CACNa1B ELISA kit
- Known as:
- CACNa1B Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CACNa1B-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CACNa1B ELISA kit
Related genes to: CACNa1B ELISA kit
- Gene:
- CACNA1B NIH gene
- Name:
- calcium voltage-gated channel subunit alpha1 B
- Previous symbol:
- CACNL1A5
- Synonyms:
- Cav2.2, CACNN
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-06-01
- Date modifiied:
- 2016-10-05
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- Lung cancer recurrence and therapeutic resistance are driven by cancer stem cells (CSCs), yet clinically available CSC-targeted therapies remain lacking. To identify actionable anti-CSC agents, we screened 1018 FDA-approved drugs using a 3D sphere culture system enriching lung CSC-like cells. Trimebutine, a gastrointestinal motility regulator targeting G-protein-coupled receptors (GPCRs), was identified as a potent agent with over 49.5-fold higher selectivity toward lung CSC-like cells (SI > 49.55) compared with standard therapies such as cisplatin (SI = 1.39) and gefitinib (SI = 1.00). In H460-SP spheres, trimebutine markedly impaired sphere-forming capacity, reduced cell viability, and downregulated key CSC surface markers (CD133, CD44) alongside stemness regulators (c-MYC, EpCAM, BMI1, OCT3/4, NANOG, SOX2, SMAD3). Mechanistically, trimebutine suppressed overexpressed calcium and potassium channels (, , , , ), attenuating downstream YAP/TAZ-TEAD signaling within the Hippo pathway to trigger apoptosis. In combination with cisplatin, trimebutine exhibited strong synergistic efficacy (Chou-Talalay combination index, CI = 0.015-0.228) in H460-SP spheres and patient-derived lung tumor organoids, suppressing cell viability, stemness marker suppression, and apoptotic cleavage of caspase-3 and PARP compared to monotherapies. Overall, trimebutine targets lung CSC populations by disrupting GPCR-ion channel-Hippo signaling crosstalk, providing a strong preclinical rationale for trimebutine-cisplatin combination strategies to overcome drug resistance and recurrence in lung cancer. - Source: PubMed
Publication date: 2026/09/15
Seo JiHyeLee HeejinChoi Dong KyuKim Young-KyuWoo SominLee ChangkyuChoi Jeong InJiang GeOh Bae JunLee Dong-SeokMin Sang-Hyun - Mild cognitive impairment (MCI) is a clinically heterogeneous condition characterized by substantial variation in structural abnormalities and cognitive impairment. However, existing neuroimaging-based approaches are limited by insufficient modeling of coordinated gray-white matter alterations and vulnerability to site effects in multi-center data. Here, we propose a Macro-Micro Structural Integration (MMSI) framework for characterizing structural-deviation heterogeneity and identifying imaging-derived MCI subgroups. The framework integrates gray-matter morphological features derived from structural magnetic resonance imaging and white-matter microstructural features derived from diffusion MRI. A Dual-Condition Variational Autoencoder was developed to separate biological variation from site-related effects and learn a site-robust normative representation using cognitively normal participants. Tract-specific MMSI scores were subsequently derived to quantify each participant's structural deviation from the normative reference. In a multi-center clinical cohort (N = 860), Gaussian mixture modeling of the tract-wise MMSI profiles identified lower- and higher-deviation MCI subgroups that exhibited significant differences in global cognition, delayed memory, and word recognition. Comparisons with conventional imaging biomarkers, machine-learning classifiers, and statistical harmonization methods further supported the value of the proposed framework. Evaluation in the Alzheimer's Disease Neuroimaging Initiative cohort demonstrated a concordance accuracy of 0.769 between the imaging-derived groups and the clinically predefined early- and late-MCI categories, exceeding the gray matter-only and white matter-only models by 7.7 and 12.3 percentage points, respectively. Transcriptomic association analysis identified KRT77 and CACNA1B as significantly associated with tract-specific MMSI scores after false discovery rate correction. Functional enrichment of the PLS-derived MMSI-associated gene set implicated biological processes related to neural signal transduction, learning and memory, calcium signaling, and immune responses. Together, these findings indicate that the MMSI framework provides a site-robust and interpretable approach for characterizing cross-sectional structural-deviation heterogeneity in MCI and offers preliminary biological support for the identified imaging patterns. - Source: PubMed
