CACNa1H ELISA kit
- Known as:
- CACNa1H Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CACNa1H-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CACNa1H ELISA kit
Ask about this productRelated genes to: CACNa1H ELISA kit
- Gene:
- CACNA1H NIH gene
- Name:
- calcium voltage-gated channel subunit alpha1 H
- Previous symbol:
- -
- Synonyms:
- Cav3.2
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-08
- Date modifiied:
- 2016-02-04
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Publication date: 2026/08/25
Sorkhou MaryamKim Helena KFarzan FaranakFoster Jane AFrey Benicio NHusain Muhammad IKennedy Sidney HLam Raymond WMilev RoumenMulsant Benoit HMüller Daniel JQuilty Lena CSoares Claudio NTaylor Valerie HTurecki GustavoKloiber Stefan - The germline genetic basis of bilateral primary aldosteronism (PA) remains poorly understood, particularly in apparently sporadic disease. We investigated rare germline variants in canonical and candidate genes in patients with bilateral PA associated with resistant hypertension and/or hypertension diagnosed before 40 years of age. - Source: PubMed
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Santana Lucas SAlves-Fernandes Débora KLima Sobrinho Jose Antonio BFreitas-Castro FelipeRossetti Lucas BOkubo JessicaFagundes Gustavo F CKawahara Eduardo ZMendes Thiago SBortolotto Luiz APio-Abreu AndreaSilva Giovanio VDrager Luciano FLatronico Ana ClaudiaAlmeida Madson Q - Three-dimensional genome organization stabilizes cell-type-specific gene expression, yet the tissue-restricted factors that maintain chromatin insulation remain poorly understood. Here, we identify the muscle-specific ribosomal protein Rpl3l as an unexpected nuclear regulator of genome architecture in atrial cardiomyocytes. Rpl3l is enriched in the nucleus and nucleolus, where it binds its own genomic locus and stabilizes a CTCF-anchored chromatin boundary that represses the T-type calcium channel gene . Loss of weakens local chromatin insulation, increases long-range contacts across the - locus, derepresses , and increases susceptibility to atrial fibrillation (AF), which is suppressed by pharmacological inhibition of T-type calcium channels. Furthermore, AF-associated RPL3L variants exhibit impaired nucleolar localization, reduced rRNA binding, and defective repression of in human iPSC-derived atrial cardiomyocytes. Together, these findings reveal a ribosomal protein-chromatin axis linking genome insulation to ion-channel dosage control and cardiac rhythm stability, expanding the repertoire of cell-type-specific genome architecture regulators. - Source: PubMed
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Nakamura MakotoChen XiaoxinYao ShunChan Lynette XinHongmei RuanBoulinguiez AlexisLally NavWu HaoKodani KaraHirose KentaroPirruccello JamesMalerba AlbertoCheng YifanVedantham VasanthTan LongzhiOlgin Jeffrey ELang DiHuang Guo N - Depression has been increasingly associated with cancer progression and patient outcomes, yet its molecular and immunological correlates within tumors remain incompletely understood. This study aimed to investigate depression-associated gene signature across cancers and evaluate their relationship with tumor biology, immune microenvironment, and clinical outcomes, with a focus on breast cancer. - Source: PubMed
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Chen GuanlingYin BaoliangKhan MuhammadYang YipengSun QianZhang TingfengHu HongLin Jie - Disruption of cation homeostasis is increasingly recognized as a driver of breast cancer (BC) progression, yet a clinically actionable gene signature that quantifies this disturbance has been lacking. This study aims to systematically explore the value of cation homeostasis-related genes in the prognosis assessment of BC through bioinformatics analysis, construct and validate a prognostic model based on these genes, and integrate immune mechanism and drug sensitivity analyses to provide novel biomarkers and potential therapeutic targets for precise prognosis evaluation and individualized treatment of BC. - Source: PubMed
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