CAV1 ELISA kit
- Known as:
- CAV1 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- DL-CAV1-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- WDSTD
- Gene target:
- CAV1 ELISA kit
Related genes to: CAV1 ELISA kit
- Gene:
- CAV1 NIH gene
- Name:
- caveolin 1
- Previous symbol:
- CAV
- Synonyms:
- -
- Chromosome:
- 7q31.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-02
- Date modifiied:
- 2016-10-05
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- Functional dyspepsia (FD) is a disorder of gut-brain interaction involving heterogeneous motor, sensory, immune, and oxidative stress-related mechanisms. Simotang oral liquid (SMT), a traditional Chinese medicine formulation used for dyspeptic and gastrointestinal motility-related symptoms, has not been evaluated with an integrated clinical, functional, and molecular framework. This single-arm prospective pre-post study assessed gastric emptying by the 13C-octanoic acid breath test, gastric electrical activity by electrogastrography, postprandial tolerance by nutrient drink testing, symptom scores, serum biomarkers, and gastric antral tissue markers in patients with FD. FD-like mice were used for charcoal meal transit, smooth muscle strip tension, calcium channel blockade, and mucosal RNA sequencing. Public transcriptomic data from GSE169304 were analyzed to characterize FD-associated duodenal mucosal molecular features. SMT treatment was associated with reduced gastric emptying half-time, improved 3-cpm stability, lower gastric dysrhythmia, reduced Nepean Dyspepsia Index and Gastroparesis Cardinal Symptom Index scores, increased motilin and gastrin levels, lower malondialdehyde, higher superoxide dismutase activity, and lower tumor necrosis factor alpha and interleukin-6 levels. Paired gastric antral biopsy analyses showed increased α-smooth muscle actin and higher phosphorylation ratios of myosin light chain kinase and myosin light chain after SMT treatment. In mice, SMT increased intestinal transit, acetylcholine-induced smooth muscle tension, Cav1.2 abundance, calmodulin fluorescence, and p-MLCK/p-MLC signaling, while nifedipine reduced the SMT-associated phosphorylation changes. Transcriptomic analyses showed enrichment of smooth muscle contraction, calcium signaling, oxidative stress response, and Nrf2-related antioxidant pathways, while protein analyses showed reduced canonical NF-κB activation markers. The data are consistent with Ca-dependent smooth muscle contraction as the central motor pathway associated with SMT- related functional improvement in FD, with Nrf2/NF-κB modulation as a microenvironmental regulatory component. - Source: PubMed
Mao GuoHe ChunxiangLiu JiaqinWu DahuaZeng PuhuaMao Ye - The cardiac calcium channel Ca1.2 is essential for embryonic development, cardiac excitation-contraction coupling, and the "Fight or Flight" response. Regulation of Ca1.2 by protein kinase A (PKA) phosphorylation is critical to this process, though the underlying mechanism remains contentious. We previously identified serine 1458 (S1458) in the proximal C-terminus of the human Ca1.2 as essential for PKA-mediated regulation in vitro. To investigate its functional role in vivo, we generated three mouse models targeting S1487, the mouse equivalent of human S1458. Comprehensive phenotyping and assessment of responses to β-adrenergic receptor stimulation were conducted in vivo, ex vivo, and in vitro. We demonstrate for the first time that a seven amino acid (7aa) region containing S1487 is crucial for proper channel folding, as homozygous mutant mice exhibited embryonic lethality. We confirm that phosphorylation at S1487 is necessary for altered Ca1.2 function required for the "Fight or Flight" response, clarifying the functional significance of this region. - Source: PubMed
Publication date: 2026/09/14
Jenkins CatherineCserne Szappanos HenriettaDyrda AgnieszkaEr Teagan Svan Petegem FilipHool Livia C - Atrial fibrillation (AF) is the most prevalent clinical arrhythmia, yet current antiarrhythmic pharmacotherapies have limited efficacy and pose risks of off-target ventricular block. LY294002 was reported to inhibit the ultrarapid delayed-rectifier potassium current ( ) carried by Kv1.5 channels, a promising atrium-selective therapeutic target for AF. To determine whether LY294002 exhibits functional selectivity for , this study comprehensively examined its inhibitory effects on major counter-target cardiac ion currents. - Source: PubMed
Publication date: 2026/09/09
Niu RuiLi JiaweiFang HuanleZhao WeiDong ChaoHan NingjuanChen MengyuanMa LieLi LiangFan YunZhu BingBie BeibeiWu JieMatsuura HiroshiHorie Minoru - Benzo[a]pyrene (BaP) is a polycyclic fragrant hydrocarbon contaminant commonly establish throughout the surroundings. The International Agency for Research on Cancer has classified it as a Group 1 carcinogen; however, its exact contribution to the onset of prostate cancer (PCa) is still not well defined. This study systematically explores the mechanism underlying the association between BaP exposure and prostate cancer using approaches including network toxicology, machine learning, transcriptomic validation, immune infiltration assessment, single-cell analysis, molecular docking and external validation. The results showed that BaP and prostate cancer shared 975 overlapping targets, which were predominantly enriched in signaling pathways such as PI3K-Akt. Four core genes were screened out through differential analysis and machine learning, namely CAV1, TWIST1, PRKCA, and GDF15. Transcriptome verification showed that TWIST1 and GDF15 were up-regulated, CAV1 and PRKCA were down-regulated, and the AUC of the four-gene combined diagnosis reached 0.990. Core genes are associated with cellular growth and immune cell recruitment, and single-cell sequencing verified their specific cellular distribution and immunological shifts. Molecular docking showed that BaP binds well to the core target. External validation confirmed that BaP may promotes the progression of PCa, with upregulated expression of GDF15 and downregulated expression of PRKCA in PCa. In conclusion, BaP may promote the development of PCa by regulating pathways such as CAV1, TWIST1, GDF15 and PRKCA. - Source: PubMed
Publication date: 2026/09/23
Zhu SiqiLi ZhuangJiang KehuaSun FaZhu Jianguo - Evidence suggests dietary cholesterol intake associates with higher diabetes risk, but mechanisms need further study. Glucagon-like peptide-1 (GLP-1), a glucose-regulating hormone produced by intestinal L-cells, has served as the basis for widely used diabetes therapeutics. However, how dietary cholesterol and intracellular cholesterol in L-cells affects GLP-1 and glucose regulation remains unclear. We studied ABCA1 (a cholesterol efflux protein) in L-cells using L cell specific gene null nice ( ) mice and ABCA1-targeted interventions in STC-1 and GLUTag cells. A high-cholesterol diet induced mouse glucose intolerance and reduced GLP-1. mice showed worse hyperglycemia and GLP-1 impairment disrupted caveolin-1--catenin signaling. overexpression and cholesterol depletion in STC-1 and GLUTag cells enhanced the CAV1--catenin pathway and GLP-1 secretion, whereas cholesterol loading, siRNA knockdown, and treatment with probucol (an ABCA1 inhibitor) produced opposite effects. The findings of this study confirm that ABCA1 is a key regulator in maintaining cholesterol homeostasis in intestinal L cells and in the synthesis and secretion of GLP-1. Moreover, the regulatory effect of ABCA1 on GLP-1 is mediated through the CAV1--catenin signaling pathway. These observations further uncover promising therapeutic targets for metabolic disorders linked to diabetes. - Source: PubMed
Publication date: 2026/07/16
Gao LuyangLin YubiYe QianqianZhao YuhangHe WenxinLv ShijieYang KeChen JiaZhang ZhenXiang XinxinXu Geyang