BHLHB8 ELISA kit
- Known as:
- BHLHB8 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-BHLHB8-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- BHLHB8 ELISA kit
Related genes to: BHLHB8 ELISA kit
- Gene:
- BHLHA15 NIH gene
- Name:
- basic helix-loop-helix family member a15
- Previous symbol:
- BHLHB8
- Synonyms:
- MIST1, bHLHa15
- Chromosome:
- 7q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-04
- Date modifiied:
- 2015-11-18
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- - Source: PubMed
Publication date: 2026/06/05
Dai JiJi HaoqiangBai HuihuiZhong QilongSun HaohangChen MengzeChen QiYan MeidiZhang DandanZhang Shuangshuang - Breast cancer exhibits marked clinical heterogeneity and dynamic epigenetic reprogramming during tumor progression, yet current subtyping approaches fail to capture molecular changes associated with metastasis. Here, we establish a comprehensive biobank of patient-derived organoids (PDOs) from matched primary tumors, adjacent normal tissues, and lymph node metastases. Integrated genomic, transcriptomic, and epigenetic analyses demonstrate that these PDOs preserve tumor-specific molecular signatures and recapitulate epigenetic remodeling during disease evolution. Epigenetic profiling defines four distinct clusters, characterized by unique transcription factor (TF) networks, pathway activities, and therapeutic vulnerabilities not fully represented by conventional classifications. The lymph node metastasis cluster, predominantly comprising metastatic PDOs, displays extensive chromatin remodeling driven by metastasis-enriched TFs, whose depletion markedly impairs spontaneous metastasis in vivo. Together, these findings establish PDO-based epigenetic characterization as a platform for elucidating regulatory mechanisms underlying breast cancer progression and for advancing precision therapeutic strategies. - Source: PubMed
Publication date: 2026/03/16
Rao XinxinWang JingwenQiao ZhibinHong LeiQiao MengxueNi LiangweiSong AixiaDeng YunZhao XuMeng JinChen XingxingZhou YifanXue JingyanChi YayunWang XinruiYu ZhaoweiChen QianqianXu ConglingTang ShuangHu JingXu MidieXu WeiZhang ZhenZhang YongXu YanhuiJiang Yi-ZhouWu JiongShen MinhongGuo XiaomaoYu XiaoliChen Fei Xavier - Ionocytes are distinct epithelial sensory cells scattered throughout the ductal system of the salivary glands. These cells are distinguished by their unusual morphology, as well as by a specific transcriptomic signature that includes the expression of the forkhead boxI1 (Foxi1) and achaete scute-like 3 (Ascl3) transcription factors. Currently little is known about the biology or function of ionocytes in the salivary glands. To facilitate the characterization of these cells, we produced an inducible Cre mouse allele driven by the Ascl3 promoter. This strain was crossed with a reporter to fluorescently label Ascl3 ionocytes, highlighting that they are the site of enriched cystic fibrosis transmembrane conductance regulator (Cftr) expression in the salivary glands and demonstrating the proximity of these cells to neurons. Conditional Cre-mediated cell ablation, using diphtheria toxin (DTA), removed Ascl3 ionocytes from the salivary glands and resulted in an altered pH of total saliva, supporting a function for ionocytes in transepithelial ion flow. Finally Cre-mediated expression of the calcium indicator GCaMP6f revealed thatAscl3 ionocytes exhibit unique properties not observed in the acinar or surrounding duct cells, including elevated basal [Ca], spontaneous blinking in the absence of stimulation and a rapid loss of [Ca] after nerve stimulation. These unique properties distinguish ionocytes as a specialized subset of salivary gland duct cells. KEY POINTS: Ionocytes are epithelial cells originally identified in marine teleosts and subsequently reported to be present in pulmonary epithelia, olfactory epithelium and salivary and lachrimal glands. We produced an inducible Cre mouse allele driven by the Ascl3 promoter to study the distribution and function of Ascl3 ionocytes in salivary glands. By crossing this strain with a fluorescent reporter, we demonstrated the prominent localization of Ascl3 ionocytes in salivary gland ducts. Cre-mediated expression of the genetically encoded Ca indicator GCamp6f in Ascl3 ionocytes revealed unique Ca signalling properties of this cell type distinct from acinar cells and other ductal cell types. Cre-mediated ablation of Ascl3 ionocytes altered the pH of the final saliva. We conclude that ionocytes resident in salivary gland ducts function to modify the primary saliva contributing to the composition of the final saliva entering the oral cavity. - Source: PubMed
Publication date: 2026/02/20
Uchida HitoshiMaruyama Eri OTakano TakahiroAure Marit HGlasner Melissa FSoares Zamira GuerraFaustoferri Roberta CThomas V KayeMakarenkova Helen PYule David IOvitt Catherine E - Although the liver exhibits remarkable regenerative capacity, expanding hepatocytes in large quantities in vitro without compromising their function remains challenging, presumably due to the absence of key environmental signals. Identifying factors that enable long-term in vitro expansion of hepatocytes is essential for advancing liver research. - Source: PubMed
Publication date: 2026/02/03
Li BingGuo RenWang ShitongZhang JingweiWang ShunYuan QiantingZheng HuixiangWang YaxuanSun BinTang ErjiangXie Xin - Radiotherapy serves as an essential therapeutic modality for head and neck malignancies. However, many patients who undergo head and neck radiation (HNR) frequently experience different severities of xerostomia. Berberine (BBR) has a variety of pharmacological functions and has shown favorable clinical efficacy. However, its therapeutic potential and mechanistic basis in xerostomia have not been explored. - Source: PubMed
Publication date: 2026/01/12
Lian QihangTian YueWang NanLuo YikunWang XiLiu BanghuiTian HefeiLiu XiangjunYin QingpingXu ZhenniHuang YujunHuang LingxiaoLei XudanLang JinyiFeng MeiLiu Dengqun