AOC3 ELISA kit
- Known as:
- AOC3 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-AOC3-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- AOC3 ELISA kit
Related genes to: AOC3 ELISA kit
- Gene:
- AOC3 NIH gene
- Name:
- amine oxidase copper containing 3
- Previous symbol:
- -
- Synonyms:
- VAP1, HPAO, VAP-1
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-03
- Date modifiied:
- 2019-01-18
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- The proteolytic cleavage of membrane-bound proteins, ectodomain shedding, functionally expands the reservoir of proteins/peptides available for endocrine crosstalk, and metabolic regulation. However, the functional understanding of secreted proteoforms, including whether they act synergistically or antagonistically with their membrane precursors, is often unknown. We aimed to develop a novel viral vector-based gene delivery platform enabling characterization of both membrane-bound and soluble proteoforms in adipocytes, independent of endogenous shedding. To this end, we elected amine oxidase copper-containing 3 (AOC3) as a target for validation. - Source: PubMed
Publication date: 2026/05/07
Tavanez Ana RitaEgedal Nadia MeinckeStanic NatasaTopel HandeKornfeld Jan-Wilhelm - Gastric cancer (GC) poses a significant health threat, and alterations in Fatty acid β-oxidation (FAO) may influence its progression. However, the precise mechanisms underlying this association remain unclear. FAO-related genes were analyzed using transcriptomic datasets from databases of GEO and TCGA. Totally 160 FAO-associated genes were identified, and a risk scoring model was subsequently established to stratify patients into groups of low- and high-risk. Immune characteristics, drug sensitivities, and hub genes, including IL-6, were assessed. Subsequently, immunoblotting and immunohistochemistry were performed on GC cell lines and tissue samples to evaluate IL-6 expression. Analysis of the TCGA and GEO databases revealed a FAO-related gene signature comprising ACADS, ACO2, CPT2, SLC22A5, AOC3, CD36, CIDEA, G0S2, GABARAPL1, and SERINC1. We also examined gene mutations and constructed a prognostic risk scoring model with validation achieved through a nomogram to predict gastric cancer risk. Immune infiltration analysis and drug sensitivity testing (e.g. AG-014699, Axitinib, BX-795, and Cisplatin) were also conducted. IL-6 emerged as a core gene with significant expression difference across cellular and tissue levels. FAO plays a critical role in the prognosis of GC, and IL-6 may serve as a key biomarker for diagnosis and therapeutic strategies. - Source: PubMed
Publication date: 2026/05/02
Qu ChaoYuan XuetaoYang ShutingQiao YifanZhang RenjianzhiWu YunhuaZhu MengkeDu JiayinLi GanZhang RuiSun XuejunLi Xuqi - Vascular adhesion protein-1 (VAP-1), also known as copper-containing amine oxidase 3 (AOC3), is an enzyme implicated in the pathogenesis of various diseases. Increasing evidence highlights VAP-1 as a promising therapeutic target, particularly for the treatment of inflammatory disorders and diabetic complications. We have synthesised a series of compounds in which a heterocycle or a benzene-fused heterocycle is connected a hydrocarbon spacer to a glycine amide, semicarbazide, or fluoroallylamine moiety. These functional groups are believed to act as reactive "warheads", forming covalent bonds with the topaquinone cofactor at the enzyme's active site. Screening was initially conducted using bovine plasma amine oxidase (AOC4), an enzyme structurally closely related to VAP-1 (AOC3) and also referred to as secretory VAP-1 (sVAP-1). Selected compounds were subsequently evaluated for their ability to inhibit VAP-1 activity in human plasma. The results showed that glycine amide and semicarbazide analogs generally exhibited stronger inhibition of the bovine AOC4 than of the human AOC3. In contrast, fluoroallylamines displayed comparable or even greater inhibitory potency toward the human enzyme. Overall, fluoroallylamines with nanomolar IC values were identified as the most potent inhibitors of human VAP-1, whereas glycine amides, which act as substrate inhibitors, were the least effective. In assays evaluating inhibition of the related enzyme diamine oxidase (AOC1) as well as monoamine oxidases A and B (MAO A and MAO B), the glycine amides displayed relatively high selectivity for human VAP-1. The semicarbazides, however, also showed strong inhibitory activity against AOC1. Several of the fluorinated allylamines tested were identified as highly potent, well-balanced dual inhibitors of human VAP-1 and MAO B, with ()-2-({3-[(1-benzotriazol-1-yl)methyl]phenoxy}methyl)-3-fluoroprop-2-en-1-amine (94) being the most effective. Compounds with this dual inhibitory profile are thought to exert particularly beneficial effects in the treatment of inflammatory conditions. - Source: PubMed
Publication date: 2026/01/28
Pöstges TimoKampschulze JanHanekamp WalburgaBermúdez MarcelLehr Matthias - Piperine is a common anti-ischemic compound and an active ingredient of herbal medicine for various ailments. It is widely sourced and affordable. However, its bioactivity and anti-ischemic effects on retinal ischemic injury are unknown. The chemical-gene interactions of piperine were analyzed using data from "SwissTargetPrediction," "Binding DB", and "TargetNet" databases. Gene expression data from GSE43671 dataset and the Kyoto encyclopedia of genes and genomes (KEGG) were used for differential gene and ontology analyses. To evaluate the activation of disease pathways, by analyzing gene sets and applying weighted gene co-expression networks to differential gene interaction data. Additionally, molecular complex detection analyses of retinal ischemia and control samples were performed to determine which genes are affected by piperine, to compare gene expression differences, and to map receiver operator characteristic data. Utilizing network pharmacology and transcriptome sequencing, this study elucidates the targets and pathways affected by pharmacological interventions involving piperine in retinal ischemia injury. 176 target genes connected to piperine were identified and retrieved. Screening of 8 hub genes using machine learning. Through screening, we detected disease-associated genes, differential genes, and drug targets, and pinpointed two biomarker genes, Aoc3 and Gabra3. We found that piperine may have a protective effect on retinal ischemic injury. Consequently, piperine may modulate retinal ischemic injury through specifically targeting Aoc3 and Gabra3 for retinal protection. - Source: PubMed
Publication date: 2026/02/05
He QianxiongWang YiShi YuanjiangChen YannanLi BinXin Xiaorong - Colorectal cancer (CRC) is a prevalent and lethal malignancy worldwide. Despite extensive research, core genes for diagnosis and prognosis in CRC remain to be fully elucidated. This study aims to identify novel gene biomarkers for CRC diagnosis and prognosis based on the GEO and TCGA datasets. Integration of TCGA and GEO datasets revealed 197 common differentially expressed genes (DEGs) between CRC tumor and normal samples. Functional enrichment analysis implicated these DEGs in biological processes and signaling pathways critical to CRC progression, including cell cycle regulation and nuclear division. Protein-protein interaction (PPI) network analysis identified 17 hub genes from DEGs, including , , , , , , , , , , , , , , , , and . All 17 hub genes demonstrated high diagnostic value (AUC > 0.85), including (AUC = 0.944). Based on the Cox proportional hazards regression, an 8-gene prognostic signature (, , , , , , , ) effectively stratified patients by survival risk, with a 5-year AUC of 0.71. In vitro, knockdown triggered cell cycle arrest, thereby suppressing the proliferation of colorectal cancer cells. This study validated as a dual-purpose biomarker for CRC diagnosis and favorable prognosis, highlighting its potential utility in clinical management. - Source: PubMed
Publication date: 2025/12/09
Zou YaoZou QuanLi Zhen