ASPN ELISA kit
- Known as:
- ASPN Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ASPN-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ASPN ELISA kit
Related genes to: ASPN ELISA kit
- Gene:
- ASPN NIH gene
- Name:
- asporin
- Previous symbol:
- -
- Synonyms:
- FLJ20129, SLRR1C, PLAP-1
- Chromosome:
- 9q22.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2017-07-14
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- Left bundle branch pacing (LBBP) has gained increasing attention as a novel pacing strategy, but its molecular underpinnings in the context of heart failure (HF) remain unclear due to limited LBBP-specific datasets.We integrated three GEO datasets (GSE5406, GSE19303, GSE21610) representing HF transcriptomics and performed batch correction, differential expression analysis, functional enrichment, immune infiltration profiling, weighted gene co-expression network analysis (WGCNA), hub gene identification, and drug-pathway prediction.PCA demonstrated successful batch correction across datasets. Differentially expressed genes (DEGs), including HOPX, NPPA, MYH6, SERPINA3, and ASPN, were identified. Enrichment analyses indicated extracellular matrix remodeling, cardiac development, and cGMP-PKG signaling. Immune analysis showed significant alterations in B cell memory, plasma cells, CD8 T cells, regulatory T cells, NK cells, monocytes, macrophages (M0/M1/M2), dendritic cells, and mast cells. WGCNA highlighted significant modules (MEpink, MElightyellow, MEyellow, MEgreenyellow) associated with treatment response. Hub gene analysis confirmed ASPN, HOPX, MYH6, SERPINA3, and NPPA as key drivers. Drug prediction suggested multiple candidates, including β-blockers, RAAS inhibitors, anti-fibrotic agents, vericiguat, metformin, and SGLT2 inhibitors.This integrative analysis of HF transcriptomics reveals potential immune remodeling, hub genes, and repurposable drugs relevant to LBBP response heterogeneity, providing hypothesis-generating insights and potential therapeutic strategies for validation in LBBP-specific cohort. - Source: PubMed
Publication date: 2026/05/11
Sun XiaTang XiangZhong WeiYuan WeiJin Mingfeng - Despite increasing representation of women in medicine overall, significant gender disparities persist in procedural specialties such as interventional pain medicine. Women remain underrepresented as speakers at national pain conferences and in leadership roles. Additionally, a pay gap between female and male pain physicians remains. This study aims to objectively demonstrate the above-mentioned inequities. - Source: PubMed
Catalanotto MarissaKim Serena JiyeonJaved Saba - Limited proteomic evidence makes it unclear to what extent alternative splicing (AS) isoforms are translated and functionally relevant in eukaryotes. Here, we present a comprehensive proteomic analysis in plants using large-scale data mining, extensive fractionation of AspN- and trypsin-digested proteomes, and both label-free and TMT labeling. In total, we identified 471 196 peptides from 22 479 proteins by searching against Araport11, revealing 32 110 isoform-specific peptides. Using an integrated proteogenomic workflow coupled with SUPPA, we classified these peptides into 2442 AS events, 879 of which involved intron retention (IR). Further analysis of unannotated events revealed 91 additional IRs that are translated, supporting that retained introns can give rise to peptides. AlphaFold modeling predicted the structural and functional impacts of these isoforms. Our dataset improved existing gene model annotations. By comparing wild-type plants with the AS mutant acinus pinin, we found that IR regulates transcript and protein abundance nonlinearly. Phenotypic assays revealed the functional consequences, including reduced chlorophyll, impaired growth, and increased anthocyanin. Overall, our results support widespread translation of AS isoforms in plants and suggest that AS contributes to proteome diversification, protein abundance regulation, and growth and developmental outcomes. - Source: PubMed
Reyes Andres VZhang ChristopherKarunadasa Sumudu SShrestha RubenGrismer TaraBryn SByun DanbiXu Shou-Ling - Lanthipeptides represent the largest group of ribosomally synthesized and post-translationally modified peptides (RiPPs). Lanthipeptides offer promising avenues for discovering new antibacterial and antifungal agents. Here, we identify and structurally analyze the product of the BGC, which encodes a class II lanthipeptide in the thermophilic bacterium sp. DSM 45891. Heterologous co-expression of the lanthipeptide synthetase TlaM resulted in modification of the two precursor peptides TlaA1 and TlaA2, which share 58% identity. TlaA1 was dehydrated seven times and TlaA2 six times. In both peptides, four thioether rings were formed with two overlapping DL-(methyl)lanthionine rings at the C-terminus. Both peptides also contain two central and N-terminal non-overlapping DL-methyllanthionines. These findings demonstrate that these peptides deviate from the general rule of stereoselective LL-(methyl)lanthionine formation from a DhxDhxXxxXxxCys motif (Dhx = dehydroalanine or dehydrobutyrine). AspN-cleaved TlaM-modified TlaA1 displayed anti-microbial activity against a subset of bacteria including Gram-negative ESKAPE pathogens. We named the lantibiotic thermolanthin. - Source: PubMed
Publication date: 2026/04/04
Weir EnleyonaZhu Lingyangvan der Donk Wilfred A - The evolution of Spinal Cord Stimulation (SCS) from simple bipolar programming to sophisticated physiologic closed-loop technology has introduced significant complexity into programming and associated reimbursement coding and billing. To address these challenges, the American Society for Pain and Neuroscience (ASPN) developed this evidence-based consensus document to establish best practices for integrating advanced SCS programming into clinical workflows. - Source: PubMed
Publication date: 2026/01/18
Deer Timothy RNairizi AliHunter Corey WKalia HemantPope Jason ECornidez Eric GSayed DawoodSmith Gregory LGoree Johnathan HAntony Ajay BStaats Peter SGilligan ChristopherKarcz MarcinTrainor DrewBroachwala Mustafa YReynolds DustinBloomfield AndrewVu Chau MLad Shivanand PTrainer RobertMonacelli CarlaDevers JolaynePetersen Erika A