CASP3 ELISA kit
- Known as:
- CASP3 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CASP3-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CASP3 ELISA kit
Related genes to: CASP3 ELISA kit
- Gene:
- CASP3 NIH gene
- Name:
- caspase 3
- Previous symbol:
- -
- Synonyms:
- CPP32, CPP32B, Yama, apopain
- Chromosome:
- 4q35.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-22
- Date modifiied:
- 2016-10-05
Related products to: CASP3 ELISA kit
Human ELC ELISA KIT 96 TEST
OxiSelect In Vitro ROS/RNS Assay Kit (Green Fluorescence), Trial Size
OxiSelect Methylglyoxal (MG) Competitive ELISA Kit
OxiSelect Methylglyoxal (MG) Competitive ELISA Kit
OxiSelect TBARS Assay Kit (MDA Quantitation), Trial Size
OxiSelect Total Antioxidant Capacity (TAC) Assay Kit, Trial Size
OxiSelect™ In Vitro ROS RNS Assay Kit (Green Fluorescence), Trial Size(1-3)-beta-D-glucan Sandwich ELISA, Double Antibody(1-Kit )11,12-EET DHET Immunoassay Kit(1-Kit )11,12-EET_DHET Immunoassay Kit(1-Kit) 11,12-DHET Immunoassay Kit(1-Kit) 14,15-DHET Human Urine ELISA Kit(1-Kit) 14,15-DHET Hypertension ELISA Kit(1-Kit) 14,15-DHET sEH activity ELISA Kit(1-Kit) 14,15-EET DHET Hypertension ELISA Kit Related articles to: CASP3 ELISA kit
- To compare the characteristic differences between apoptotic extracellular vesicle (ApoEV) and non-apoptotic cell-derived extracellular vesicle (NCEV) from bone marrow mesenchymal stem cells (BMSCs), and to explore their therapeutic effects on inflammatory macrophages and cisplatin-induced acute kidney injury (AKI) in mice. - Source: PubMed
Lin ZehuanChen JiamanLin TaoLiu ShuyunLiu Jingping - Although platinum-based therapies are of central importance in oncology, their clinical benefits are often limited by systemic toxicity and the emergence of drug resistance. This study, a mechanistic continuation of our previous research on the cytotoxicity of organometallic Ru(II) complexes, presents a comprehensive in vitro investigation of the antineoplastic pathways of monometallic (Ru1) and bimetallic Ru(II) arene complexes (Ru2, Ru3) carrying diamine ligands. We evaluated their efficacy in prostate (PC-3, DU145) and colorectal (HT-29) cancer models, as well as in non-cancerous Vero cells. Morphological assessments and long-term wound healing tests revealed that the bimetallic complex (Ru3) significantly suppressed cellular motility and caused total cell death over a 7-day period. Immunocytochemical analysis of γ-H2AX foci confirmed that the complexes caused potent DNA double-strand breaks, and Ru3 demonstrated superior genotoxic activity in all cell lines. Mechanistic elucidation via flow cytometry and immunoblotting revealed that these complexes trigger a p53-dependent mitochondrial apoptotic pathway characterized by depolarization of the mitochondrial membrane potential, significant release of Cytochrome C, followed by Caspase-3 and PARP activation. Furthermore, treatment caused a remarkable reduction in anti-apoptotic Bcl-2 and Bcl-xL proteins. In particular, Ru1 exhibited unique antioxidant-like properties by reducing intracellular ROS and 8-OHdG levels in specific cell lines, suggesting a novel protective role in oxidative metabolism as well as its anticarcinogenic potential. Collectively, these results provide a potent molecular map for the activity of these Ru(II) diamine complexes and highlight Ru3 as a strong candidate for the development of next-generation, targeted anticancer therapies. - Source: PubMed
Publication date: 2026/08/22
Kavukcu Serdar BatıkanVatansever Hafize SedaÖzdal-Kurt FeyzanKorkmaz MehmetErbaykent BurcuEnsarioğlu Hilal KabadayıTürkmen Hayati - Postoperative rejection following liver transplantation is closely associated with dysregulated macrophage M1/M2 polarization. Arctiin (ARC) exhibits anti-inflammatory activity; however, its role and underlying mechanisms in transplant rejection remain unclear. - Source: PubMed
Publication date: 2026/08/25
Wei DelingXia XiafeiJin ZongruiLiu JunlinBian CongwenLi ChenxuanZhu HaiYuan BoZhang ZhengLuo JiajiaoShi JiyuanZeng ZhongHuang HanfeiLin Jie - Bisphenol S (BPS) is an emerging environmental contaminant that can disrupt oxidative and immune homeostasis in aquatic organisms, whereas myo-inositol (MI) is a water-soluble nutrient involved in growth and cellular signaling. This study evaluated growth, hepatopancreatic biochemical indices, and stress-related gene transcription in crayfish fed 0 or 1000 mg/kg supplemental MI and chronically exposed to 0-10 µg/L BPS for 6 weeks. Compared with the control group, the BPS group had significantly lower weight gain rate (WGR), specific growth rate (SGR), molting frequency, antioxidant enzyme activities (SOD, CAT, and POD), and immune enzyme activities (ACP, AKP, PO, and LZM), together with higher MDA content (P < 0.05). Compared with the BPS group, the MI + BPS group had significantly higher WGR, SGR, molting frequency, SOD, POD, ACP, and PO activities (P < 0.05). The MI + BPS group also showed higher nrf2 and hmc mRNA levels and lower keap1, bip, ire1, casp3, cytc, jnk, il-6, tnf-α, and nf-κb mRNA levels than the BPS group (P < 0.05). WGR, SGR, molting frequency, and hmc mRNA abundance in the MI + BPS group did not differ significantly from the control group (P > 0.05), the remaining endpoints showed indicator-specific responses. These findings indicate that dietary MI supplementation was associated with improved growth and selected antioxidant and immune indices, as well as altered transcription of genes related to oxidative, endoplasmic-reticulum-stress, inflammatory, and apoptosis-associated responses under BPS exposure. Pathway activation, tissue injury, and apoptosis were not directly assessed. - Source: PubMed
Publication date: 2026/08/25
Pu ChangchangLiu YuanyiWang JunhuiWang BingkeWang AiminZhang Chunnuan - To elucidate the cytoprotective capacity of paeonol (PAE) against hypoxia/reoxygenation (H/R) injury in H9C2 cardiomyoblasts and to clarify its regulatory effects on the hypoxia-inducible factor 1-alpha (HIF-1α) and B-cell lymphoma-2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) signaling axis governing autophagy and apoptosis. - Source: PubMed
Chengguo ZhaoMeifang YinMenghan ZhouShuzhi Qin