DNMT3b Blocking peptide target: DNMT3b
- Known as:
- DNMT3b Blocking short protein sequence target: DNMT3b
- Catalog number:
- 3275BP-50
- Product Quantity:
- 50 μg
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- DNMT3b Blocking peptide target:
Related genes to: DNMT3b Blocking peptide target: DNMT3b
- Gene:
- DNMT3B NIH gene
- Name:
- DNA methyltransferase 3 beta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 20q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2019-04-23
Related products to: DNMT3b Blocking peptide target: DNMT3b
Related articles to: DNMT3b Blocking peptide target: DNMT3b
- Epigenetic-related genes (ERGs) play a pivotal role in cancer development and progression. However, their potential for cervical cancer (CC) diagnosis and prognosis remains underexplored. - Source: PubMed
Publication date: 2026/07/03
Lin XuefenZheng JianfengLi YanhongWang SipingLiu QinyingChen LijunLi SangSun Yang - Skin aging results from intrinsic factors and extrinsic stressors, particularly ultraviolet (UV) radiation, leading to structural and functional deterioration. Low-Level Laser Therapy (LLLT) has emerged as a potential non-invasive intervention. To evaluate the effectiveness of LLLT in mitigating UV-induced aging in human dermal fibroblasts (HDFs). HDFs were exposed to UV-A (365 nm) and red light (650 nm), individually or sequentially. Cell viability and proliferation were assessed via (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay and flow cytometry. Gene expression of collagen synthesis (Col1A1), apoptosis (Bax, Bcl2, Casp8), and DNA methylation (Dnmt3b) were analyzed by qPCR. UV irradiation reduced cell viability temporarily at 24 h, and subsequent treatment with red light after UV-A (UL group) resulted in partial recovery. The percentage of S-phase cells was higher in the UL group at 72 h (P < 0.05), suggesting an increased proliferative activity in this group. Expression of Col1A1 and Dnmt3b increased (P < 0.05, P < 0.01), while apoptotic markers were altered (P < 0.05, P < 0.01), suggesting enhanced collagen production, epigenetic regulation and reduced apoptosis. LLLT is a promising non-invasive approach to counteract UV-induced skin aging and support dermal regeneration. Further studies are required to optimize treatment protocols and validate clinical applications in dermatology and regenerative medicine. - Source: PubMed
Publication date: 2026/07/02
Dehkordi Elham MardanianFereidounian Mohammad AminBourBour ShahriarShirkavand AfshanYahoo QaemFarivar Shirin - This work aims to analyze the intricate process via which CBFβ-MYH11 facilitates the suppression of hepatocellular carcinoma in hypoxic environments. - Source: PubMed
Publication date: 2026/06/15
Ruan HongxunHuang WeiFang YanleXie LingQin Xiaoning - While emerging evidence highlights the importance of DNA methyltransferase 3B (DNMT3B) in cardiovascular pathophysiology, its precise role in thoracic aortic aneurysm and dissection (TAAD) remains poorly understood. Here, we elucidate the function and underlying mechanisms of DNMT3B in TAAD pathogenesis. We found that DNMT3B expression was markedly downregulated in vascular smooth muscle cells (VSMCs) of both human and mouse TAAD tissues compared to healthy controls. In vivo, targeted overexpression of DNMT3B in VSMCs via adeno-associated virus delivery significantly decreased TAAD incidence, reduced aortic rupture rates, and attenuated aortic dilation. Conversely, VSMC-specific DNMT3B knockdown exacerbated disease progression. In vitro experiments, utilizing adenovirus-mediated overexpression and the inhibitor Nanaomycin A revealed that DNMT3B inhibits both VSMC autophagy and phenotypic switching. Mechanistically, DNMT3B prevents the maladaptive transition of VSMCs toward a synthetic phenotype through the transcriptional repression of transcription factor EB (TFEB), thereby curbing excessive autophagy. Collectively, our findings demonstrate a protective role for DNMT3B against TAAD, highlighting its function in preserving VSMC homeostasis via the transcriptional inhibition of TFEB. - Source: PubMed
Publication date: 2026/06/24
Bao YulinZhu YaxinNiu YutingHu YiluLu DingkunXu RuixiaFan Xiaohan - Age-related cataract (ARC) is a degenerative change following the aging of the lens, with its specific pathogenesis still unclear. This study investigates the expression of GSK-3β, DNMT3B, and GJA3 in ARC through in vivo and in vitro studies, elucidating the regulatory mechanisms among them. Additionally, it preliminarily explores the role of DNMT3B in the epigallocatechin gallate (EGCG)-mediated delay of apoptosis in lens epithelial cells (LECs). Immunohistochemistry and Western blot results showed that the protein expression level of DNMT3B was elevated, while the protein expression levels of GJA3 and p-GSK-3β (Ser9) were decreased in the ARC group and the aged mouse group (P < 0.05). CCK-8 and Hoechst 333,42 apoptosis assays indicated that DNMT3B, GJA3, and p-GSK-3β (Ser9) were involved in HO-induced apoptosis of LECs. Further investigation revealed that DNMT3B regulates lens epithelial cell apoptosis by modulating GJA3 expression, and the expression of DNMT3B is regulated by GSK-3β. Additionally, we found that EGCG effectively alleviates DNMT3B-mediated apoptosis of LECs (P < 0.05). In summary, our study indicates that p-GSK-3β, DNMT3B, and GJA3 play significant roles in ARC and oxidative stress-induced apoptosis of LECs, with interrelated regulatory mechanisms. EGCG can target DNMT3B to reduce apoptosis in LECs, offering a new direction for the development of cataract treatments. - Source: PubMed
Publication date: 2026/06/18
Chen XiaoyaSu DongmeiZhang GaoboXiang ZihanFu YanjiangSun ZhaoyiHu YuzhuLi SijiaZhang YueMa XuHu ShanshanWei Qianqiu