights into the pathogenesis and treatment of ccRCC through comprehensive whole transcriptome sequencing analysis. - Source: PubMed
Publication date: 2026/07/08
Chang PengchengQin ZitongLiu RunzhangWang BinxianLu HuaiquanJing SuoshiGuo ChenhaoLi Weiping - The organization of diverse mesenchymal populations during human small intestinal development is critical for tissue architecture and function yet remains poorly defined. Here, to construct a comprehensive, tissue-scale map of the developing human small intestine at single cell resolution, we leveraged single-cell RNA-sequencing data to build a Xenium spatial transcriptomics gene panel covering the cell diversity of the human small intestine. We defined five subpopulations occupying discrete anatomical locations within the lamina propria and submucosa-the subepithelial cells, lamina propria fibroblasts, submucosal fibroblasts, smooth muscle cells and CXCL13 fibroblasts. Our data establish molecular markers to distinguish these populations in both sequencing and imaging data. We leverage this high-resolution atlas to interrogate cell-cell signalling, benchmark pluripotent stem cell-derived human intestinal organoids and to demonstrate how this resource can incorporate relative spatial organization into tissue analysis, with broad implications for modelling development, regeneration and disease. - Source: PubMed
Publication date: 2026/07/22
Johnson Kelli FDong XiangningTsai Yu-HwaiWu AngelineClark Sydney GVallie AbigailHuang ShaChilds Charlie JZwick Rachel KGlass IanWalton Katherine DKlein Ophir DSpence Jason R - The intratumoral microbiome has recently emerged as a potential hallmark of cancer, with implications for response or resistance to therapy. Bacteria can either promote or inhibit cancer growth. However, intratumoral bacteria can also be engineered using synthetic biology to remodel the tumor microenvironment. Here, we engineered the probiotic bacterium Nissle 1917 (EcN) to express the human chemokine CXCL13 (C-X-C motif chemokine ligand 13), a critical component of germinal center (GC) formation. Antibody affinity maturation and class switching are fundamental aspects of adaptive immune response. Both occur primarily in the GCs of secondary lymphoid organs for defense against pathogens. Immune checkpoint blockade (ICB) efficacy is primarily driven by T cells; however, recent studies in mice and humans have shown that humoral immune responses act as critical partners for ICB-mediated antitumor activity. Using orthotopic models of bladder cancer, intravesically delivered engineered CXCL13-expressing EcN colonized bladder tumors and elicited GC responses in bladder tumor-draining lymph nodes after intravesical delivery. When combined with programmed cell death protein 1 (PD-1) blockade, engineered EcN improved antitumor activity in two aggressive, fast-growing, and immunologically cold orthotopic mouse models of bladder cancer. Mechanistically, this antitumor effect was dependent on the presence of CD8 T cells and CD4 T follicular helper cells; combination therapy increased tumor-specific antibody responses and promoted long-term survival and protective immunity upon tumor rechallenge. Thus, we demonstrate that synthetically engineered CXCL13-expressing EcN can enhance the efficacy of PD-1 checkpoint blockade immunotherapy by amplifying tumor-specific humoral immunity. - Source: PubMed
Publication date: 2026/07/22
Rouanne MathieuChen NoahMariuzza Dylan LYang ZaofengLi Fangdade Los Santos-Alexis KeniaSavage Thomas MVincent Rosa LMendelsohn Cathy LDanino TalArpaia Nicholas