BMP2 ELISA kit
- Known as:
- BMP2 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-BMP2-P
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- BMP2 ELISA kit
Related genes to: BMP2 ELISA kit
- Gene:
- BMP2 NIH gene
- Name:
- bone morphogenetic protein 2
- Previous symbol:
- BMP2A
- Synonyms:
- -
- Chromosome:
- 20p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
- Gene:
- BMP4 NIH gene
- Name:
- bone morphogenetic protein 4
- Previous symbol:
- BMP2B
- Synonyms:
- -
- Chromosome:
- 14q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
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- The current evidence suggests that the formation of pulp stones (PS) has a genetic background. Therefore, the present study aimed to evaluate the association between PS in orthodontically treated patients and single nucleotide polymorphisms (SNPs) in the mineralization-related genes ( [, , , and [). - Source: PubMed
Publication date: 2026/08/06
Hemming Danielde Mattos de Araujo Bianca MarquesKirschneck ChristianScariot RafaelaPerin Camila PaivaSousa-Neto Manoel DFonseca-Souza GabrielaMattos Natanael Henrique RibeiroMeger Michelle NascimentoBaratto-Filho FlaresKüchler Erika Calvano - This study aimed to evaluate the association between single nucleotide polymorphisms (SNPs) in endochondral development-related genes and cranial base 3D phenotypes. - Source: PubMed
Publication date: 2026/07/21
Marañón-Vásquez Guido ArtemioTirre de Souza Araújo MônicaCarlos de Oliveira Ruellas AntônioMatsumoto Mírian Aiko NakaneChávez Alejandro David AvalosFigueiredo Marciode Oliveira Fernandes ThaísAntunes Lívia Azeredo AlvesLagravère Vich ManuelScariot RafaelaFlores-Mir CarlosKirschneck ChristianDos Santos Antunes LeonardoKüchler Erika Calvano - The transforming growth factor-beta (TGF-β) superfamily regulates diverse biological processes, including proliferation, differentiation, apoptosis, tissue remodeling, and reproductive signaling across metazoans. Here, we performed a genome-wide characterization of the TGF-β gene family in donkey (, ASM1607732v2) using comparative genomics and bioinformatics analyses, with horse (, EquCab3.0) as a reference to investigate evolutionary conservation and functional divergence. Genome assemblies and proteomes were retrieved from NCBI, and TGF-β genes were identified using BLASTp and HMMER searches (Pfam PF00019), followed by phylogenetic, conserved motif, synteny, Ka/Ks, mutation prediction, subcellular localization, and tissue-specific expression analyses. We identified 40 TGF-β genes in donkeys, exceeding the numbers reported in several mammals, suggesting possible lineage-specific expansion or differential gene retention within Equidae. Phylogenetic and motif analyses demonstrated strong evolutionary conservation across the two principal clades (TGF-β-like and BMP-like). Four segmental duplications were identified, with Ka/Ks ratios ranging from 0.28 to 0.43, indicating strong purifying selection on duplicated genes. Synteny analysis revealed extensive collinearity with the horse genome, supporting conserved equid genomic architecture. Comparative sequence analysis identified 160 amino acid variants, including 11 predicted deleterious mutations in key genes (, , , , and ), suggesting potential functional divergence associated with reproductive and developmental pathways. Importantly, transcriptomic validation using publicly available donkey RNA-seq tissue expression data (NCBI BioProject: PRJNA1017964) revealed distinct tissue-specific expression patterns, with reproductive tissues (ovary and uterus) displaying enriched expression of TGF-β/BMP signaling components, particularly , , , , , and , while canonical fecundity genes (GDF9 and BMP15) exhibited ovary-associated expression. This receptor-dominant signaling profile may have a coordinated TGF-β regulatory network underlying folliculogenesis, reproductive tissue remodeling, and fertility-related processes in donkeys. Subcellular localization predictions showed that most proteins (22/40) were extracellularly localized, consistent with conserved signaling functions. Together, this study provides the first integrated genomic and tissue-expression atlas of the donkey TGF-β superfamily, offering new insights into equid-specific evolutionary conservation, reproductive signaling, and functional divergence. - Source: PubMed
Publication date: 2026/07/02
Nasir TanveerTariq MuhammadTharwat MohamedSafdar MuhammadJunejo YasmeenAlshanbari Fahad A - This study aimed to evaluate the association between genetic polymorphisms in the BMP2, BMP4, RUNX2, and SMAD6 genes and the presence of severe external apical root resorption (EARR) in orthodontic patients undergoing orthognathic surgery. EARR represents a significant adverse outcome in orthodontic treatments, and genetic susceptibility may influence its occurrence. A cross-sectional study was conducted with 158 orthodontic patients treated with fixed appliances and mono or bimaxillary orthognathic surgery. Postoperative panoramic radiographs were used to assess severe EARR. Genomic DNA was extracted from buccal epithelial cells. Seven single-nucleotide polymorphisms (SNPs) in the target genes were genotyped using real-time PCR with TaqMan assays. Statistical analyses were performed with Chi-square or Fisher's exact tests. No significant associations were observed for polymorphisms in BMP2 (rs1005464, rs235768), BMP4 (rs17563), RUNX2 (rs59983488, rs1200425), or SMAD6 (rs2119261). However, a significant association was found for SMAD6 rs3934908 (p < 0.05), with the CC genotype more frequent in patients with severe EARR. No deviations from the Hardy-Weinberg equilibrium were observed. The findings suggest that the SMAD6 rs3934908 polymorphism may be associated with an increased susceptibility to severe EARR in orthodontic surgery patients. While most SNPs showed no association, these results contribute to understanding the genetic factors involved in EARR. Further studies with larger samples are needed to confirm these findings and explore gene-environment interactions. - Source: PubMed
Publication date: 2026/06/26
Schröder Ângela Graciela DeligaKuczera Milena SampaioAraujo Cristiano Miranda deFreitas Veridiana Pereira de Sá deMeger Michelle NascimentoSantos Katheleen Miranda DosScariot RafaelaKüchler Erika CalvanoBaratto-Filho Flares - To map and categorize the existing literature on the use of bone morphogenetic proteins (BMPs) in dentinogenesis and pulp tissue regeneration, identifying research trends, experimental approaches, and knowledge gaps to inform future studies and potential clinical translation. - Source: PubMed
Publication date: 2026/05/18
Portes-Zeno Ana PaulaDos Santos Alexandre GuimarãesSipert Carla RenataFonseca-Gonçalves AndréaRisso Patrícia AndradeMaia Lucianne Cople