ATRN ELISA kit
- Known as:
- ATRN Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ATRN-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ATRN ELISA kit
Related genes to: ATRN ELISA kit
- Gene:
- ATRN NIH gene
- Name:
- attractin
- Previous symbol:
- -
- Synonyms:
- DPPT-L, MGCA
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-30
- Date modifiied:
- 2015-08-26
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- Hepatolithiasis (HL) is a prevalent condition in hepatobiliary surgery, often complicated by hepatatrophia. This study aimed to identify gene mutations in HL specimens with hepatatrophia and construct a mutation landscape using whole-exome sequencing (WES). - Source: PubMed
Publication date: 2026/04/09
Tang DanGu XuanyuLiu DanYang JialiZhao Lijin - To explore systemic contributors to central serous chorioretinopathy (CSCR) pathogenesis, we performed untargeted serum proteomics in 60 male CSCR patients (30 acute, 30 chronic) and 60 age-matched controls using label-free LC-MS/MS with stringent statistical pairing. Among 242 abundant proteins identified, 27 (11.5%) were significantly different in CSCR, converging on pathways of complement activation, coagulation, oxidative stress, immune regulation, and response to external stimuli. Complement cascade components (C1QA, C1S, C3, C4B, C8A/B/G, CFB) were upregulated, while the regulators CFHR1 and CFHR2 were decreased, contrary to age-related macular degeneration. Oxidative stress-related proteins (haptoglobin, hemoglobin subunits, peroxiredoxin-2) were elevated, consistent with prior evidence of systemic redox imbalance in CSCR. Tetranectin (CLEC3B) decreased and attractin (ATRN) increased in CSCR were validated by ELISA. Multiplex immunofluorescence on the human retina localized tetranectin to Müller cells, including the outer limiting membrane, and to the RPE and attractin to photoreceptor segments, retinal pigment epithelium, Bruch's membrane, and the choriocapillaris, supporting potential roles of both proteins at the retina-choroid interface. A distinct systemic proteomic signature in patients with CSCR highlights complement dysregulation, oxidative stress, and stress responses to external stimuli and identifies tetranectin and attractin as candidate biomarkers, which should further be validated in other cohorts. - Source: PubMed
Publication date: 2026/02/05
Chambon ChristophePicard EmilieZola MartaAichedo SeikiLebon CécileYouale JennyMatet AlexandreBousquet ElodieFerreira ClaudeKowalczuk LauraThéron LaetitiaBehar-Cohen Francine - The differential diagnosis between Tuberculosis (TB) and Non-tuberculous Mycobacteria (NTM) has historically been constrained by the inadequate sensitivity and specificity of current diagnostic methods. Furthermore, distinguishing between Active Tuberculosis (ATB) and Latent Tuberculosis Infection (LTBI) poses significant challenges. This study aims to develop a molecular differentiation system for ATB, LTBI, and NTM by integrating plasma proteomics with multi-dimensional analytical techniques, while also exploring key biomarkers associated with disease progression and treatment response. - Source: PubMed
Publication date: 2025/12/22
Hu YanQuan ChaoZhou YuanyuanLiang ShangyanWang XuanLi JunLiu WenqiXu YuzhongLiu Peng - Although bacterial genomes encode numerous potential toxins, it is unclear how evolution drives the specificity of these important virulence factors. Using an insect CRISPR screen, we identified the transmembrane protein Attractin (ATRN) as the receptor for Nigritoxin (Ntx), a Vibrio toxin that causes seasonal shrimp pandemics. We found that Ntx's effector "warhead" inhibits translation via a previously uncharacterized mechanism. Moreover, we show that two related toxins require ATRN for entry but possess unrelated effector domains. One has a Rho-GTPase AMPylation function and the other an actin-targeting/proteolysis function. Our findings reveal the mechanism of Ntx entry and toxicity and show that the ATRN-targeting domain can deliver disparate effector domains, strongly indicating that this class of exotoxins can evolve as modular proteins using a common entry domain. - Source: PubMed
Publication date: 2025/10/11
Viswanatha RaghuvirLee DonghoonRobins William RMameli EnzoHu YanhuiKim Ah-RamHashmi YousufNishida HiroshiPrakash GyanButnaru MatthewChurchman SterlingMohr Stephanie EMekalanos John JPerrimon Norbert - The development of ultrasensitive proteomic methods for detecting potential protein tumor biomarkers remains a key challenge in modern biomedicine. We integrated data from classical reference proteomic methods─both panoramic (DDA-Shotgun LC-MS/MS) and targeted (MRM)─with a novel AFM-based enrichment approach coupled to mass spectrometry (AFM-MS), providing lower detection limits. This integrated strategy enabled the compilation of an expanded list of proteins associated with ovarian cancer progression. We identified a panel of previously unreported, ovarian cancer-specific candidate markers. A total of 371 proteins were found to be potentially involved in the pathological process, with 33% detected exclusively by the ultrasensitive AFM-MS method and 26% discovered through metabolomic associations. Notably, 6% of the identified proteins correspond to previously recognized ovarian cancer-specific markers, validating our multiplatform approach. Nine potential biomarkers are proposed for the first time, including ATRN, CPN1, APOF, TGM3, and CRNN. Immunoglobulin variable region peptides were reclassified as low-specificity background signals due to their high abundance and inflammation dependence. The identified biomarkers are present in blood at concentrations ranging from 10 to 10 mol/L. The proposed approach overcomes the sensitivity limitations of conventional proteomic methods and may be adapted for the discovery of candidate markers in other multifactorial diseases. - Source: PubMed
Publication date: 2025/11/17
Sarygina Elizaveta VGordeeva Arina IKozlova AnnaTarbeeva SvetlanaKliuchnikova Anna AMaterova Tatiana AIlgisonis Ekaterina VNovikova Svetlana EValueva Anastasia ARybakova Elizaveta EVavilov Nikita EFarafonova Tatiana EZgoda Victor GPleshakova TatyanaLisitsa AndreyArchakov Alexander IPonomarenko Elena