BMP4 ELISA kit
- Known as:
- BMP4 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-BMP4-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- BMP4 ELISA kit
Related genes to: BMP4 ELISA kit
- Gene:
- BMP4 NIH gene
- Name:
- bone morphogenetic protein 4
- Previous symbol:
- BMP2B
- Synonyms:
- -
- Chromosome:
- 14q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
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- Mesenchymal stromal cells from equine ovarian follicular aspirates represent a promising source for cell-based therapies. However, the age of the donor mare may alter their biological properties and therapeutic potential. This study aimed to evaluate the effect of age on MSCs from ovarian follicular aspirates of young (< 10 years, n = 5) and aged (≥ 18 years, n = 5) mares. MSCs were isolated, expanded, cryopreserved at passage 3, and subsequently thawed to evaluate proliferation, immunophenotype, differentiation capacity, and gene expression profiles. Proliferation rates, total cell yield, and mean time to reach 80% confluence showed no significant differences between the age groups. Flow cytometry analysis confirmed uniform expression of MSC-associated positive markers (CD90, CD29) and absence of CD45, CD19 and MHC-II in both groups. Trilineage differentiation assays demonstrated that cells retained trilineage differentiation capacity at a qualitative level regardless of donor age. However, transcriptomic analysis using RT Profiler PCR Array and qPCR validation revealed substantial differences in gene expression. MSCs from young mares exhibited significant upregulation (fold change ≥ 2; p < 0.05) of stemness-related genes (LIF, POU5F2), regulators of adipogenic and chondrogenic differentiation (PPARγ, SOX9), and cell migration-associated markers (MCAM, VCAM). Conversely, MSCs from young mares showed decreased expression (fold change ≤ 0.5; p < 0.05) of lineage-specific differentiation genes (TBX5, SLC2A4), inflammatory mediators (IL6), and senescence-associated markers (ITGAX, BMP4, SMAD3). These findings suggest that, although some MSC characteristics are preserved, donor age significantly alters the transcriptomic profile of equine follicular MSCs, which could affect their therapeutic efficacy. - Source: PubMed
Publication date: 2026/05/29
Muñoz-García C CSoriano-Campos M PLuis-Calero MGallardo-Soler AGonzález-Fernández LMacías-García B - To evaluate the effects of Bone Morphogenetic Protein 4() overexpression mediated by an adenoviral vector on immunophenotype features, migration ability, colony-forming ability, and early osteogenic differentiation potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs). - Source: PubMed
Guan Xiao-YunLi Pei-LinWu Ying-YingTang JieXu Run-XiangZhu HengDing Li - Dermal papilla cells (DPCs) serve as the regulatory center for hair follicle (HF) development, and their proliferation is critical in HF growth studies. Research has shown that long non-coding RNA (lncRNA) can be involved in the regulation of the HF growth cycle. This study aims to elucidate the molecular mechanisms by which lncRNA regulates HF formation. - Source: PubMed
Publication date: 2026/06/01
Hui ZhouWang ShanheSu RuiSong YuxuanZhang XiyunLv XiaoyangSun Wei - Morphogenesis depends on spatial and temporal coordination of signaling pathways, yet context-specificity in interactions among these pathways during cartilage and bone differentiation remains poorly understood. Here we map cellular and histological localization of regulatory proteins forming core craniofacial developmental pathways of the zebra finch (Taeniopygia guttata) to provide insight into their functional roles during beak morphogenesis. - Source: PubMed
Publication date: 2026/05/31
Duckworth Renée ABritton Sarah ELee Cody AChenard Kathryn CBadyaev Alexander V - Postoperative wound healing, especially after anal-fistula surgery, poses unique clinical challenges due to the complex anal anatomy and the need for accelerated recovery. Although the ethnomedicinal plant Cayratia japonica (Thunb.) Gagnep. has long been recognized for its wound-healing properties, its molecular basis and therapeutic potential remain poorly defined. Here, an optimized C. japonica hydrogel (CJH) markedly improved clinical outcomes, while temporal multi-omics profiling underscored the necessity of stage-specific therapeutic adaptation. Specifically, CJH-derived Luteolin 7-glucuronide was found to enhance fibroblast proliferation via BMP4 protein engagement and downstream signaling activation, thereby accelerating wound remodeling. - Source: PubMed
Publication date: 2026/05/27
Chen QiHou YiAbdulrasol SulaimanHe RongLiu TingtingXu YinLuo JiawenShimizu KuniyoshiRuan YangZheng XuepingZhang Chaofeng