CCKAR ELISA kit
- Known as:
- CCKAR Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CCKAR-b
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CCKAR ELISA kit
Related genes to: CCKAR ELISA kit
- Gene:
- CCKAR NIH gene
- Name:
- cholecystokinin A receptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-13
- Date modifiied:
- 2015-08-24
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- Feeding behavior is a key factor influencing growth performance and feed efficiency in poultry, yet its complex phenotypes remain difficult to quantify accurately, limiting the application of large-scale behavioral data in genetic and molecular analyses. In this study, feeding behavior and feed efficiency-related phenotypes were recorded in 829 Tianfu Nonghua ducks using an automated feeding monitoring system integrated with radio frequency identification (RFID) technology. Genetic parameter estimation indicated that the heritability of feeding behavior traits ranged from 0.25 to 0.39. Individuals were classified into high-frequency feeding (HFF) and low-frequency feeding (LFF) groups. Phenotypic analysis showed that ducks in the HFF group had significantly higher residual feed intake (RFI) and feed conversion ratio (FCR) than those in the LFF group. Based on this grouping, transcriptome sequencing was performed on the hypothalamus, pituitary, and liver tissues. A total of 266, 181, and 94 differentially expressed genes (DEGs) were identified in the three tissues, respectively. Enrichment analysis highlighted tissue-specific pathways, including neuroactive ligand-receptor interaction and calcium signaling in the hypothalamus, the Apelin signaling pathway in the pituitary, and steroid hormone biosynthesis in the liver. Appetite-related genes in the hypothalamus (PMCH, HCRT, and CCKAR) and endocrine and metabolic genes in the pituitary and liver (TRH and NEGR1) showed differential expression between feeding strategies. Weighted gene co-expression network analysis further identified hub genes (ITPKB, BAMBI, and BCKDHB) associated with total feeding bouts (TFB). These findings provide new insights into the genetic architecture of feeding behavior traits and the molecular differences associated with divergent feeding patterns in ducks. - Source: PubMed
Publication date: 2026/04/28
Guo ShihaoLiu XingXi YangQi JingjingYang ZhaoHan XuLing WeikangBai LiliHuang AnqiHu JiweiLi LiangLiu Hehe - Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD), are progressive disorders with limited therapeutic options. Centella asiatica (C. asiatica), a medicinal and edible plant, has been reported to exert neuroprotective and anti-neuroinflammatory properties. Yet, the mechanisms underlying its effects against neurodegenerative diseases remain largely unclear. - Source: PubMed
Publication date: 2026/07/31
Xie YuxiLim Chong-TeikLam Xin-JiehCheah Pike-SeeLing King-HwaHuang Tan - Sensory neurons innervating the heart transmit chemical and mechanical cues to the central nervous system via the dorsal root ganglion (DRG) and nodose ganglion (NG). Despite their importance in cardiac pain and cardiovascular reflexes, the molecular and functional properties of heart-specific sensory (HS) neurons remain elusive. Here, DRG and NG neurons innervating the heart were FACS purified using a retrograde labeling strategy with Di-8-ANEPPQ, then characterized molecularly by bulk RNA sequencing or evaluated functionally in cocultures with neonatal cardiomyocytes. DRG and NG neurons formed functional connections with neonatal cardiomyocytes as demonstrated by immunolabeling, electron microscopy, and optogenetic manipulation. Functionally coupled DRG neurons exhibited enhanced spontaneous and evoked Ca activity in response to optogenetic and chemical stimulation, indicating dynamic neuro-cardiac communication. Global RNA sequencing analysis revealed that DRG and NG neurons exhibited distinct transcriptomic profiles, including enrichment of transcripts encoding ion channels and G protein-coupled receptors, compared with their respective total populations. In DRG tissue, these included Scn10a, P2xr2, and Mrgprd, whereas NG neurons preferentially expressed P2xr2, Ptgdr, and Cckar, collectively supporting a combination of molecular signatures including nociceptors. Collectively, these findings define molecularly distinct sensory pathways connecting the heart and the sensory nervous system, providing mechanistic insights and highlighting potential targets for modulation of cardiovascular reflexes and hemostasis. - Source: PubMed
Akgul Caglar TKazci Y EDurdu Z BSahoglu Goktas SBay SVatandaslar ETurhan M UOzturk GCagavi E - : Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with limited therapeutic options, a high mortality rate, and poor overall survival, necessitating the development of new therapeutic and diagnostic strategies. This study investigated the potential of plasma-derived small extracellular vesicles (sEVs) as a source of molecular biomarkers associated with the treatment response. Plasma samples were obtained from patients with locally advanced and borderline resectable PDAC at baseline and following neoadjuvant chemotherapy, either FOLFIRINOX (5-FU [fluorouracil], leucovorin, oxaliplatin, and irinotecan) or GEM-ABRAX ( gemcitabine plus nab-paclitaxel), followed by stereotactic body radiation therapy (SBRT). sEVs were isolated from plasma at baseline, after neoadjuvant chemotherapy, and following SBRT, and were characterized by nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), nano-flow cytometry, and real-time PCR (RT-PCR). The isolated sEVs exhibited an average size of <200 nm, expressed canonical exosome markers (CD63 and CD9), and exhibited pancreatic cancer (PanC)-associated markers, including cholecystokinin A receptor (CCK-AR) and carbohydrate antigen 19-9 (CA19-9). The sEV cargo included several PanC-associated microRNAs (miRNAs). Notably, the expression profiles of these miRNAs demonstrated interpatient variability, though a subset of miRNAs showed statistically significant changes following treatment. These findings support the feasibility of sEV isolation and molecular profiling from patient plasma and warrant further investigation as a potential source of biomarkers in pancreatic cancer. - Source: PubMed
Publication date: 2026/05/23
Paluri Ravi KumarKumar AshishSu YixinSingh SangeetaGbolahan Olumide BManne AshishManne UpenderDeep Gagan - Apuschkin et al. (2024) proposed a GPCR-based transcriptomic atlas for midbrain dopamine (DA) neuron subpopulations, including candidates such as , , and . To guide genetic targeting, these markers must reflect functional expression in adult DA neurons. Using hybridization, Cre-dependent reporter lines, and both intracranial and systemic viral approaches, we find no evidence of adult -mediated recombination in DA neurons, while -driven recombination is consistent with developmental expression only. Notably, expression overlaps extensively with midbrain populations, indicating that it does not define a distinct DA neuron class. Furthermore, analysis of independent spatial transcriptomic datasets together with our MERFISH data shows that many proposed GPCR markers are not detectably expressed in adult DA neurons. These findings demonstrate that transcriptomic enrichment does not always yield reliable adult markers and highlight the need for functional validation prior to use in circuit targeting. - Source: PubMed
Publication date: 2026/05/14
Shah MoueezWu RenqiYe QiaoBugescu RalucaVilla Andrew PWong JustineGarcia FernandoTan ZhiqunXu XiangminLeinninger Gina MSteele Andrew D