Publication date: 2026/09/16
Zhang QichenZhang DiZhou RuixiZhao KunWang DaweiYao HongxiangZhou BoLu JieZhang XiHan YingWang PanLiu YongZong Fangrong - Topmouth culter () is one of the most economically important freshwater fish in China, but intensive aquaculture has caused germplasm degradation and reduced growth performance, while the genetic basis underlying growth variation in this species remains poorly understood. This study aimed to identify major-effect loci and candidate genes associated with growth-related traits to support molecular breeding. Whole-genome resequencing (average depth 11.44×) was performed on 300 individuals derived from random mating among three geographic populations (Danjiangkou, Taihu, and Poyang Lake); 239 individuals with complete phenotypic records were retained for a genome-wide association study (GWAS) of five growth-related traits, including body weight (BW), body weight without viscera (BWW), total length (TL), body length (BL), and body height (BH). After stringent filtering, 7,597,008 high-quality single-nucleotide polymorphisms (SNPs) were obtained, and association analysis was conducted using a linear mixed model, followed by Benjamini-Hochberg false discovery rate correction and 1000-permutation testing for BW and BL. Six genome-wide significant SNPs and 473 suggestive SNPs were identified, with individual significant SNPs explaining over 11% of phenotypic variance, indicating candidate loci of putatively moderate-to-large effect. Significant SNPs were predominantly clustered on chromosomes 16 and 19. Four candidate genes-, , , and -were identified, with functions related to lipid metabolism, muscle structure, and cell proliferation. This first population-level GWAS in topmouth culter provides valuable molecular markers for marker-assisted selection and lays a foundation for accelerated genetic improvement of this species. - Source: PubMed
Publication date: 2026/06/25
Jiang WenpingLuo JunzhiZheng JianboLiu ShiliChi MeiliCheng ShunZhu ChaoHang XiaoyingPeng MiaoLi Fei - N-type voltage-gated calcium channels (Ca2.2) are validated targets for chronic pain management. Although ziconotide is clinically effective, its use is hampered by a narrow therapeutic window and severe side effects. This review examines the subunit structure of Ca2.2 and its fundamental role in nociceptive signaling. We focus on emerging therapeutic strategies developed in recent years, including the optimization of direct blockade, the inhibition of channel trafficking, the modulation of signaling pathways, and targeted channel depletion. These advancements provide a deeper understanding of calcium channel regulation and identify promising targets for safer, more effective, and precision-based pain management. - Source: PubMed
Publication date: 2026/06/26
Luo FanglaSu JunweiKe XinlongChen YeruChen Gang - Autism spectrum disorder (ASD) may be a predisposing factor in the development of catatonia, which has been demonstrated to be effectively treated using electroconvulsive therapy (ECT). CACNA1 channelopathy mutations have been associated with autism spectrum disorder, intellectual disability, and epilepsy. The single published case report of ECT use in CACNA1 subunit mutations demonstrated a negative outcome, and no current case reports on CACNA1B, CACNA1C, CACNA1D, or CACNA1E mutations have been published. We present a case of an adolescent with a known CACNA1D mutation and symptoms of excited catatonia who experienced a reduction in the frequency and severity of self-injurious and violent behavior following treatment with ECT. Our case demonstrates the use of ECT for catatonia in an individual with a CACNA1 mutation without complication and with a positive therapeutic response. - Source: PubMed
Publication date: 2026/05/26
Mancine RyleyKuang JoannaRaghunandan ChristinaPalffy Alexander