BMP4 ELISA kit
- Known as:
- BMP4 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-BMP4-Rb
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- BMP4 ELISA kit
Related genes to: BMP4 ELISA kit
- Gene:
- BMP4 NIH gene
- Name:
- bone morphogenetic protein 4
- Previous symbol:
- BMP2B
- Synonyms:
- -
- Chromosome:
- 14q22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
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- The previous study elucidated that the C-reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis-associated anxiety-like behaviors in rats. This molecular crosstalk along the periodontal-hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several key issues remain to be further discussed regarding the establishment of the core finding linking peripheral inflammation to emotional disorders and potential translational significance. Here, this commentary analyzes the mechanisms underlying CRP entry into the brain, the choice of behavioral paradigms for emotional assessment, the possible dynamic evolution of the pathogenesis, and the translational potential of CRP, with the aim of fostering constructive academic discussion. - Source: PubMed
Publication date: 2026/06/19
Chen ZhigangLi Xing - Bone morphogenetic proteins (BMPs) are bone-derived osteokines that regulate energy metabolism and combat obesity by promoting brown adipocyte differentiation. BMP4, BMP7, BMP8B, and BMP9 are highly expressed in osteoblasts and bone matrix, from which they are released into circulation. They act as endocrine factors that induce brown adipogenesis, increase mitochondrial biogenesis, and increase thermogenesis via conserved signaling pathways (Smad, MAPK, and PGC1α). Concurrently, these BMPs maintain skeletal homeostasis and mediate crosstalk between bone and metabolic organs, including adipose tissue and the hypothalamus, thereby regulating appetite and energy balance. Preclinical studies have confirmed that BMP-based interventions can increase energy expenditure, improve insulin sensitivity, and alleviate obesity-related complications. However, clinical translation remains hindered by adverse effects, short half-lives, and obesity-induced BMP resistance. This review first elucidates the peripheral and central regulatory mechanisms of BMPs in energy metabolism, clarifies the subtype-specific metabolic effects of major BMPs, further evaluates their therapeutic potential against obesity and metabolic syndrome, and finally analyzes the core obstacles to clinical implementation and corresponding solution strategies. - Source: PubMed
Publication date: 2026/06/18
Zhang JingJiang NanWang Li-JuanCao Ting-BingXie Yang-LiLi Li - Keloid is a refractory fibroproliferative skin disorder with unclear molecular pathogenesis. Here, we delineated FOXM1's role in regulating BMP4/Smad1/5/8 signaling and keloid fibroblast (KF) behavior via integrated bioinformatics and experiments. Bioinformatics analysis of GSE145725 identified differentially expressed genes and co-expression modules. PPI network analysis and module-trait correlation pinpointed BMP4 as a central hub gene. KnockTF 2.0 prediction and luciferase assays confirmed FOXM1 directly binds BMP4 promoter sites to repress its transcription. In vitro assays showed BMP4 overexpression inhibited KF proliferation, migration, and extracellular matrix synthesis by activating Smad1/5/8 phosphorylation. FOXM1 overexpression abrogated these effects via reduced Smad1/5/8 phosphorylation, which was validated by functional rescue experiments. In summary, our findings unravel a novel FOXM1-BMP4-Smad1/5/8 regulatory circuitry in keloid pathogenesis, providing new mechanistic insights and highlighting FOXM1 as a promising therapeutic target for this recalcitrant disorder. - Source: PubMed
Publication date: 2026/05/14
Zhang LuyangLiu AnzhuXue YiJi YiWang GedunSun LetianShi Ting - The dermal papilla (DP) is essential to hair follicle development and regeneration. Isolation of human DPs still largely depends on manual microdissection and human DP cells (DPCs) lose their intrinsic properties in vitro. Establishing a culture condition that maintains the biological properties of DPCs allows for identification of cell surface markers that enable cell sorting of living human DPCs. A new DPC culture condition was developed using the combination of a WNT activator, CHIR99021, and recombinant FGF9 (CH + F9). Global gene expression profiling and bioinformatic analyses of DPCs grown under this condition were conducted to identify DPC surface markers enabling live DPC isolation. Compared to a conventional culture condition, CH + F9 increased the expression of the representative DPC biomarkers WNT5A, LEF1 and BMP4 by 3.4-, 3.8- and 60.5-fold (p < 0.01) and better maintained their expression levels after long-term serial passaging. Aggregated CH + F9-treated DPCs unevenly upregulated DP biomarkers further, suggesting that highly potent DPCs can be enriched using a marker for such cells. Bioinformatics analysis of CH + F9-treated and control DPCs identified cell marker candidates, including roundabout guidance receptor 2 (ROBO2). Importantly, ROBO2 DPCs expressing the representative DP biomarkers WNT5A, VCAN, NOG were successfully sorted from mixed cell suspensions of keratinocytes, fibroblasts and DPCs mimicking enzymatically dissociated human skin. These findings suggest that the new culture condition and cell surface marker for human DPCs established in this study provide useful tools for drug discovery and regenerative medicine to address hair loss diseases. - Source: PubMed
Hayakawa ReinaTakahashi RyoFukuyama MasahiroTsukashima AkiKimishima MomokoYamazaki YoshimiOhyama Manabu - The salmon trout or rainbow trout (Oncorhynchus mykiss) is a teleost fish are characterized by the presence of lingual teeth. The objective of this study is to investigate their development, particularly in relation to the expression of genes associated with mammalian odontogenesis. Sixty fry were reared in a freshwater aquarium at 7°C. Specimens at developmental stages ranging from D0 (hatching) to D35 were collected and subjected to histological (Masson's trichrome) and immunohistochemical analysis, including the expression of proteins associated with the Pitx2, Shh, MSX1, Pax9, Bmp4 and β-catenin genes. The developmental patterns of the lingual teeth are similar to those of the maxillary and mandibular teeth. These are not giant papillae or pseudoteeth. The initiator gene Pitx2 is expressed in the epithelium during early stages but subsequently diminishes. Bmp4, Shh and β-Cat exhibit a pattern similar to that of mammals, except for the absence of the enamel node. Surprisingly, however, we observe expression of Msx1 and Pax9 in the dental mesenchyme as well as in the epithelium, a phenomenon unknown in mammals. The second week marks an increase in the expression of these two proteins and of Shh, while Bmp4 does not appear in large quantities until 10 days. Incidentally, the mucous glands (cement glands) express Shh, Pitx2, Msx1, Pax9 and β-catenin. In conclusion, tongue teeth are 'classical' teeth; their gene expression patterns are similar to those in mammals, except that Msx1 and Pax9 are expressed in both epithelial and mesenchymal tissues in this species. - Source: PubMed
Louryan StéphaneDuterre MyriamVanmuylder Nathalie