ADCYAP1 ELISA kit
- Known as:
- ADCYAP1 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ADCYAP1-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ADCYAP1 ELISA kit
Related genes to: ADCYAP1 ELISA kit
- Gene:
- ADCYAP1 NIH gene
- Name:
- adenylate cyclase activating polypeptide 1
- Previous symbol:
- -
- Synonyms:
- PACAP
- Chromosome:
- 18p11.32
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-02
- Date modifiied:
- 2016-10-05
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- Menopause is characterized by the cessation of ovarian hormone production. During postmenopause, cisgender women face increased risks of obesity, cognitive decline, and mood disorder. Mood disorders are associated with exposure to chronic stress. We investigated the combined effects of a high-fat diet (HFD) and chronic stress exposure in a mouse model of menopause using 4-vinylcyclohexene diepoxide (VCD), a selective ovotoxicant that gradually depletes ovarian follicles and hormones. Starting at 6 months, 82 female WT C57BL/6 J mice received sesame oil or VCD (130 mg/kg i.p.) 5 days per week for 3 weeks. One month after injection, mice were fed either low-fat diet (LFD) or HFD for 8 weeks followed by 6 weeks of chronic variable mild stress (CVMS). Post-CVMS, mice were either processed for gene expression of the anterodorsal bed nucleus of the stria terminalis (adBNST) or behavior tests to assess cognitive and anxiety-related behaviors. Plasma samples were collected to analyze metabolic hormones and corticosterone levels. VCD-treated HFD-fed mice had higher fat and body mass, and elevated fasting glucose levels compared to controls and more pronounced avoidance behaviors and cognitive impairments. VCD-treated LFD-fed mice exhibited less exploration of novel objects and open spaces compared to sesame oil and HFD counterparts. VCD elevated corticosterone levels on LFD and increased BNST Adcyap1 (PACAP) gene expression on HFD. These findings highlight cognitive repercussions of estrogen deficiency and suggest a potential protective effect of a HFD against some of the adverse outcomes associated with menopause. Our study emphasizes the importance of considering dietary and hormonal interactions in the development of therapeutic strategies. - Source: PubMed
Publication date: 2026/05/14
Knox NadjaYasrebi AliCaramico DanielDenney Katherine AWiersielis KimberlySamuels Benjamin ARoepke Troy A - Bladder painsyndrome (BPS) is a disabling condition diagnosed clinically, characterised by marked heterogeneity in cystoscopic phenotype and treatment response. Molecular mechanisms remain incompletely defined, and no validated biomarkers currently support diagnosis or phenotypic stratification. The objective was to synthesise molecular evidence underpinning BPS and evaluate biomarker candidates relevant to phenotype-informed diagnostics. - Source: PubMed
Publication date: 2026/05/05
Kaltsa AnastasiaShendy Maged Morad FouadKyriazis Grigorios - Yueju pill (YJ), a classical Chinese medicine formula first documented in 'Danxixinfa by Zhu Danxi for treating "six stagnations" (Liu Yu: qi, blood, phlegm, fire, dampness, and food), has been clinically prescribed for mood disorders characterized by qi stagnation and depression for centuries. Despite its historical application for relieving emotional constraint (Yujie) and treating depressive disorders, the rapid antidepressant mechanism and molecular targets of YJ remain incompletely elucidated. - Source: PubMed
Publication date: 2026/04/23
Xing ShanPeng YuhanWang YanqinWu ChangyuHan MingzhiXie HuijunChen GangZhang Hailou - Yueju pill (YJ), a classical Traditional Chinese Medicine formula for "six stagnations", has long been used for mood disorders. We have previously demonstrated that YJ exerts rapid-onset antidepressant effects. However, the long-lasting antidepressant effects and its underlying neurobiological mechanisms remain elusive. - Source: PubMed
Publication date: 2026/04/13
Xing ShanPeng YuhanWong Nga-LeeWu ChangyuFu ZhenzhenTan JingwenXie HuijunChen GangZhang Hailou - G protein-coupled receptors (GPCRs) are key regulators of intercellular communication. One sub-family, named class B1 GPCRs, including the pituitary adenylate cyclase-activating polypeptide 1 receptor (PAC1R), is important for metabolic, cardiovascular, and endocrine functions. Currently, there is a wealth of structural data describing the active G protein-coupled state of class B1 GPCRs, and more limited information on inactive or intermediate states. Although these structures provide insight into conformational differences between different activation states, the receptor dynamics underpinning them remain largely unknown. Here, we employed hydrogen deuterium exchange mass spectrometry (HDX-MS) to investigate the dynamics of PAC1R across three distinct states: inactive (apo), intermediate (peptide agonist-bound), and fully active (peptide agonist and G protein-bound). This revealed dynamics of different states along the PAC1R activation pathway and deepens the understanding of class B1 GPCR dynamics and molecular mechanisms of receptor activation. - Source: PubMed
Publication date: 2026/02/24
Nettleton Theodore JFairweather CameronPiper Sarah JIshii KentaGarama Daniel JSexton Patrick MJosephs Tracy MWootten Denise