Bovine Interleukin 8,IL-8 ELISA Kit
- Known as:
- Bovine Interleukin 8,Interleukin-8 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E0001BO
- Product Quantity:
- 48T
- Category:
- Elisa Kits
- Supplier:
- JING
- Gene target:
- Bovine Interleukin 8 IL-8 ELISA Kit
Related genes to: Bovine Interleukin 8,IL-8 ELISA Kit
- Gene:
- CXCL8 NIH gene
- Name:
- C-X-C motif chemokine ligand 8
- Previous symbol:
- IL8
- Synonyms:
- SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR1 NIH gene
- Name:
- C-X-C motif chemokine receptor 1
- Previous symbol:
- CMKAR1, IL8RA
- Synonyms:
- CKR-1, CDw128a, CD181
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-09
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2 NIH gene
- Name:
- C-X-C motif chemokine receptor 2
- Previous symbol:
- IL8RB
- Synonyms:
- CMKAR2, CD182
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2P1 NIH gene
- Name:
- C-X-C motif chemokine receptor 2 pseudogene 1
- Previous symbol:
- IL8RBP, CXCR2P
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- pseudogene
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-03-14
Related products to: Bovine Interleukin 8,IL-8 ELISA Kit
Related articles to: Bovine Interleukin 8,IL-8 ELISA Kit
- Excessive exposure to UVB can induce inflammatory responses and oxidative stress, leading to skin damage. Peony seed oil is rich in unsaturated fatty acids and has been reported to possess anti-inflammatory and antioxidant properties. This study investigated the protective effects and underlying mechanisms of Paeonia delavayi seed oil (PDSO) against UVB-induced damage in human keratinocytes. PDSO at 30-120 μg/mL attenuated UVB-induced inflammation by reducing the mRNA expression of TNF, IL6, CXCL8, and PTGS2 and suppressing the secretion of IL-6 and IL-8. PDSO also inhibited UVB-induced activation of NF-κB signaling. Regarding oxidative stress, 120 μg/mL PDSO reduced intracellular ROS production, decreased MDA levels by approximately 29.4%, and increased SOD activity by approximately 122.0% compared with the UVB group. PDSO also increased the mRNA expression of antioxidant-related genes, including NFE2L2, HMOX1, SOD1, CAT, GCLC, and GCLM. In addition, PDSO alleviated the UVB-induced reduction in keratinocyte viability and attenuated photoaging-related changes. Transcriptomic analysis identified PI3K/Akt signaling as a candidate pathway associated with PDSO treatment, and western blotting further showed that PDSO inhibited UVB-induced PI3K/Akt signaling. Pharmacological intervention with the PI3K activator 740YP partially reversed the anti-inflammatory effects of PDSO, whereas LY294002 exerted anti-inflammatory effects and further enhanced those of PDSO. Moreover, oleic acid and linolenic acid alleviated UVB-induced inflammation and oxidative stress. Collectively, PDSO protects keratinocytes against UVB-induced damage, with PI3K/Akt and NF-κB signaling contributing to its protective effects. - Source: PubMed
Publication date: 2026/09/26
Wang RencongXu PengZhang YindiJin XiaoliZhao ZiyanQu LipingWang Feifei - Musk has traditionally been used for cardiovascular disorders, but its active constituents and mechanisms of action in acute myocardial infarction (AMI) remain unclear. - Source: PubMed
Lu FengWang QinyuWang DanDuan HuxinyueHe YacongWu Chunjie - Age-related macular degeneration (AMD) is a leading cause of vision loss, with inflammatory and genetic factors contributing to its development. This study examined the association of IL-8 polymorphisms (rs4073, rs2227306, rs2227543) and serum IL-8 levels in a North Indian AMD cohort. A case-control study involving 160 AMD patients and 100 controls was performed. AMD was confirmed through detailed clinical evaluation and diagnostic imaging. Genomic DNA was extracted and genotyped using PCR followed by Sanger sequencing, and serum IL-8 concentrations were determined by ELISA. Statistical analyses were conducted using SPSS v22.0 and SNPstats. AMD patients exhibited significantly higher serum IL-8 levels than control (p < 0.001). ANCOVA adjusting for age and smoking confirmed elevated IL-8 in AMD (adjusted mean: 63.52 pg/ml vs. 41.23 pg/ml in controls; p < 0.001), with higher levels in wet AMD than dry AMD (67.75 pg/ml vs. 54.32 pg/ml; p = 0.043). The IL-8 rs4073 AA genotype and A allele were more frequent in AMD patients (p = 0.006 and p = 0.011, respectively). Multivariate logistic regression showed strong associations between rs4073 AA genotype and AMD risk under codominant (adjusted OR = 2.68; 95% CI: 1.17-6.15; p = 0.025), recessive (adjusted OR = 2.68; 95% CI: 1.27-5.67; p = 0.0067), and log-additive (adjusted OR = 1.50; 95% CI: 1.02-2.20; p = 0.036) models. No significant associations were observed for rs2227306 or rs2227543. Among all participants, AA carriers had significantly higher serum IL-8 levels than TT and AT genotypes (p = 0.018 and p < 0.001). The IL-8 rs4073 AA genotype and elevated serum IL-8 levels may serve as potential markers for AMD susceptibility in the North Indian population. - Source: PubMed
Publication date: 2026/09/26
Yadav AnshuPhogat JitenderYadav ManojBhardwaj AartiPanghal VishalGoel SupremeVerma MamtaSharma SapnaSingh MayankKumar RakeshTanwar Mukesh - Hepatocellular carcinoma (HCC) carries dismal prognosis, and the tumor immune microenvironment (TIME) critically determines the efficacy of SBRT-based radio-immunotherapy; yet its single-cell architecture remains undefined. - Source: PubMed
Publication date: 2026/09/11
Zhang XiaofeiMa XiaohanChen ShengMo YuanjunLu XuqunXie YoukeLiu XudongHou Encun - () belongs to the genus of the family. In goats, infection can result in respiratory diseases such as pneumonia and bronchopneumonia. In this study, caprine bronchial epithelial cells were infected with , and multi-omics integration analysis was conducted to investigate the immune defense mechanisms triggered by the infection. Enrichment analysis of differentially expressed genes (DEGs) using the KEGG database revealed that immune-related signaling pathways involving TNF and IL-17 were among the top 20 most enriched. Based on the TNF and IL-17 signaling pathways, ten immune pathway-related genes, including , , , , , , , , , and , were selected for RT-qPCR validation. In addition, four miRNAs targeting genes involved in the above pathways, namely chi-miR-148a-5p, miR-1285-z, miR-16-x, and miR-6119-x, were verified by RT-qPCR. The expression trends of chi-miR-148a-5p and miR-1285-z were consistent with microRNA sequencing results. Furthermore, gain- and loss-of-function experiments indicated that chi-miR-148a-5p may target and , while miR-1285-z may target , with predicted as a potential target. This study suggests that chi-miR-148a-5p and miR-1285-z may participate in the TNF and IL-17 signaling pathways by regulating their predicted target genes. Moreover, the TNF and IL-17 signaling pathways are among the most highly enriched immune-related pathways involved in the innate immune response of caprine bronchial epithelial cells. This study provides insights into the molecular mechanisms underlying immune responses in goats infected with . - Source: PubMed
Publication date: 2026/09/12
Chen YimeiGong ZhenxingJing HuiDuan HaoQian HejieLi TengjiaoNiu ShihuaWu LiliWang ZiyingZhang MengqiCheng YiwenMan ChurigaChen QiaolingDu LiChen SiGao HongyanWang Fengyang