AdipoR1 Blocking Peptide target: AdipoR1
- Known as:
- AdipoR1 Blocking Peptide target: AdipoR1
- Catalog number:
- 3940BP-50
- Product Quantity:
- 50 μg
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- AdipoR1 Blocking Peptide target:
Related genes to: AdipoR1 Blocking Peptide target: AdipoR1
- Gene:
- ADIPOR1 NIH gene
- Name:
- adiponectin receptor 1
- Previous symbol:
- -
- Synonyms:
- PAQR1, ACDCR1
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-23
- Date modifiied:
- 2018-05-03
Related products to: AdipoR1 Blocking Peptide target: AdipoR1
Related articles to: AdipoR1 Blocking Peptide target: AdipoR1
- Periodontitis is a chronic inflammatory disease which is initiated by dysbiotic biofilms and maintained by a host who is permissive to inflammation resulting in continuous destruction of periodontal supporting structures. Periodontitis occurs frequently with obesity and type 2 diabetes mellitus and the broader cardiometabolic risk state leading to investigations into the common immunometabolic pathways that link these conditions. Adiponectin, an insulin sensitizing and anti-inflammatory adipokine which can also act as a vasculoprotective and bone-related factor, has been studied as a potential modulator of the relation between periodontal inflammation and systemic metabolic disturbance. This narrative review summarizes the biology of adiponectin and its receptors, human findings relating to both the local and circulating forms of adiponectin in periodontal health and disease, the mechanism in cell and animal models and translational implications and limitations. The literature was reviewed in a narrative manner with particular attention to study quality, compartment-specific biology and any conflicts in evidence and the difference between biological plausibility and clinical relevance. A tendency for a reduction in the circulating, saliva and gingival crevicular fluid levels of adiponectin in periodontitis in human studies, particularly those with co-existing obesity and type 2 diabetes mellitus, can be demonstrated but these finding are often disparate due to variable methods in case definitions, assay techniques, metabolic background of subjects and other confounders. Experimental findings may establish biological plausibility by linking adiponectin signalling with the mechanisms which affect inflammatory responses, endothelial function and matrix homeostasis, osteoclastogenesis and subsequent alveolar bone loss, although adiponectin signalling appears context-specific in its actions and this does not confirm clinical relevance. Evidence suggests adiponectin is a biologically significant, but context-dependent factor within the immunometabolic network which connects periodontal disease with the systemic condition, rather than a sole marker or clinically recognized target for therapeutic intervention. - Source: PubMed
Publication date: 2026/05/08
Mochol MartynaDura WłodzimierzLodigkeit MaikeAndrzejewski PiotrLipski MariuszMazurek-Mochol Małgorzata - Microbiota-derived metabolites are increasingly recognized as modulators of systemic immunity and cancer biology. This study investigates how a structurally distinct lipid from Akkermansia muciniphila influences immune transcriptional programs and their connection to breast cancer (BRCA)-associated pathways. - Source: PubMed
Chaudhary UmaA S AryaA Mythili - Adiponectin (APN) is a multifunctional adipokine secreted by adipose tissue that has recently been recognized for its important neuroprotective effects in central nervous system (CNS) disorders. However, effective targeted interventions and the precise molecular mechanisms of APN and its receptors remain incompletely understood. Activation of cerebral APN receptor 1 (AdipoR1) through APN supplementation, APN receptor agonists, or exercise interventions can exert beneficial effects in CNS disorders. These effects are mediated through signaling pathways such as AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-alpha (PPARα), leading to enhanced insulin sensitivity, promotion of autophagic clearance of toxic substances, attenuation of neuroinflammation, reduction of oxidative stress and neuronal apoptosis, and improvement of mitochondrial function. This review summarizes the mechanistic associations between APN and various CNS disorders and analyzes the specific intervention strategies, mechanisms, and therapeutic potential of different APN isoforms, APN receptor agonists, and exercise targeting APN receptors. It provides a theoretical basis for exploring effective therapeutic strategies for CNS disorders. In addition, based on the theoretical rationale that both exercise and APN receptor agonists can independently activate the AdipoR1 signaling pathway, future studies may further explore the synergistic effects and potential value of their combined application, thereby providing new research perspectives for promoting brain health. - Source: PubMed
Publication date: 2026/05/21
Li MingmingWu MinGao HaoyangXue XiangliXiao WeihuaZhu Lin - Sleep deprivation is a common phenomenon in modern society and has received widespread attention. However, data about its impact on immune system functions remains scant. - Source: PubMed
Publication date: 2026/05/07
Li XiangWang XiaoyanWang XiaodiBing Dan - This study aimed to identify potential genetic variants and candidate genes associated with feed efficiency (FE), production, and feeding behaviour traits in Canadian purebred Duroc pigs. Genome-wide association studies (GWAS) were conducted using 8,861 individuals and an imputed Affymetrix PigGen Canada 50K panel v2.0 using a linear mixed model (LMM) and a Bayesian B model. This analysis used an adjusted p-value threshold (ranging from 6.6 × 10-5 to 1.3 × 10-4) using false-discovery rate to determine significance. The number of significant SNPs identified for each trait was as follows: average daily gain (ADG, 48), daily feed intake (DFI, 85), feed conversion ratio (FCR, 101), residual feed intake (RFI, 37), residual gain (RG, 64), residual intake and gain (RIG, 55), backfat thickness (BF, 100), loin depth (LD, 6), Keibler ratio (KR, 0), total time spent eating per day (TPD, 7), and number of visits to the feeder per day (NVD, 6). Several traits (BF, DFI, FCR, RFI, RG, and RIG) showed strong overlapping signals on chromosomes 7 and 10 with 24 shared significant SNPs, indicating potential shared genetic mechanisms. These traits also had 71 overlapping candidate genes such as PACSIN1, PTCH1, ADIPOR1 and ITPR3, associated with glucose, lipid and cholesterol metabolism. Well known candidate genes in literature associated with growth and fatness such as MC4R and CDH20 were also identified to be associated with ADG, BF, FCR and DFI in this study. Gene Ontology enrichment analysis revealed a set of the candidate genes were involved in the gonadotropin-releasing hormone (GnRH) and the platelet-derived growth factor (PDGF) signaling pathways. Overall, this study contributed to understating the genetic architecture and provided a biological foundation for improving FE, production and feeding behaviour traits in Canadian Duroc pigs facilitating the selection of more efficient pigs. - Source: PubMed
Publication date: 2026/05/09
Kim BelleDo Duy NgocJafarikia MohsenTulpan DanAdewole DeborahManafiazar GhaderSullivan BrianHoll JustinMiar Younes