CASP14 ELISA kit
- Known as:
- CASP14 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CASP14-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CASP14 ELISA kit
Related genes to: CASP14 ELISA kit
- Gene:
- CASP14 NIH gene
- Name:
- caspase 14
- Previous symbol:
- -
- Synonyms:
- MICE, MGC119078, MGC119079
- Chromosome:
- 19p13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-11-09
- Date modifiied:
- 2016-10-05
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- The aryl hydrocarbon receptor (AHR) is a regulator of epidermal homeostasis and a promising target for cosmetic and dermatological ingredients aimed at improving skin barrier function and reducing inflammation. This study investigated the potential of the natural polyphenol trans-resveratrol (RSV), a compound of cosmetic interest, to modulate downstream AHR signalling and restore epidermal integrity in a model of skin compromised by a pro-inflammatory environment. - Source: PubMed
Publication date: 2026/08/09
Dijkhoff Irini MKeshavan SandeepDaré Regina GPetri-Fink AlkeEeman MarcTessier AgnèsRothen-Rutishauser Barbara - This study aimed to identify genetic markers for body weight in adult male Dongfeng sika deer (Cervus nippon) using a genome-wide association study (GWAS). A cohort of 266 healthy, five-year-old stags was phenotyped and genotyped via whole-genome resequencing. Population structure was assessed, and a mixed linear model (MLM) was employed for association testing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of candidate genes. The GWAS identified twelve genome-wide significant SNP loci, which were annotated to seven candidate genes: ERC2, LOC122708028, FHIT, CASP14, UBE3A, NRXN3, and GABRA5. Functional enrichment analyses revealed these genes are significantly involved in the γ-aminobutyric acid (GABA)ergic synaptic transmission pathway and pathways related to DNA damage repair and cell cycle regulation. This study provides insights into the genetic mechanisms underlying body weight traits in adult male Dongfeng sika deer and offers a reference for subsequent functional exploration of candidate genes. - Source: PubMed
Publication date: 2026/06/11
Zhang XinyuanZhang YanZhao LiepingZhao YaoQian Wen-XiGai GuanghuiSong JunDu PeizeHan HuanshengZhang Zhen - Real-valued inter-residue distance maps provide essential spatial information for understanding protein folding mechanisms and guiding downstream applications such as function annotation, drug discovery, and structural modeling. However, existing prediction methods often struggle to capture long-range dependencies and to maintain topological consistency across different structural scales. To address these challenges, we propose a novel prediction framework that integrates a Mamba architecture, based on a selective state space model, to effectively model global interactions, and incorporates the Kolmogorov-Arnold Network (KAN) to enhance nonlinear structural representation. Extensive experiments on standard benchmark datasets, including CASP13, CASP14, and CASP15, demonstrate prediction accuracies of 86.53%, 85.44%, and 82.77%, respectively, outperforming state-of-the-art approaches. These results indicate that the proposed framework substantially improves the fidelity of real-valued distance prediction and offers a promising tool for downstream structural and functional studies. - Source: PubMed
Publication date: 2026/01/27
Dong BenzhiHua YumengHou ChangXu DaliWang Guohua - Breast cancer remains one of the leading causes of cancer-related deaths among women worldwide. The chemotherapeutic drugs used in treatment often have serious side effects. In light of their anticancer potential, thiazolidinedione (TZD) derivatives are considered to be promising candidates for the development of novel antitumor agents. The objective of this study is to synthesize and produce two sets of TZD derivatives by combining the structural features of microtubule-targeting drugs used in breast cancer treatment, and to determine their molecular docking, molecular dynamics simulations, ADMET profile, antiproliferative, and apoptotic effect potential. In the present study, PZ-11 was determined by xCELLigence analysis to have the highest antiproliferative potential among all compounds tested on MCF-7 breast cancer cells. The cytotoxic activity of the synthesized compounds was evaluated against MCF-7 breast cancer cells, revealing IC values of 29.44 μM for PZ-9 and 17.35 μM for PZ-11, compared to 6.45 μM for the reference drug vincristine. Analysis of the gene expression of the PZ-11 compound, which has a stronger cytotoxic effect potential, showed that PZ-11 significantly downregulates , and , while upregulating pro-apoptotic genes such as , and . PZ-11's binding affinities were screened using a molecular docking workflow via KNIME. The robust and persistent interactions between PZ-11 and AIF were substantiated by molecular dynamics simulation. It is demonstrated by ADMET predictions that PZ compounds possess suitable pharmacokinetic properties. PZ-11 is a promising TZD-based anticancer drug candidate against breast cancer cells, as determined by computational and experimental analysis. However, further validation is required through analysis to support these findings. - Source: PubMed
Publication date: 2025/12/23
Zarrin PouriaGado SarahFarhang Boroujeni AliGadaşlı IbrahimBozkurt Fatma ZeynepCansaran-Duman DemetMutlu PelinAtes-Alagoz Zeynep - Myasthenia gravis (MG) is a chronic autoimmune neuromuscular junction disorder mediated by autoantibodies. Existing diagnostic methods mainly rely on serum antibody detection and electrophysiological testing, which are limited by invasiveness and suboptimal sensitivity and specificity. This study aimed to identify potential urinary biomarkers for noninvasive MG diagnosis using proteomics. - Source: PubMed
Publication date: 2026/01/09
Yang JingYang XiZhu Zhen-KunShen LiangSan Shi-GeXiao LianchenYe FanWang Chun-HuaMeng Kun