CD40L ELISA kit
- Known as:
- CD40L Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CD40L-Fi
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CD40L ELISA kit
Related genes to: CD40L ELISA kit
- Gene:
- CD40LG NIH gene
- Name:
- CD40 ligand
- Previous symbol:
- HIGM1, IMD3, TNFSF5
- Synonyms:
- CD40L, TRAP, gp39, hCD40L, CD154
- Chromosome:
- Xq26.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
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- X-linked hyper-immunoglobulin M (XHIGM) syndrome is a rare primary immunodeficiency caused by mutations in the CD40 ligand gene , characterized by defective T-cell-dependent B-cell class-switch recombination. Patients typically present with recurrent infections in early childhood, but diagnosis is often delayed due to heterogeneous clinical manifestations and the fact that serum IgM levels may remain within the normal range in a significant proportion of patients. Here we report a case of XHIGM in an infant whose diagnostic journey began with recurrent lymphadenitis and culminated in life-threatening pneumonia (PJP). - Source: PubMed
Publication date: 2026/08/26
Guo YingHe XiaoliZhang LijunLi MengtingHe LuluLu Guoyan - Systemic inflammation is a key contributor to the pathophysiology of carotid plaque burden (CpB). Increasing evidence supports a link between periodontitis and systemic conditions, including endothelial dysfunction, and CpB. This study aimed to explore inflammatory mediators involved in cardiovascular disease that may represent shared mechanistic pathways between periodontitis and carotid plaque burden, and to determine whether non-surgical periodontal therapy modulates systemic inflammatory activity. - Source: PubMed
Publication date: 2026/08/21
Hofer Ana MariaPicos AndreiDădârlat-Pop AlexandraTomoaia RalucaRosianu HoriaTamás IlyésPopa Monica - Platelet activation is elevated in chronic obstructive pulmonary disease (COPD) and associated with self-reported respiratory symptoms. Observational studies link the antiplatelet drug aspirin to lower exacerbation rates and fewer symptoms. However, it is unknown if platelet activation predicts incident respiratory exacerbations or mortality. - Source: PubMed
Publication date: 2026/09/03
Fawzy AshrafHansel Nadia NPutcha NirupamaBalasubramanian AparnaCurtis Jeffrey LLabaki Wassim WO'Neal WandaMartinez Fernando JPaine RobertTejwani VickramWells J MichaelWoodruff PrescottBarr R GrahamPistenmaa Carrie L - We aimed to characterize associations between plasma proteins and indices of left ventricular (LV) diastolic function in two population-based studies. Eighty-six cardiovascular-related plasma proteins measured by proximity extension assay (PEA) and echocardiography were assessed in the population-based studies PIVUS (n = 1,016; all aged 70) and POEM (n = 502; all aged 50). PIVUS served as the discovery cohort, and the Benjamini-Hochberg procedure was applied to control the false-discovery rate (FDR) < 0.05. POEM was used as the replication cohort. The protein panel was related to diastolic echocardiographic parameters. A larger protein panel of 1,322 proteins was examined only in POEM. Seven of 86 proteins showed replicated associations to the E/A ratio: CD40 ligand (CD40LG), proto-oncogene tyrosine-protein kinase Src (SRC), heat shock protein beta-1 (HSPB1), epidermal growth factor (EGF), TNF superfamily member 14 (TNFSF14), vascular endothelial growth factor D (VEGFD), and endothelial cell-specific molecule 1 (ESM1). Using the larger protein panel in POEM, 81 proteins showed significant associations with the E/A ratio, and five showed significant associations with LA diameter. Pathways linked to LV diastolic filling pattern were signal transduction, metabolic, disease and immune system pathways, enhancing the understanding of LV diastolic function and offering potential for future drug development. - Source: PubMed
Publication date: 2026/09/02
Eerola EliasLind LarsMalinovschi Andrei - CD40L (CD154) is a homotrimeric member of the TNF superfamily protein expressed on activated CD4+ T cells whose interaction with CD40 is required for class-switch recombination, somatic hypermutation, and B cell terminal differentiation. Loss-of-function mutations in gene CD40LG cause X-linked hyper-IgM syndrome type 1 (HIGM1), characterized by recurrent infections, lack of IgG, IgA and IgE, and near-normal or elevated IgM. - Source: PubMed
Publication date: 2026/08/17
Velásquez-Ortiz María GuadalupeJardón-Valadez EduardoReyes-Huerta Raúl FernandoCatalán-Dibene JovaniBerrón-Ruiz LauraLópez-Herrera GabrielaMeza-Sánchez David EduardoMaravillas-Montero José Luis