CCRN4L ELISA kit
- Known as:
- CCRN4L Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CCRN4L-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CCRN4L ELISA kit
Related genes to: CCRN4L ELISA kit
- Gene:
- NOCT NIH gene
- Name:
- nocturnin
- Previous symbol:
- CCRN4L
- Synonyms:
- CCR4L, Ccr4c, NOC
- Chromosome:
- 4q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-14
- Date modifiied:
- 2015-08-25
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- Circadian rhythms are conserved biological timekeeping mechanisms crucial for the temporal compartmentalization of metabolic processes. However, the molecular pathways by which circadian rhythms are regulated within metabolism are not fully understood. Nocturnin (NOCT) is a highly rhythmic, clock-controlled NADP(H) phosphatase that has been implicated in numerous metabolic phenotypes. While it is known that NOCT significantly impacts the cellular NADP(H) and NAD(H) pools , NOCT's impact on their concentrations and rhythmicity has not yet been established. In fact, the rhythmicity of NADH, NADP , and NADPH have yet to be quantified in mammalian nucleated cells. Here, we determined both the whole cell and mitochondrial NAD(H) and NADP(H) rhythms in wild-type and mouse livers. Unexpectedly, we found a robust rhythm in the mitochondrial NADP(H)/NAD(H) ratio that is antiphase to the respective whole cell rhythm. While loss of NOCT increases the amplitude of the whole cell NADP(H)/NAD(H) rhythm, the mitochondrial rhythm is completely damped in mice. The constitutively higher relative NADP(H) within mitochondria drives steroidogenesis, leading to an increased amplitude of plasma corticosterone. Both the acute increase in plasma corticosterone and the disruption of mitochondrial cofactor rhythms caused by loss of NOCT lead to widespread changes in hepatic metabolism. Collectively, we found that NOCT's control of mitochondrial NADP(H)/NAD(H) rhythms is a novel regulator of steroid amplitude and downstream metabolic rhythms. - Source: PubMed
Publication date: 2026/07/28
Palluth LaurenLaothamatas IsaraNguyen Tammy-NhuRasmussen Emil SZacharias Lauren GVelasquez Mauricio JIñigo-Vollmer MelissaFu XiaorongMathews Thomas PMcDonald Jeffrey GBurgess Shawn CTakahashi Joseph SGreen Carla B - Endovascular therapies are increasingly becoming the primary approach for treating cerebrovascular disorders. However, these procedures rely on DSA, which provides limited visualization due to inherently limited spatial resolution. Intravascular optical coherence tomography (OCT) enables 3D, high-resolution visualization of coronary arteries, allowing detailed assessment of the vascular wall, atherosclerotic plaque characteristics, and stent deployment. This has lead cardiology societies to recommend intravascular OCT for the management of complex coronary interventions (level 1A evidence). OCT is now being adapted for neurointerventional applications. A dedicated neuro-OCT (OCT™, Spryte Medical) technology, designed to enable OCT imaging in tortuous intracranial arteries, has been recently introduced. Initial studies showed OCT safety and feasibility for neurovascular use and explored its potential value for improved intracranial vascular imaging in stroke settings. The successful integration of OCT technology into clinical workflows requires standardized principles for image acquisition and interpretation. This video describes how to use OCT in clinical practice. VIDEO. - Source: PubMed
Publication date: 2026/07/30
Forestier GéraudCancelliere Nicole MLylyk PedroUghi Giovanni JPereira Vitor M - NADP(H) and NAD(H) are essential cofactors involved in nearly 500 metabolic reactions, making them fundamental to cellular function and redox homeostasis. Loss of redox homeostasis through alterations in NADP(H) regulation has been implicated in various diseases, including neurodegenerative disorders and cardiovascular diseases. The levels of these metabolites are tightly regulated and highly compartmentalized. Nocturnin (NOCT), a circadian clock-controlled phosphatase, hydrolyzes both oxidized and reduced forms of NADP(H) and exists in cytosolic and mitochondrial forms. Here, we compare the activity of and mammalian NOCT, which reveals a novel redox-dependent regulatory mechanism in mammals. Mammalian NOCT undergoes cysteine-mediated disulfide bond formation, leading to enzyme oligomerization and inactivation, while reduction of these cysteines restores NOCT to its monomeric, active form. In contrast, NOCT lacks these regulatory cysteines, does not oligomerize, and remains constitutively active. We show that oligomerization of mammalian NOCT occurs physiologically in the mitochondria while the comparatively highly reduced environment of the cytosol keeps NOCT in its monomeric conformation. Furthermore, sequence analysis reveals that mitochondrial NOCT emerges predominantly in mammals and coincides with the acquisition of redox-sensitive cysteines, highlighting a possible adaptation to oxidative metabolic environments. These findings suggest that mammalian NOCT functions as a redox sensor, dynamically modulating NADP(H) availability in response to oxidative stress. Understanding NOCT's evolution and regulation offers new insights into NADP(H) metabolism and its broader implications for oxidative stress. - Source: PubMed
Publication date: 2026/05/30
Olivas-Rasmussen Crystal AGao PengRasmussen Emil SGreen Carla B - Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is an effective treatment for extreme obesity, but some patients experience inadequate weight loss or weight regain. This study aimed to identify blood biomarkers that predict effective weight loss following RYGB. - Source: PubMed
Publication date: 2026/03/09
Mahjoubin-Tehran MaryamJamialahmadi TannazSukhorukov Vasily NAlmahmeed WaelKroh MatthewSahebkar Amirhossein - Obsessive-compulsive disorder (OCD) and allergic diseases co-occur far more often than expected, yet genome-wide genetic correlations are typically modest or negative. The objective of this study was to test whether OCD and allergic diseases show convergence at the level of pre-specified biological pathways, especially synaptic pruning and circadian regulation, rather than at the level of broad genome-wide correlation. - Source: PubMed
Publication date: 2026/05/27
Cheung Ngo