APOA1 ELISA kit
- Known as:
- APOA1 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-APOA1-p
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- APOA1 ELISA kit
Related genes to: APOA1 ELISA kit
- Gene:
- APOA1 NIH gene
- Name:
- apolipoprotein A1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
- Gene:
- NAXE NIH gene
- Name:
- NAD(P)HX epimerase
- Previous symbol:
- APOA1BP
- Synonyms:
- AIBP, MGC119143, MGC119144, MGC119145, YJEFN1
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-01
- Date modifiied:
- 2016-10-05
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- Accumulating evidence indicates that the APOA1 binding protein (AIBP)-a secreted protein-plays a profound role in lipid metabolism. Interestingly, AIBP also functions as an NAD(P)H-hydrate epimerase to catalyze the interconversion of NAD(P)H hydrate [NAD(P)HX] epimers and is renamed as NAXE. Thus, we call it NAXE hereafter. We investigated its role in NAD(P)H-involved metabolism in murine cardiomyocytes, focusing on the metabolism of hexose, lipids, and amino acids as well as mitochondrial redox function. Unbiased metabolite profiling of cardiac tissue shows that NAXE knockout markedly upregulates the ketone body 3-hydroxybutyric acid (3-HB) and increases or trends increasing lipid-associated metabolites cholesterol, α-linolenic acid and deoxycholic acid. Paralleling greater ketone levels, ChemRICH analysis of the NAXE-regulated metabolites shows reduced abundance of hexose despite similar glucose levels in control and NAXE-deficient blood. NAXE knockout reduces cardiac lactic acid but has no effect on the content of other NAD(P)H-regulated metabolites, including those associated with glucose metabolism, the pentose phosphate pathway, or Krebs cycle flux. Although NAXE is present in mitochondria, it has no apparent effect on mitochondrial oxidative phosphorylation. Instead, we detected more metabolites that can potentially improve cardiac function (3-HB, adenosine, and α-linolenic acid) in the heart; these mice also perform better in aerobic exercise. Our data reveal a new role of NAXE in cardiac ketone and lipid metabolism. - Source: PubMed
Publication date: 2022/11/17
Kim Jun-DaeZhou TengZhang AijunLi ShuminGupte Anisha AHamilton Dale JFang Longhou - The goal of this manuscript is to summarize the current understanding of the secreted APOA1 binding protein (AIBP), encoded by NAXE, in angiogenesis, hematopoiesis, and inflammation. The studies on AIBP illustrate a critical connection between lipid metabolism and the aforementioned endothelial and immune cell biology. - Source: PubMed
Publication date: 2020/11/24
Qiu XuetingLuo JingminFang Longhou