AQP4 ELISA kit
- Known as:
- AQP4 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-AQP4-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- AQP4 ELISA kit
Related genes to: AQP4 ELISA kit
- Gene:
- AQP4 NIH gene
- Name:
- aquaporin 4
- Previous symbol:
- -
- Synonyms:
- MIWC
- Chromosome:
- 18q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-25
- Date modifiied:
- 2016-10-05
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- Neuromyelitis optica spectrum disorder (NMOSD) is a rare disease that is often misdiagnosed and that can have ethnic variations. No prior study of this condition in a Kashmiri cohort has been reported, which motivated this study. - Source: PubMed
Publication date: 2026/04/29
Mir Toufeeq AhmadHassan TanveerAhmad Sheikh HilalKawoosa Atif RasoolSanaie Bashir Ahmad - Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) deficiency is a rare genetic disorder characterized by immune dysregulation. The immune checkpoint molecule cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) fails to perform proper membrane trafficking in the absence of LRBA. In addition to immune cells, LRBA localizes to intracellular vesicles in various epithelial cells; however, its physiological roles have not been accurately deciphered. It was observed in this study that LRBA facilitates water and sodium transport by promoting vesicular trafficking of aquaporin-2 (AQP2) and AQP4 in renal collecting duct cells and that of sterile 20/SPS1-related proline/alanine-rich kinase (SPAK) in distal convoluted tubule cells. Consequently, knockout mice exhibited vasopressin-resistant polyuria and hypotension under sodium-restricted conditions. This registry study revealed a polyuric phenotype in a subset of patients with LRBA deficiency, characterized by inappropriately low urine specific gravity despite the presence of chronic diarrhea. Notably, desmopressin treatment ameliorated impaired urinary concentration in a mouse model of human LRBA deficiency. LRBA functions as a central coordinator of fluid and sodium homeostasis by organizing segment-specific vesicular trafficking systems in renal epithelial cells. - Source: PubMed
Publication date: 2026/04/28
Nagaoka KanakoAndo FumiakiFujiki TamamiAbolhassani HassanHara YuYanagawa HidekiSuzuki SoichiroSakamaki YurikoOikawa DaisukeKikuchi HiroakiMandai ShintaroMori YutaroMori TakayasuSusa KoichiroSohara EiseiHoshino AkihiroIto TsuyoshiArakawa YukiSasahara YojiYasuda ShinsukeAbe YoichiroYasui MasatoTokunaga FuminoriKanegane HirokazuUchida Shinichi - Autoimmune myelitis represents a heterogeneous group of disorders whose classification has evolved substantially over the past decade. Advances in antibody diagnostics and the widespread use of immune checkpoint inhibitors (ICIs) in oncology have reshaped current concepts, revealing mechanistic and clinical overlaps between antibody-mediated, paraneoplastic, and treatment-induced myelopathies. - Source: PubMed
Publication date: 2026/04/29
Collongues Nicolas - Repeated stress triggers anxiety accompanied by a deregulation of cortical glucocorticoid receptors, which is relieved by blocking adenosine A receptors (AR). AR also controls the glymphatic system and the polarization of its key driver aquaporin-4 (AQP4). Since the glymphatic system is altered upon repeated stress, we now tested if AR blockade could alleviate AQP4 polarization in rats subject to repeated restraint stress (RRS). As expected, RRS enhanced anxiety in the elevated plus maze, decreased self-care behavior in the splash test, and decreased cortical glucocorticoid receptors levels; these alterations were prevented by daily treatment with the selective AR antagonist KW-6002 (3 mg/kg/day). KW-6002 treatment also prevented the RRS-induced decrease of AQP4 density in gliosomes, corresponding to astrocytic membrane endfeet, the perivascular AQP4 polarization in astrocytes, and both perivascular and cellular AQP4 coverage. These findings show that AR controls AQP4 polarization upon restraint stress and prompt considering that AR might control the impact of repeated stress on brain dysfunction through a control of the glymphatic system. - Source: PubMed
Dias LilianaFerreira Samira GNabais Ana MargaridaSilva JoanaCunha Rodrigo AAgostinho Paula - Cannabidiol (CBD) has recently gained significant public acceptance as a safe therapeutic, contributing to increased use during pregnancy. However, little is known about how maternal CBD exposure impacts fetal brain development. Here, we established a preclinical CBD perinatal exposure (CBD-PCE) model to examine the impacts of CBD on astrocyte morphology in the medial prefrontal cortex (mPFC), a brain region critical for working memory and affective behaviors. Astrocytes play critical roles in maintaining ionic/metabolic homeostasis, neurotransmission, and neurovascular coupling in the CNS. They exhibit highly ramified processes with endfeet surrounding synapses, forming tripartite synapses. We quantitatively assessed the impact of CBD-PCE on astrocyte morphology and the composition of tripartite synapses in mPFC using high-resolution three-dimensional (3D) imaging. Our morphometric analyses revealed that CBD-PCE reduced astrocyte density and increased the number of major branches and whole-cell volume in the mPFC of male, but not female, progenies. Using high-magnification 3D analysis, we found that mPFC astrocytes after CBD-PCE exhibited increased neuropil infiltration volume and reduced surface-to-volume ratios in males but not in females. Moreover, the levels of aquaporin-4 (AQP4) and Kir4.1 inwardly rectifying potassium channel, two key components in regulating ionic homeostasis, are elevated on the membranes of male CBD-PCE astrocytes. We also analyzed mPFC tripartite synapses and observed significant increases in thalamocortical tripartite synapse density in both sexes, whereas intracortical excitatory synapses were reduced only in females. Collectively, these findings demonstrate that CBD-PCE induces sex-specific changes in astrocyte morphology and in the composition of tripartite synapses in the mPFC of the progeny's brains. - Source: PubMed
Publication date: 2026/04/17
Dias de Abreu Gabriel HenriqueWilson JeremyRitzmann VitorMoosbrugger OscarJohnson Clare TMackie KenBradshaw HeatherHuang Jui-YenLu Hui-Chen