ZIC1, affinity purified anitbody, goat, 100 ug.
- Known as:
- ZIC1, antigenic enriched anitbody, caprine, 100 ug.
- Catalog number:
- GT15242-100
- Category:
- -
- Supplier:
- Neuromi
- Gene target:
- ZIC1 affinity purified anitbody goat 100 .
Related genes to: ZIC1, affinity purified anitbody, goat, 100 ug.
- Gene:
- ZIC1 NIH gene
- Name:
- Zic family member 1
- Previous symbol:
- -
- Synonyms:
- ZIC, ZNF201
- Chromosome:
- 3q24
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-09
- Date modifiied:
- 2013-01-08
Related products to: ZIC1, affinity purified anitbody, goat, 100 ug.
Related articles to: ZIC1, affinity purified anitbody, goat, 100 ug.
- Animal body color patterns are highly diverse and play critical roles in camouflage, intraspecific communication, and environmental adaptation. Holothuria edulis, an important echinoderm inhabiting tropical waters, exhibits a typical dorsoventral dichromatism. This unique body color difference represents a key phenotypic trait for its habitat adaptation; however, the core differential genes regulating this trait remain to be elucidated. In this study, comparative transcriptome sequencing was performed on the dorsal and ventral body wall tissues of H. edulis, leading to the identification of a number of differentially expressed genes (DEGs), followed by GO functional annotation and KEGG pathway enrichment analysis. GO enrichment analysis indicated that the DEGs were significantly enriched in functional categories such as extracellular region, peptidase inhibitor activity, and tetrapyrrole binding. KEGG pathway analysis further revealed significant enrichment of protein digestion and absorption, the TNF signaling pathway, and cholesterol metabolism. Notably, the pigmentation-related gene FMO2 was highly expressed in the dorsal body wall tissue, whereas cyp1a1, ZIC1, Slc7a11, WNT-1, and ADAMTS20 were highly expressed in the ventral body wall tissue. This study identified DEGs and enriched pathways associated with dorsoventral body color differences in H. edulis, providing new insights into the molecular regulatory mechanisms underlying body color pattern formation. From the perspective of aquaculture applications, body color is one of the important traits affecting the quality and market value of sea cucumber products. Elucidating the molecular mechanisms of body color variation can provide a scientific basis for molecular marker-assisted breeding of superior sea cucumber variety. - Source: PubMed
Publication date: 2026/08/14
Yan JunqiLiu ShilinZhang LibinSu FangWu QianwenTolon Mustafa TolgaGökçek Emel ÖzcanXing Lili - Down feathers and contour feathers are two distinct feather types with vastly different structures and functions coexisting in the same individual. However, the molecular mechanism underlying these differences remains unclear. In this study, skin tissue containing intact feather follicles was collected from four anatomically defined regions of healthy Beijing ducks () for transcriptomic sequencing: the breast and abdomen, which generate down feathers, and the wingtips and rump, which produce contour feathers. To mitigate bias arising from site-specific effects, we established paired comparisons between contour feathers and down feathers across different regions. Across all comparisons, 36 core differentially expressed genes (DEGs) were consistently identified. These encompassed nine family transcription factors across three paralogous clusters, family members ( and ), , , , cytoskeletal and sarcomeric genes (, , , ), extracellular matrix regulators (, , ), and lipid metabolism-related genes (, ), among others. Pathway enrichment analysis revealed that transcriptomic variations in different feather follicles involve gene modules functioning in positional identity, cytoskeletal organization, extracellular matrix remodeling and lipid metabolism, with potential neuroendocrine modulation. The transcriptomic dataset established here facilitates future studies on the molecular mechanisms of feather differentiation and offers a reference for molecular breeding to enhance down feather yield and quality of Beijing ducks. - Source: PubMed
Publication date: 2026/07/22
