FOXP2, affinity purified antibody, goat, 100 ug.
- Known as:
- FOXP2, antigenic enriched (anti-), caprine, 100 ug.
- Catalog number:
- GT41022-100
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- FOXP2 affinity purified antibody goat 100 .
Related genes to: FOXP2, affinity purified antibody, goat, 100 ug.
- Gene:
- FOXP2 NIH gene
- Name:
- forkhead box P2
- Previous symbol:
- TNRC10, SPCH1
- Synonyms:
- CAGH44
- Chromosome:
- 7q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-11-20
- Date modifiied:
- 2016-10-05
Related products to: FOXP2, affinity purified antibody, goat, 100 ug.
Related articles to: FOXP2, affinity purified antibody, goat, 100 ug.
- The development of musical abilities, including absolute pitch, musical memory, rhythm sense, and musicality, at a high degree is determined by a hereditary component (up to 68 %). The studies implementing a genome-wide linkage and association approach to musical aptitude have revealed more than 100 genetic loci. This spectrum is comprised of the genes encoding for transcription factors and those responsible for neurogenesis and synaptic plasticity, genes fixed as a result of positive selection of musicality, and those related to inner ear formation. Since no studies linking musical aptitude with genes have been previously conducted in Russia, the present study aimed at replicating the association of 17 previously identified genetic variants with developing musical abilities in Russians. Genotyping of SNPs in the GATA2, PCDH7, UNC5C, ASAP1, SBSPON, DCBLD2, KALRN, VLDLR, OTOF, GRIN2B, FoxP1, FoxP2, BDNF, EGR1, and SNCA genes was performed using competitive allele-specific PCR in a sample of students who underwent rigorous contest selection at admission to the conservatory and in the corresponding control group. A series of logistic regression analyses were used both to evaluate the main effect of SNP and to identify the best prognostic model based on various loci. The mathematical model obtained by including only statistically significant SNPs consisted of GATA2 rs9854612, SNCA rs356168, rs3910105, ASAP1 rs3057, and VLDLR rs1454626 (р = 0.0018, pseudo r2 = 0.188, AUC = 0.791). The addition of all examined SNPs as predictors enabled the construction of a statistically significant model with a higher predictive ability (р = 0.012, pseudo r2 = 0.380, AUC = 0.889). The results revealed indicate a potential cumulative gene effect, confirming the involvement of dopaminergic and GABAergic neurotransmission, the reelin pathway and the role of alpha-synuclein in musicality formation. - Source: PubMed
Kazantseva A VToropova A VKhusnutdinova E KMalykh S B - The parabrachial nucleus (PB) contains many neuronal subpopulations, including a cold-activated subset that relays thermosensory information to the forebrain. Although these neurons are part of the -derived PB macropopulation, their precise genetic identity has remained unclear, limiting cell-type-specific investigation of cold-defense circuitry. In this study, we show that this subpopulation is selectively identified by co-expression of and . This intersectional molecular identity suggests a practical strategy for selectively targeting cold-activated PB neurons, enabling cell-type-specific dissection of the circuit mechanisms underlying autonomic and behavioral cold-defense responses. - Source: PubMed
Publication date: 2026/05/27
Grady Fillan SLeaung Mya LGasparini SilviaZhu HaidongGeerling Joel C - The dorsal striatum is important for highly specialized functions including movement, learning, and habit formation. However, it is not known if species-specialized behaviors are associated with cellular specializations in the striatum. Here, we compared single-nucleus RNA sequencing (snRNA-seq) data from human, chimpanzee, rhesus macaque, common marmoset, and pale spear-nosed bat caudate (CN) and putamen (Pu) separately as well as mouse caudoputamen (C-Pu), which represents divergence among species spanning approximately 94 million years of evolution. We observed a lower neuron-to-glia ratio in primate striata compared to non-primates, reflecting the allometric scaling of neuron density and relative glia density invariance in larger brains. Among neurons, eccentric spiny projection neurons (eSPNs) - an SPN of unknown function - showed significantly lower proportions in non-primate striata for both CN and Pu. Focusing on the heterogeneity within interneurons, we identified two bat striatal interneuron cell types that are nearly absent in other species: which express LMO3, and co-express FOXP2 and TSHZ2. Other striatal interneurons also exhibited differential abundance between primates and non-primates. In summary, we provide a comprehensive snRNA-seq dataset of dorsal striatum, identify two distinct, previously uncharacterized populations of bat interneurons, and uncover fundamental cellular composition differences between primate and non-primate striata. - Source: PubMed
Publication date: 2026/05/25
Buyukkahraman GozdeCaglayan EmreHörpel Stephen GZhang Yaqiangvan Tussenbroek Ine AOrozco Carlos GOh EmilyHopkins William DSherwood Chet CRoberts Todd FVernes Sonja CKonopka Genevieve - Vocal communication is fundamental for social interaction across species, yet the neural mechanisms that shape vocal circuit development remain poorly understood despite their relevance to neurodevelopmental disorders. Here, we investigate vocal circuit development in mice using isolation-induced ultrasonic vocalizations (USVs) in neonates. An activity-tagging approach identifies the ventromedial prefrontal cortex (vmPFC) as a cortical region strongly activated during USV emission. We find a predictable temporal correlation between vmPFC activity and USV emission using in vivo fiber photometry. Selective activation and inhibition of vmPFC neurons establishes a causal role of vmPFC in vocalization. Interestingly, chronic activation of vmPFC neurons not only increases Foxp2, a gene implicated in childhood speech apraxia, but also Vglut1-labeled synapses in the striatum, suggesting that activity-dependent increases in Foxp2 may promote corticostriatal synaptogenesis. Consistent with this finding, neonatal vmPFC activation partially rescues USV deficits in Foxp2 heterozygous mutant mice. Collectively, our results identify the vmPFC-striatal circuit as a key regulator of neonatal vocalization and suggest that Foxp2 may mediate activity-dependent development of vocal circuits. - Source: PubMed
Publication date: 2026/05/19
Chen Shih-YunPang Hao-YuFan Pao-WenWu Guan-YingLin Wan-TingLiu Fu-ChinKuo Hsiao-Ying - Humans possess human-specific traits such as spoken language and lineage-specific traits such as ape-specific taillessness . Previous efforts to identify the DNA sequences responsible for such human traits were limited by necessary accommodations for poor genome assembly quality and lack of population genomic sampling . Here, we implement new algorithms that combine the near-complete human reference pangenome alignment with a new near-complete simian cross-species alignment to define human- and lineage-specific DNA sequences fixed across human haplotypes. Previously reported amino acid substitutions linked to human spoken language and transposable element insertion contributing to ape taillessness were unique to their respective clades and fixed in sampled humans. In contrast, widely used sets of candidate human-mutated loci showed limited enrichment for either human specificity or fixation. Integration with candidate -regulatory elements identified putative regulatory sequences specific to humans and linked to human-specific traits like hair reduction and brain transcriptome patterning . Although brain-associated fixed regulatory changes were present in all lineages, enrichment for spoken language was human-specific and enrichment for receptive language was ape-specific. This study provides a new pangenome-aware comparative framework and catalogs of candidate genomic loci to trace the evolutionary origins of common human traits and disease risks. - Source: PubMed
Publication date: 2026/05/04
Goh Chern-SingDavenport Matthew HLee ChulJarvis Erich D