ABCA3 ELISA kit
- Known as:
- ABCA3 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ABCA3-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ABCA3 ELISA kit
Related genes to: ABCA3 ELISA kit
- Gene:
- ABCA3 NIH gene
- Name:
- ATP binding cassette subfamily A member 3
- Previous symbol:
- ABC3
- Synonyms:
- ABC-C, EST111653, LBM180
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-08-08
- Date modifiied:
- 2015-11-13
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- Chronic obstructive pulmonary disease (COPD) is a global health issue driven by chronic inflammation. Although Qibai Pingfei Capsule (QBPF) shows clinical efficacy in COPD, its multi-component, multi-target nature complicates mechanistic studies. A COPD rat model was established using smoking, hypoxia, and swimming. Metabolomics and lipidomics based on ultra-high performance liquid chromatography coupled with electrospray ionization triple quadrupole-linear ion trap mass spectrometry (UHPLC-ESI-QTRAP-MS) revealed that QBPF alleviated COPD-associated metabolic disruptions, particularly in energy, amino acid, and lipid metabolism. Multivariate statistical analysis, cluster analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis intended to obtain ATP binding cassette subfamily A member 3 (ABCA3) as a key target. Western blot (WB) analysis, enzyme-linked immunosorbent assay (ELISA), and immunohistochemistry (IHC) confirmed that QBPF upregulated the expression of ABCA3 and peroxisome proliferator-activated receptor gamma (PPARγ) in COPD rats, downregulated p-nuclear factor kappa B p65 (p-p65), and subsequently downregulated the expression of inflammatory factors such as interleukin-1 beta (IL-1β) and interleukin-17A (IL-17A), thereby alleviating COPD pulmonary inflammation. After transfection with small interfering RNA (siRNA) ABCA3, the expression of ABCA3 was knocked down and the upregulation of PPARγ by QBPF was weakened, thereby affecting its inhibitory effects on p65, IL-1β, and IL-17A. Our research results indicated that QBPF could upregulate the expression of ABCA3, leading to an increase in PPARγ and a decrease in p-p65, ultimately improving pulmonary inflammation in COPD. - Source: PubMed
Publication date: 2026/04/24
Tang SiyuLiu MengxiangGao YatingXie JinghuiDa WenkaiYang QinjunTong XiangliFang XiangmingLi ZegengZhu Jie - Due to the global obesity crisis, increasing numbers of women enter pregnancy with overweight or obesity. Their offspring are at greater risk of respiratory complications at birth due to metabolic changes that impact lung development that may reduce capacity for surfactant production. We hypothesize that a high-fat-high-energy diet (HF-HED) negatively impacts late gestation fetal lung development. - Source: PubMed
Publication date: 2026/04/27
Lock Mitchell CHuber Hillary FLi CunOrgeig SandraNathanielsz Peter WMorrison Janna L - Precise labeling of alveolar type 2 (AT2) cells is essential for elucidating lung development and injury responses. In this study, we evaluated Abca3 and Etv5-based genetic strategies for labeling AT2 cells in murine models. Using targeted genetic approaches, we generated Abca3-rtTA and Etv5-rtTA knock-in mouse lines and crossed them with pTRE-H2BGFP to create inducible reporter models driven by Abca3 or Etv5. Labeling specificity and efficiency were assessed by flow cytometry and co-immunostaining. Our results show that both Abca3 and Etv5 strategies faithfully label AT2 cells across developmental stages and following lung injury. Comprehensive analyses confirmed the high specificity and efficiency of labeling. These Abca3- and Etv5-driven systems offer robust tools for investigating AT2 cell biology and pathology and may serve as effective drivers for tetO-mediated gene knockout or overexpression studies specifically in AT2 cells in mouse models. - Source: PubMed
Publication date: 2026/02/06
Liu XueZhang XuexiLi ZekunKulur VrishikaLiu NingshanLiang JiurongJiang Dianhua - Malignant cancers exhibit distinct lipid metabolic features that support tumor initiation and progression. Glioblastoma (GBM) is an aggressive brain tumor driven by GBM stem cells (GSCs), which are responsible for tumor development and therapy resistance. However, effective treatments targeting vulnerable metabolic pathways in GSCs have not yet been developed. Here, we demonstrate that the ATP-binding cassette transporter A3 (ABCA3) maintains lipid metabolic balance in GSCs. ABCA3 is highly expressed in GSCs, where lipid biosynthesis is particularly active. Knocking down ABCA3 significantly reduces cell growth, self-renewal, viability, and tumor growth after intracranial implantation. These changes are caused by a profound disruption of lipid metabolic balance, as demonstrated by RNA sequencing and liquid chromatography-time-of-flight mass spectrometry, which revealed widespread alterations in lipid metabolism genes and lipid composition. Mechanistically, ABCA3 knockdown inhibits sterol regulatory element-binding protein 1 (SREBP1) signaling by accumulating acylcarnitines (ACs) caused by phospholipid breakdown. The increased ACs induce the production of mitochondrial reactive oxygen species, which activate adenosine monophosphate-activated protein kinase (AMPK), resulting in the inhibition of SREBP1 signaling and reduced GSC fitness. Overall, these findings suggest that ABCA3 maintains lipid metabolic balance in GSCs, and disrupting this function triggers AMPK-dependent suppression of SREBP1 signaling. - Source: PubMed
Publication date: 2026/03/25
Kim Jun-KyumPark Min GiHam Seok WonYoon SeunghyunKim SuaJang JunseokKim HyejinHong NayoungPark Jong MinPark Cheol GyuPark Min JiChoi Sang-HunKim Jung YunJeon Hee-YoungSeo SunyoungLee Seon YongLee YeriCho Hee JinGwak MinseoKim Eun-JungEun KiyoungShin Yong JaeNam Do-HyunKim Se HoonYoo Seung JunKim Hyunggee - Three-dimensional (3D) organoid models, such as alveolospheres, are unique tools for investigating the mechanisms underlying emphysema. However, high inter-organoid heterogeneity hampers consistent results in emphysema research and drug testing. - Source: PubMed
Publication date: 2026/03/17
Guecamburu MarinaPavot ArthurLegrix AmélieJeannière CarolineBelaroussi YanissThumerel MatthieuSamaniego EmmaBegueret HuguesMaucort GuillaumeDecoeur FannyDupuy Jean-WilliamRaymond Anne-AurélieEsteves PaulineGrassion LeoDournes GaelBerger PatrickMaurat EliseRaasch KatharinaLatouille EloïseStuder VincentDupin IsabelleHenrot PaulineZysman Maéva