Wang WenguiGuo JiangpengWang LiangZhang MengZhang XinyeJiang XiaoyuChen TairanMei XiaohanRen XufangQu Lujiang - Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal cancer linked to high-risk human papillomavirus (HPV) infection in approximately 90% of cases. Current circulating tumor DNA (ctDNA) approaches in ASCC primarily rely on pathogenic HPV-based biomarkers; however, these methods do not detect all HPV strains and are not applicable to HPV-negative tumors. To address this limitation, we developed a ddPCR assay targeting hypermethylated genomic CpG biomarkers, allowing ctDNA detection independent of tumor HPV status. - Source: PubMed
Publication date: 2026/07/02
Kahns SørenCanto Luisa M DStokkebro Laura EMadsen Jonna SSteenbergen Renske D MLindebjerg JanVarnum ClausHavelund Birgitte MJensen Lars HHansen Torben FJakobsen Anders K MSpindler Karen-Lise GAndersen Rikke F - Dandy-Walker malformation (DWM) is a condition characterized by a cyst in the posterior cranial fossa contiguous with the fourth ventricle, combined with complete or partial agenesis of the cerebellar vermis; and elevation of the cerebellar tentorium, torcular Herophili, and transverse sinuses. DWM has been linked to specific genetic variants, with pathogenic or likely pathogenic variants reported in FOXC1, ZIC1, and ZIC4. Variants in the TUBB2B and TUBB3 genes are associated with abnormalities in tubulin, leading to cerebellar hypoplasia. In our study, three patients diagnosed with DWM underwent whole-genome analysis using next-generation sequencing, and two were found to have heterozygous variants in the tubulinopathy-associated genes TUBB2B and TUBB3, respectively. These findings indicate that some cases previously diagnosed as DWM may fall under the spectrum of tubulinopathies associated with cerebellar hypoplasia. - Source: PubMed
Publication date: 2026/06/17
Ueno KatsuyaHigasa KoichiroHayashi MikioIsozaki HarunaMiyata MayukoNaito NobuakiLi YiTakeda JunichiNonaka Masahiro - BACKGROUND: The ZIC gene family (ZIC1–ZIC5) encodes zinc-finger transcription factors with established roles in neural development. However, a systematic pan-cancer analysis integrating their multi-omics landscapes, clinical prognostic value, and immunomodulatory mechanisms remains unexplored, limiting their potential as cross-cancer biomarkers. METHODS: We performed a comprehensive multi-omics analysis across 33 cancer types, assessing ZIC1-ZIC5 gene expression, prognostic significance, genomic alterations (somatic mutations, copy number variations), and immune interactions (immune infiltration, checkpoint genes, microsatellite instability, and tumor mutation burden). Drug sensitivity analysis (validated by CCK-8 assays) and immunotherapy cohort validation were conducted, with focused immune infiltration assessment in liver hepatocellular carcinoma (LIHC). Additionally, using qRT-PCR and Western blot, we assessed the expression of ZIC2 in tissues from hepatocellular carcinoma patients and investigated the transcriptional networks of ZIC genes across various cell populations within the tumor microenvironment. RESULTS: ZIC genes exhibited cancer-type-specific dysregulation, significantly correlating with patient survival, genomic instability, and immune cell infiltration. Drug response analysis identified ZIC expression as a potential predictive biomarker, further corroborated by CCK-8 results confirming the therapeutic vulnerability of ZIC2-high HCC cells to alisertib. Notably, distinct ZIC signatures were linked to immunotherapy outcomes, as supported by GSEA-enriched immune pathways. In LIHC, ZIC alterations were closely associated with immune microenvironment dynamics, corroborated by protein-level validation. CONCLUSION: This study identified ZIC family genes as multi-functional regulators in pan-cancer contexts, serving as promising prognostic biomarkers and therapeutic targets across cancers, particularly in LIHC. Their immune-modulatory functions highlight their potential utility in immunotherapy optimization, providing a foundation for future translational research in precision oncology. - Source: PubMed
Publication date: 2026/04/28
Ma PengyiZhang FeijuanMa Pengchai