ADAM28 ELISA kit
- Known as:
- ADAM28 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ADAM28-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ADAM28 ELISA kit
Related genes to: ADAM28 ELISA kit
- Gene:
- ADAM28 NIH gene
- Name:
- ADAM metallopeptidase domain 28
- Previous symbol:
- -
- Synonyms:
- eMDCII, MDC-Lm, MDC-Ls, ADAM23
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-29
- Date modifiied:
- 2019-03-22
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- This study aims to elucidate the regulatory mechanisms of host genetics on the porcine gut microbiota and their subsequent impact on the feed conversion ratio (FCR). While initial genome-wide association studies (GWAS) did not identify significant SNPs directly associated with FCR, we investigated the gut microbiota as a potential intermediate phenotype influencing feed efficiency. Nonmetric multidimensional scaling (NMDS) based on Bray–Curtis distances demonstrated a distinct separation in microbial community structure between the high-feed conversion ratio (HFCR) and low-feed conversion ratio (LFCR) groups (stress = 0.19), suggesting a link between FCR and gut microbial composition. Furthermore, a significant, albeit weak, negative correlation was observed between the genomic relatedness matrices and microbial Bray‒Curtis dissimilarity ( = −0.0143, = 0.0031), indicating host genetic control over the microbiome. Microbiome genome-wide association study (mGWAS) identified 117 significant SNPs associated with 28 microbial taxa. Functional annotation highlighted eight candidate genes () involved in the regulation of taxa, including . Collectively, these findings establish that the gut microbiota is a heritable trait influenced by the host genome, providing novel targets for breeding strategies designed to optimize microbial composition for improved feed efficiency. - Source: PubMed
Publication date: 2026/03/12
Wu QitianWang XiaoqingMu QimingTian JingjingWang HailingYang JiayiPeng ZhenGao LiliGao PengfeiZhao Fuping - Testicular tissue displays the most complex transcriptome across all tissues, with over 2000 genes exhibiting testis-enriched expression patterns. However, the functional ambiguity of such genes limits our understanding of spermatogenesis and male fertility. Here, we reanalyzed testicular gene expression profiles from patients with impaired spermatogenesis and identified that reduced expression of the testis-specific gene C3ORF22 was correlated with spermatogenic defects in humans. We showed that the murine ortholog BC048671 was predominant expressed in round spermatids, and its protein is present in spermatozoa. BC048671 knockout (KO) mice exhibited normal fertility, sperm morphology, and sperm motility. Intriguingly, RNA-Seq analysis revealed that BC048671 was the most markedly dysregulated gene in KO testes. Although proteomic analysis reveals the down-regulated ADAM family members (e.g., ADAM28 and ADAM2) in BC048671-null sperm, expression of the key downstream effector ADAM3 remained unaffected. These findings indicate that BC048671/C3ORF22 exhibits functional redundancy in spermatozoa. Although C3ORF22 is dispensable for male fertility, we consider it essential to report such negative results to guide researchers to prioritize efforts toward genes critical for human fertility. - Source: PubMed
Publication date: 2025/10/11
Du ShiyueLiu YongfuWang LeShi LiuliuZhao XiaoyingYang ZhongchengYuan WeiDeng XiaoyingLiu JiahuaFeng ShengleiChen Rui - Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with pediatric ALL having a ~90 percent cure rate, while the adult cure rate is considerably lower. B-cell acute lymphoblastic leukemia (B-ALL) is the most common subtype of ALL and is generally treated through a variety of chemotherapy drugs that can cause undesired side effects, adverse events, or other complications. Consequently, there is a need for improved understanding of the shared gene expression profiles and underlying molecular mechanisms shared among various B-ALL subtypes. In this study, 259 publicly available RNA-sequencing samples were evaluated and retrieved from the NCBI Gene Expression Omnibus (GEO) database and then pre-processed using a robust computational workflow. Differential gene expression, pathway enrichment, marker prediction, and drug repurposing analyses were then performed to facilitate a better mechanistic understanding of disease. We found both previously identified as well as novel differentially expressed genes. Specifically, we observed upregulation in the , , and genes; while downregulation was observed for the , , and genes. We identified multiple pathways, including "Integrins in Angiogenesis", to be significantly affected in B-ALL. We then used these significant pathways to predict and rank 306 existing therapeutic targets that could potentially be repurposed for B-ALL, including three that have not been evaluated in human clinical trials. Using a tree-based classification algorithm, we also predicted ADAM28 as a possible mechanistic marker. The results of this study have potential implications for patients who have been diagnosed with B-ALL by providing improved mechanistic understanding and information on possible diagnostics and repurposed therapeutics for B-ALL. - Source: PubMed
Publication date: 2025/08/28
Wilkins Makayla R KPickett Brett E - Tripterygium glycoside tablet (TGT), a first-line anti-inflammatory drug for rheumatoid arthritis (RA), is severely limited in clinical use by male reproductive toxicity with unclear mechanisms. This study aimed to confirm TGT's anti-RA efficacy, characterize its reproductive toxicity in collagen-induced arthritis (CIA) rats, and elucidate whether the NELL2-Lumicrine system mediates such damage. - Source: PubMed
Publication date: 2025/08/26
Guo LiLi SiqiLi ZehuiLi YuanLi JiashanCheng HuitingLu YuanLin NaXu Ying - Mesenchymal stem cells (MSCs) represent a potential cellular therapy for multiple sclerosis (MS). It has been suggested that MSCs from patients with MS have lower immunomodulatory properties than those from healthy controls (HCs). The aims of this study were to compare the immunomodulatory abilities of MSCs from patients with MS and HCs against autologous immune cells and to identify potential targets affecting this ability. - Source: PubMed
Publication date: 2025/08/28
Tanasescu RaduFrakich NanciGumireddy KiranmaiMajumdar SonaliThevathas SarahJones RhodriGran BrunoOnion DavidWickramasinghe Pryiankara JayamannaChang CherryKossenkov Andrew VSpendlove IanColombo Sergio LShowe Louise CConstantinescu Cris S