ATP4b ELISA kit
- Known as:
- ATP4b Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ATP4b-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ATP4b ELISA kit
Related genes to: ATP4b ELISA kit
- Gene:
- ATP4B NIH gene
- Name:
- ATPase H+/K+ transporting subunit beta
- Previous symbol:
- -
- Synonyms:
- ATP6B
- Chromosome:
- 13q34
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-26
- Date modifiied:
- 2018-04-23
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- Kidney stone disease is a common metabolic disorder with high recurrence rates and an associated risk of chronic kidney disease, while proton pump inhibitors (PPIs) are widely used medications with potential links to renal complications. Previous observational studies have suggested an association between PPI use and kidney stones, but the causal relationship remains unclear. This study aimed to investigate the causal effect of PPIs on kidney stones using the Mendelian randomization (MR) analysis. - Source: PubMed
Publication date: 2026/03/18
Jiang YaohuiLin LedeCheng ChaoZhou Liang - Although the global incidence of gastric cancer (GC) has declined over the past 5 years, it remains the fourth leading cause of cancer-related mortality worldwide. Given the molecular heterogeneity of GC, survival outcomes can vary significantly among patients receiving the same treatment at the same stage. Therefore, this study aimed to develop and validate a robust prognostic model for GC that complements the current staging system, to ultimately facilitate better clinical decision-making. - Source: PubMed
Publication date: 2026/02/25
Li MusuSun YueZhang LiaoweiLu ZixuanWo HongmeiShao FangTang ShaowenZhao YangDai JunchengYi Honggang - The vertebrate stomach is responsible for the secretion of hydrochloric acid (HCl) and is the first site of protein digestion in the gut. The secretion of HCl occurs through the gastric proton pump, a hydrogen-potassium ATPase (HKA) composed of α and β subunits encoded by the ATP4A and ATP4B genes, respectively. In the past, the evidence for the role of the gastric acid secretion in nutrient digestion and absorption, growth and postprandial energy metabolism has been gathered using indirect methods such as diet modulation experiments, or the use of proton-pump inhibitors. These methods may introduce confounding factors and lead to erroneous conclusions. With the aim of directly observing the role of the gastric proton pump, we have generated a knockout model using targeted gene editing. Using atp4a-null Astyanax mexicanus, we examined the growth rate, nitrogen and energy metabolism, and nutrient assimilation in the presence and absence of gastric acidification. Our results show no effect of knockout on growth or appetite, but a significant reduction in post-prandial nitrogen excretion and oxygen consumption (specific dynamic action). Furthermore, atp4a-/- animals had significantly less body magnesium, calcium, phosphorus and protein, while having more lipid in their carcasses. Importantly, administration of proton-pump inhibitors suppressed growth in both experimental groups, indicating possible off-target effects of these drugs. This study is the first to directly examine the impact of gastric acidification on body composition, growth and metabolism and offers new and targeted evidence on the importance of stomach acidification for gut and digestion homeostasis. - Source: PubMed
Publication date: 2026/04/30
Ferreira Patrícia GomesFlávio HugoWilson Jonathan M - Vocal fold leukoplakia (VFL) is the most common precancerous lesion of laryngeal carcinoma, with variable malignant potential. The pathogenesis of VFL remains incompletely understood. Increasing evidence indicates that laryngopharyngeal reflux, especially bile acid reflux, may drive epithelial transformation. - Source: PubMed
Publication date: 2025/11/29
Zhang Jia-YuBi Tian-JiaoWang Qin-YingZhong Jiang-TaoBao Yang-YangFu Zi-MingChen ZheChen Heng-ChaoCao Zai-ZaiZhou Shui-Hong - Accurate localization of early gastric cancer (EGC) remains challenging due to its morphological resemblance to gastritis. This study presents an artificial intelligence (AI)-assisted bedside diagnostic system to enhance EGC detection by visualizing gastric mucosal acidity. The ATPase H/K transport β subunit (ATP4B), a key regulator of acid secretion, is progressively downregulated in gastric mucosal atrophy and intestinal metaplasia, and significantly reduced in EGC. A surface-enhanced Raman scattering (SERS) microarray is developed to map mucosal pH in 50 patient specimens (1,516 points), with founding compared to pathological images. A multi-model neural network is trained and validated internally on data from 40 patients (1,127 points) and externally validated on 10 patients (389 points). Using an optimal pH threshold of 6.845, the system achieved a strong correlation (R = 0.79) and low error (SSE = 71.83). External validation demonstrated 87.79% sensitivity, 85.04% specificity, 86.89% accuracy, and a κ score of 0.71. This system detected mild pH shifts in atrophic gastritis with intestinal metaplasia, but marked increases with EGC onset, and is able to predict inflammation prior to pathology confirmation. By integrating pH mapping with morphological features, this approach enables precise EGC localization, improves guidance for endoscopic submucosal dissection (ESD), and reduces false-positive diagnoses. - Source: PubMed
Publication date: 2025/10/20
Yan HuihuiLi ZongkuoZhao JingSu LeiJin ZiyiZhao WeiyiDuan RongZhou SuhongruiWang LinglingMao JianshanLu XinliangGai WeihaoDu YangDu QinFang ChengZhao YimingYou YanCai JiantingLi Cong