ATP1a1 ELISA kit
- Known as:
- ATP1a1 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ATP1a1-Ra
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ATP1a1 ELISA kit
Related genes to: ATP1a1 ELISA kit
- Gene:
- ATP1A1 NIH gene
- Name:
- ATPase Na+/K+ transporting subunit alpha 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2016-10-05
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- The rising prevalence of metabolic-associated fatty liver disease (MAFLD) poses a serious public health threat, while long non-coding RNAs, key regulators of hepatic lipid metabolism, are closely linked to its development and progression. This study identified a novel MAFLD-associated antisense lncRNA, , aiming to characterize its molecular structure and elucidate its regulatory role in hepatic lipid metabolism. - Source: PubMed
Publication date: 2026/05/12
Yu LinLiu SiqiXiao YangWang JialeYang XingzhenCheng QiuchenLi QiuhuaYin DanLiang YuehuiLiang XueHou MenglongYu JingsuLi YixingZhou LeiLiang Yunxiao - In vitro production (IVP) of bovine embryos often results in lower developmental competence compared to in vivo-derived embryos. This disparity is further exacerbated by oocyte cryopreservation (vitrification). This study aimed to investigate the molecular basis of reduced embryo quality by profiling the transcriptomic impact of in vitro maturation (IVM) and vitrification on bovine blastocysts.Day 7 blastocysts from three groups were analyzed: (1) in vivo: control embryos produced entirely in vivo, (2) IVF: embryos from fresh oocytes subjected to IVM and in vitro fertilization, and (3) V_IVF: embryos from vitrified-thawed oocytes subjected to IVM and fertilization. Whole-blastocyst transcriptome profiling was performed using single-embryo RNA sequencing (SUPeR-seq; n = 3 blastocysts per group) and analyzed without cellular dissociation. Developmental competence was significantly reduced in the V_IVF group (~ 11.8% blastocyst rate) compared to the IVF group (~ 41.5%) and in vivo controls. Transcriptome analysis revealed 362 differentially expressed mRNAs in V_IVF embryos and 78 in IVF embryos compared to in vivo controls. Genes such as ATP1A1, GOT1L1, and QSOX1 were significantly altered, influencing pathways related to oxidative phosphorylation, lysosome activity, and chromatin organization. In addition, 694 DE-lncRNAs in the V_IVF group and 187 in the IVF group were identified. Exonic circRNAs (608) were detected with differential expression and enrichment in signaling and epigenetic pathways, including Hedgehog signaling and stem cell pluripotency regulation. Integrated network analysis revealed coordinated dysregulation across mRNA, lncRNA, and circRNA layers, suggesting disruption of multi-layered regulatory circuits. Overall, this study presents a detailed transcriptomic landscape of bovine blastocysts affected by IVM and vitrification. - Source: PubMed
Kolachi Hubdar AliZhang Pei-PeiAyantoye Jesse OluwaseunShahzad MuhammadYang BaigaoDong JianhuaLiu YangFeng XiaoyiPanhwar Muhammad IbrahimWan PengchengZhao Xueming - Atherosclerosis preferentially develops at arterial regions exposed to low shear stress (LSS), highlighting the critical role of local hemodynamic forces in disease initiation and progression. Emerging evidence indicates that endothelial lipid metabolism is a key determinant of vascular homeostasis; however, whether LSS directly regulates endothelial lipid droplets' (LDs) dynamics remains unclear. In particular, the mechano-transduction pathways linking shear stress to lysosome-mediated lipid processing within the endothelium have yet to be defined. - Source: PubMed
Publication date: 2026/05/15
Shi YiTan Ya-NanWu Li-DaWang Li-GuoGu YueZhou Wen-YingShao Meng-QianZhang Jun-Xia - Diabetic foot ulcers (DFUs) are among the most severe and debilitating diabetic complications, often leading to extremely high morbidity and mortality. Recently, increasing evidence has highlighted the role of necroptosis, a distinct type of programmed cell death distinct from apoptosis, in the progression and severity of DFUs. Understanding necroptosis-associated genes in DFUs could open new therapeutic avenues aimed at modulating this form of cell death, potentially improving outcomes for patients suffering from this serious diabetic complication. - Source: PubMed
Publication date: 2025/04/20
Yuan MeijieSun JianZhao ZhuoHu XiaomingFan WeijingShi HongshuoLiu Guobin - Due to the global obesity crisis, increasing numbers of women enter pregnancy with overweight or obesity. Their offspring are at greater risk of respiratory complications at birth due to metabolic changes that impact lung development that may reduce capacity for surfactant production. We hypothesize that a high-fat-high-energy diet (HF-HED) negatively impacts late gestation fetal lung development. - Source: PubMed
Publication date: 2026/04/27
Lock Mitchell CHuber Hillary FLi CunOrgeig SandraNathanielsz Peter WMorrison Janna L