AREG ELISA kit
- Known as:
- AREG Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-AREG-Eq
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- AREG ELISA kit
Related genes to: AREG ELISA kit
- Gene:
- AREG NIH gene
- Name:
- amphiregulin
- Previous symbol:
- SDGF, AREGB
- Synonyms:
- -
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2015-08-24
Related products to: AREG ELISA kit
Human ELC ELISA KIT 96 TEST
OxiSelect In Vitro ROS/RNS Assay Kit (Green Fluorescence), Trial Size
OxiSelect Methylglyoxal (MG) Competitive ELISA Kit
OxiSelect Methylglyoxal (MG) Competitive ELISA Kit
OxiSelect TBARS Assay Kit (MDA Quantitation), Trial Size
OxiSelect Total Antioxidant Capacity (TAC) Assay Kit, Trial Size
OxiSelect™ In Vitro ROS RNS Assay Kit (Green Fluorescence), Trial Size(1-3)-beta-D-glucan Sandwich ELISA, Double Antibody(1-Kit )11,12-EET DHET Immunoassay Kit(1-Kit )11,12-EET_DHET Immunoassay Kit(1-Kit) 11,12-DHET Immunoassay Kit(1-Kit) 14,15-DHET Human Urine ELISA Kit(1-Kit) 14,15-DHET Hypertension ELISA Kit(1-Kit) 14,15-DHET sEH activity ELISA Kit(1-Kit) 14,15-EET DHET Hypertension ELISA Kit Related articles to: AREG ELISA kit
- Cancer-associated fibroblasts (CAFs) within the tumour microenvironment play a pivotal role in colorectal cancer (CRC) progression and therapeutic resistance. Serine/threonine protein kinase 25 (STK25) exerts multiple roles in tumourigenesis; however, its role in mediating tumour-stroma crosstalk remains largely unexplored. - Source: PubMed
Hou YifanChen JiangboHao HaoSong TongkunSong LinXing PuWeng KaiRan YumengYang XinyingQiao XiaowenChen JieYao RuibinYang HongChen LeiDi JiaboXu KaiSu XiangqianJiang Beihai - SRN001 is a small interfering RNA (siRNA) drug targeting amphiregulin. It was developed using a novel SAMiRNA platform, in which the siRNAs are protected within a self-assembled micelle. This platform eliminates the need for additional excipients to reduce unintended immune reactions. Amphiregulin plays a critical role in tissue repair and immune modulation. By silencing it, SRN001 is expected to be a therapeutic option for various pathologically fibrotic and cancerous diseases. This study aimed to evaluate safety and pharmacokinetics (PK) of SRN001 in humans for the first time. - Source: PubMed
Publication date: 2026/04/22
Park JiyeonLee SeungHwanChung Jae-YongYun SungilPark Han OhPark June YJang InJin - Regulatory T (Treg) cells play crucial roles in myocardial fibrosis, a key pathological feature of diabetic cardiomyopathy (DCM). Deleted in breast cancer 1 (DBC1) has emerged as an inhibitor of the immunosuppressive function of Treg cells in inflammatory states. Here, we studied the subpopulation differentiation and function of Treg cells in the myocardium of DCM and explored the role of DBC1 in Treg cell differentiation. - Source: PubMed
Publication date: 2026/04/13
Lu LinheXu YifeiWen ChangnuanZhao QiancongLi ZhihangLiu JiaqiXu FujieLiu JinchengTang Jiayou - The aryl hydrocarbon receptor (AhR) signaling pathway mediates nephrotoxic compound effects on the kidney, although its mechanisms are incompletely understood. Given that renal tubulointerstitial fibrosis is a central pathological feature of progressive kidney diseases, we investigated AhR-induced profibrotic events at the molecular and cellular levels in human renal tubular epithelial cells (HKC). We found that the AhR activation by the potent agonist 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) promoted epithelial-mesenchymal transition (EMT) and inflammatory responses. This was evidenced by a 56.19% decrease in E-cadherin; 1.87-, 2.39-, and 8.27-fold increases in fibronectin, MMP9, and IL-6, respectively; and a 37.77% enhancement in cell migration. Transcriptome analysis and experimental validations confirmed the consistent dysregulation of these markers. Moreover, we found the profibrotic effects of the known nephrotoxic phytochemical aristolactam I (AL-I) also involving activation of AhR and consistent regulation of the above marker genes, primarily via the AhR. In addition, the transcriptome data further suggested that AhR activation may indirectly induce the profibrotic epidermal growth factor receptor (EGFR) pathway by upregulating AREG, EREG, and TGF-α, indicating crosstalk between AhR and EGFR. Given the wide variety of AhR-active chemicals, these AhR-EMT/inflammation-related markers could be used to screen nephrotoxicity of emerging dioxin-like pollutants and toxic phytochemicals. - Source: PubMed
Publication date: 2025/12/02
Zhu RuihongLiu YiyunHu XiaoxuMa YongchaoYan WeiXu LiXie Heidi QunhuiZhao BinYin JunfaWang Hailin - Biomarkers predicting response to trifluridine/tipiracil (FTD/TPI) with or without bevacizumab (BEV) in refractory metastatic colorectal cancer (mCRC) remain unclear. We identified candidate biomarkers in preclinical models and evaluated their clinical relevance. - Source: PubMed
Publication date: 2026/04/17
Suenaga MMashima TKawata NDan SSeimiya HYamaguchi K