AQP5 ELISA kit
- Known as:
- AQP5 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-AQP5-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- AQP5 ELISA kit
Related genes to: AQP5 ELISA kit
- Gene:
- AQP5 NIH gene
- Name:
- aquaporin 5
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-25
- Date modifiied:
- 2016-10-05
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- Hydroxychloroquine (HCQ), a commonly used drug for Sjögren's syndrome (SS), is ineffective, highlighting the need for better treatments for salivary gland damage in SS. The study evaluated the effects of Polygonatum sibiricum (HJ) on SS using non-obese diabetic (NOD) mice treated with HJ, HCQ, or both for six weeks. Body weight, saliva levels, and submandibular gland histology were assessed. Various techniques were used to analyze apoptosis and oxidative stress. Network pharmacology identified therapeutic targets, and lentivirus technology was used to suppress CHRM3 gene expression to understand HJ's mechanisms against SS. HJ treatment significantly mitigates salivary gland damage, resulting in increased body weight, reduced water intake, and improved saliva flow rates. Histological evaluations revealed HJ reduced lymphocytic infiltration, restored glandular architecture, and alleviated oxidative stress. In addition, the study has the following key mechanistic finding: HJ upregulated the expression of the target proteins CHRM3 and AQP5 in submandibular glands. Additionally, HJ can significantly enhance the expression of CHRM3 and AQP5 in human salivary gland (HSG) cells after silencing CHRM3. This study revealed that HJ may act as a novel SS treatment by activating the CHRM3/AQP5 axis, promoting water channel transport, alleviating salivary gland damage, and enhancing saliva secretion. Moreover, the combination of HJ and HCQ could significantly improve the therapeutic benefit. These findings provide a new therapeutic strategy for SS. - Source: PubMed
Publication date: 2026/04/29
Wu FangpingWu XinjieDai LeweiPeng JiananLi RuoxuanZhou YangqingGu MancangLu WenwenPan Bo - Aquaporins (AQPs) are transmembrane channel proteins that transport water and small solutes. Their dysregulation in cancer reveals functions beyond maintaining osmotic balance. This review summarizes that AQPs drive tumor progression through three core mechanisms: metabolic reprogramming, enhanced motility, and remodeling of the immune microenvironment. Specifically, AQP3, AQP7, and AQP9 serve as metabolic hubs for glycerol, while AQP3 and AQP8 help maintain redox homeostasis. AQP1 and AQP4 facilitate cell migration via hydrodynamic mechanisms, and AQP5 promotes invasion through signaling pathways such as Ras/NF-κB. In immune regulation, AQP9 and AQP3 modulate immune cell function by transporting metabolites, and AQP1 influences angiogenesis. Other isoforms, including AQP0, AQP2, AQP6, AQP10, and AQP11, also play roles in malignancy. Collectively, AQPs form a multifunctional network linking tumor metabolism, physical properties, and immunity, offering insights for novel diagnostic and therapeutic strategies. However, tissue-specific functions, complex regulatory mechanisms, and challenges in developing targeted therapies remain significant hurdles in translational medicine. - Source: PubMed
Publication date: 2026/03/26
Qu KexinWang RuiBi YingweiLiu YuxinYi BolinWang Jianbo - Asthma is a widespread chronic inflammatory condition of the airways, often triggered by allergens such as ovalbumin. This study aimed to evaluate the potential anti-asthmatic effects of a synthetic isoxazolone derivative, (Z)-4-(4-hydroxy-3-methoxybenzylidene)-3-methylisoxazole-5(4H)-one (HMM), in a mouse model of allergic asthma. Molecular docking was carried out to explore the HMM interaction with asthma-associated proteins, providing insights into its potential therapeutic targets. Thirty-six albino mice were randomly divided into six groups: negative control, positive control, standard drug group (methylprednisolone, 15 mg/kg), and three groups receiving HMM at doses of 3.2, 6.3, and 12.6 mg/kg. Mice were sensitized with ovalbumin on days 0 and 14, followed by intranasal exposure from days 15 to 21 to induce allergic airway inflammation. Blood and bronchoalveolar lavage fluid (BALF) were collected to measure total and differential leukocyte counts. Cytokine expression (IL-4, IL-5) and aquaporins (AQP-1, AQP-5) were quantified via real-time PCR. HMM-treated groups showed reduced inflammation, lowered Th2 cytokine levels, and improved lung water transport markers. Computational studies supported these findings, revealing strong binding affinities between HMM and TNF-α (- 6.07 kcal/mol), AKT1 (- 6.32 kcal/mol), and COX-2 (- 5.87 kcal/mol), forming stable hydrogen-bond interactions with key active-site residues. These results suggest HMM holds promise as a potential anti-asthmatic agent. - Source: PubMed
Publication date: 2026/04/13
Shaikh Abdul RashidMobashar AishaSharif AliAkhtar BushraAlghamdi Ohoud AAlyami Esmael MElossaily Gehan MAlmohammed Omar AMetouekel AmiraBourhia Mohammed - Siraitiae fructus (SF) is a traditional medicinal and edible herb, commonly used for heat-dissipation, lung-moistening, and constipation relief. Previous studies have confirmed that siraitiae fructus total saponins (SFTS) exhibit the same pharmacological activity as SF. This study aims to investigate the mechanism of the anti-constipation effects of SFTS and its representative ingredient (mogroside V, MV). A loperamide hydrochloride induced functional constipation rat model was used, along with biochemical analysis, histopathological analysis, 16S rRNA sequencing, short-chain fatty acids (SCFAs) analysis, and western blotting. SFTS was found to restore fecal water content, fecal morphology, gut microbiota and short-chain fatty acids. It also inhibits the TLR4/MyD88/NF-κB pathway and the AQP3 expression, while upregulating the expression of c-Kit and occludin. Additionally, SFTS promoted the secretion of MTL and GAS, decrease the release of VIP, and effectively alleviated constipation. Furthermore, SFTS suppressed the TLR4/MyD88/NF-κB and PPAR-γ/RXR-α pathway, and reduce the AQP5 expression, thereby mitigating pulmonary dysfunction induced by constipation. As expected, SFTS demonstrated broader efficacy than MV. These findings highlighted the role of SFTS and MV as edible bioactives in alleviating constipation and associated extra-intestinal inflammation, supporting their potential as functional food for gastrointestinal and systemic health. - Source: PubMed
Pu ZongjinChen XiaonanMa YuhangLiu YixinPeng YingLi Xiaobo - To characterize the proliferative and immunophenotypic profiles of salivary gland mucoepidermoid carcinoma (MEC) and to explore their associations with clinicopathologic features, tumour microenvironment (TME) characteristics, Pan-TRK expression, and disease prognosis. - Source: PubMed
Publication date: 2026/03/31
Tran Vy Ngoc ThuyRuangritchankul KomkritNikitakis Nikolaos GFerreira João NChaisuparat Risa