ADCYAP1 ELISA kit
- Known as:
- ADCYAP1 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-ADCYAP1-Mu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- ADCYAP1 ELISA kit
Related genes to: ADCYAP1 ELISA kit
- Gene:
- ADCYAP1 NIH gene
- Name:
- adenylate cyclase activating polypeptide 1
- Previous symbol:
- -
- Synonyms:
- PACAP
- Chromosome:
- 18p11.32
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-02
- Date modifiied:
- 2016-10-05
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- Yueju pill (YJ), a classical Chinese medicine formula first documented in 'Danxixinfa by Zhu Danxi for treating "six stagnations" (Liu Yu: qi, blood, phlegm, fire, dampness, and food), has been clinically prescribed for mood disorders characterized by qi stagnation and depression for centuries. Despite its historical application for relieving emotional constraint (Yujie) and treating depressive disorders, the rapid antidepressant mechanism and molecular targets of YJ remain incompletely elucidated. - Source: PubMed
Publication date: 2026/04/23
Xing ShanPeng YuhanWang YanqinWu ChangyuHan MingzhiXie HuijunChen GangZhang Hailou - Yueju pill (YJ), a classical Traditional Chinese Medicine formula for "six stagnations", has long been used for mood disorders. We have previously demonstrated that YJ exerts rapid-onset antidepressant effects. However, the long-lasting antidepressant effects and its underlying neurobiological mechanisms remain elusive. - Source: PubMed
Publication date: 2026/04/13
Xing ShanPeng YuhanWong Nga-LeeWu ChangyuFu ZhenzhenTan JingwenXie HuijunChen GangZhang Hailou - Alzheimer's disease (AD) is a progressive neurodegenerative age-related disorder characterized by widespread transcriptional deregulation across multiple brain regions. Among the molecular players involved, the transcription factors (TFs) can regulate the expression of AD-related peptides (β-amyloid and tau). We aim to unveil reconstructed TF-centered networks and their dynamics across multiple brain regions. In this study, we conducted an exhaustive differential gene expression analysis, reconstructed TF-TF-centered regulatory networks, and performed master-regulation analyses across multiple regions. We used bulk RNA-seq data from 2,229 post-mortem samples from the ROSMAP, MAYO, and MSBB cohorts. To place these regulatory programs in a disease-relevant context, we integrated protein-protein interaction (PPI) data, experimental TF-target data, and AD-associated genetic risk loci as a translational layer. We assessed TF-centered regulons for 1,605 TFs and identified 354 master-regulators (MR-TFs) across multiple brain regions, including the parahippocampal gyrus, temporal cortex, and cerebellum, which exhibited the highest numbers of regulons. Overall, regulons fell within a moderate size range (median 55 targets), rather than into extensive large networks. Novel MR-TFs, including ADCYAP1, TEAD2, BCL6, MAFF, NFKBIA, were consistently identified as MR-TFs across tissues in AD. Furthermore, GUCY1B1, RBFOX2, and MEF2C were found conserved in the parahippocampal gyrus, inferior frontal gyrus, and posterior cingulate cortex. Additionally, our work identified the well-known AD-related genes BIN1, EGFR, and SPI1 as MR-TFs, reinforcing their functional roles as susceptibility risk markers in AD. This work established an MR-TF-centered integrated regulatory network map of AD, revealing MR-TFs as factors that orchestrate gene deregulation in a region- and cell-context-dependent approach, and providing a robust foundation for mechanistic and translational investigations in neurodegeneration. - Source: PubMed
Publication date: 2026/02/23
Belém-Souza Marcella VitóriaBarra-Matos Gustavode Araújo Gilderlanio Santana - Precise, dynamic control of metabolic fuel usage in response to environmental challenges such as altered food availability or temperature change is essential for animal survival. In mammals, metabolic flexibility-the capacity to shift cellular metabolism between carbohydrate and fatty acid oxidation-is understood to be largely regulated by circulating hormones such as insulin and glucagon. However, the role of the central nervous system in coordinating fuel selection and tissue metabolic tuning remains underexplored. Here, we investigated the mechanisms that mediate metabolic reprogramming following the acute activation of torpor-associated glutamatergic Adcyap1+ torpor-regulating neurons in the anteroventral preoptic area (avPOA). The activation of these neurons rapidly shifts whole-body fuel use from glucose to fatty acids, irrespective of fuel/food availability. This shift is associated with reduced glucose utilization stemming from the transient induction of selective insulin resistance in skeletal muscle. We find that this reduction in skeletal muscle glucose metabolism does not require direct muscle innervation but is rather mediated in part via corticosterone. In contrast to their activation, avPOA neuronal silencing results in improved glucose tolerance, demonstrating powerful bidirectional control of tissue-specific glucose metabolism, whole-body glucose levels, and fuel usage. Together, our findings uncover a novel POA -skeletal muscle pathway that dynamically controls glucose utilization and metabolic flexibility. - Source: PubMed
Publication date: 2026/02/14
Roessler Julian MAlkire MatthewNigrin NathanWang HaoruiReid Christopher MCortopassi Marissa DWaite MilleniaLinnehan BrookeGriffith Eric CMadigan MollieKunchok TenzinBanks Alexander SSchulte FabianKim BukyungKim Bo-YeonKim Jason KHrvatin Siniša - Sexual size dimorphism (SSD) refers to the phenomenon where males and females of the same species exhibit differences in overall or partial body size, and it is widespread among mammals, birds, reptiles, and fish. Notably, this dimorphism is significantly influenced by the sexually dimorphic secretion of growth hormone (), a key pituitary-derived growth regulator. Commonly, the secretion of is positively regulated by glucagon family members such as growth hormone-releasing hormone () and adenylate cyclase-activating polypeptide 1 (). To explore the stimulators for pituitary hormones (especially ) in the teleost, we performed genome-wide identification and functional characterization of the glucagon family on Chinese tongue sole () that exhibits typical female-biased sexual size dimorphism. Four members of /vasoactive intestinal polypeptide()/ family and ten members of their receptor family were identified. Expression pattern analysis revealed high expression of adenylate cyclase-activating polypeptide 1b () and its receptors in the brain. Moreover, two alternative splice variants for the gene were discovered, resulting from the skipping of exon 4. Following the acquisition of the two eukaryotic recombinant protein splice variants (ADCYAP1b_tv1 and ADCYAP_tv2) from HEK 293T cells, incubation experiments were conducted using pituitary cell line. The results demonstrated that both variants promoted the expression of , pro-opiomelanocortin (), and corticoliberin (), but ADCYAP1b_tv1 had a significantly stronger effect and uniquely stimulated prolactin () and somatolactin (). This study demonstrates a functional divergence between the two ADCYAP1b splice variants in teleosts, with ADCYAP1b_tv1 acting as a more potent and versatile pituitary hormone stimulator. Further research on their receptor-binding affinity and downstream signaling pathways would be valuable for exploring the mechanism underlying sexual size dimorphism. - Source: PubMed
Publication date: 2026/01/26
Zhang QianLi XihongZhang YueLi WenjieCai ZhenyuXu WentengChen SonglinWang Na