Bovine Interleukin 8,IL-8 ELISA Kit
- Known as:
- Bovine Interleukin 8,Interleukin-8 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E0001BO
- Product Quantity:
- 48T
- Category:
- Elisa Kits
- Supplier:
- JING
- Gene target:
- Bovine Interleukin 8 IL-8 ELISA Kit
Related genes to: Bovine Interleukin 8,IL-8 ELISA Kit
- Gene:
- CXCL8 NIH gene
- Name:
- C-X-C motif chemokine ligand 8
- Previous symbol:
- IL8
- Synonyms:
- SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR1 NIH gene
- Name:
- C-X-C motif chemokine receptor 1
- Previous symbol:
- CMKAR1, IL8RA
- Synonyms:
- CKR-1, CDw128a, CD181
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-09
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2 NIH gene
- Name:
- C-X-C motif chemokine receptor 2
- Previous symbol:
- IL8RB
- Synonyms:
- CMKAR2, CD182
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2P1 NIH gene
- Name:
- C-X-C motif chemokine receptor 2 pseudogene 1
- Previous symbol:
- IL8RBP, CXCR2P
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- pseudogene
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-03-14
Related products to: Bovine Interleukin 8,IL-8 ELISA Kit
Related articles to: Bovine Interleukin 8,IL-8 ELISA Kit
- Chronic inflammation is involved in the pathogenesis of coronary artery disease (CAD). This case-control study investigated whether the systemic inflammatory response reflects the status of CAD by evaluating the expression of four genes in the IL-1R/TLR pathway (IRAK1, TRAF6, MAPK1, and CXCL8) in peripheral blood mononuclear cells (PBMCs). - Source: PubMed
Publication date: 2026/09/18
Subramanian VinodhiniKumar M JeevanMuralidharan T RVenkatesan Vettriselvi - Inflammation after lumbar disc herniation (LDH) may contribute to radicular pain while also participating in resorption of herniated disc material. Whether circulating immune profiles are associated with these endpoint-specific recovery patterns remains uncertain. - Source: PubMed
Publication date: 2026/09/03
Shen WeiYang KeLiu YangHao TianZhou HaiyuHuang Hua - Amikacin, an aminoglycoside antibiotic for severe Gram-negative infections, is limited by dose-dependent nephrotoxicity. However, its acute kidney injury (AKI) risk profile and underlying molecular mechanisms remain insufficiently characterized in real-world settings. This study integrated real-world data with computational biology approaches. Pharmacovigilance analysis was performed using the FDA Adverse Event Reporting System (FAERS) to identify the risk of acute AKI associated with amikacin. Network toxicology was utilized to screen shared targets, while molecular docking and dynamics simulations were conducted to evaluate binding interactions. The expression of core genes was validated using GEO datasets. Disproportionality analysis indicated a significant amikacin-AKI association. Injectable formulation posed higher risk than inhalation (OR = 7.47). Male sex and age ≤ 65 years were independent risk factors. Network toxicology identified IL1B, CXCL8, SIRT1, and PTGS2 as hub genes. Molecular docking showed strong binding (SIRT1, - 7.789 kcal/mol; PTGS2, - 9.467 kcal/mol), with dynamics indicating stability over 100 ns. GEO analysis corroborated the predicted upregulation of IL1B and CXCL8 in AKI, and further supported the involvement of PTGS2, which was significantly upregulated in a cisplatin‑induced AKI model. This study delineates the risk profile of amikacin-associated AKI and elucidates a molecular mechanism involving multi-target interactions in renal injury induction, thereby offering a theoretical basis and identifying potential molecular targets for further investigation into clinical risk mitigation strategies. - Source: PubMed
Publication date: 2026/09/18
Li ChaoWu WeiLiao JingliGu FenfenLi Lixia - A gel preparation derived from the traditional Chinese medicine formula QinZhuLiangXue (QZLX), a herbal formula for clinical psoriasis treatment, was developed as a potential alternative to existing topical treatments for psoriasis and to meet clinical expectations. Nonetheless, the exact mechanisms of its action against this condition remain to be clarified. - Source: PubMed
Publication date: 2026/09/17
Yuan WeixuanSun SutingMa TianyouXie MengjiHuang YuKuai LeLuo YingSong JiankunDing XiaojieRu YiLuo YueFei XiaoyaDeng GuoshuHong SeokgyeongSu YonghuaWang RuipingYang DanZhang YingLi MiaoZhou MiLi BinTai Zongguang - Objective Interleukin-1 receptor 8 (IL-1R8) is significantly upregulated in activated natural killer (NK) cells and serves as a critical negative regulator governing the anti-tumor immune activity of NK cells. This study aims to silence IL-1R8 expression in ex vivo expanded NK cells, and further elucidate the underlying molecular mechanism by which IL-1R8 modulates NK cell-mediated anti-tumor immunity against hepatocellular carcinoma (HCC). Methods IL-1R8 expression was knocked down in ex vivo expanded NK cells using lentivirus-derived IL-1R8 short hairpin RNA (shRNA), and the knockdown efficiency was verified by real-time quantitative PCR (qPCR) and Western blotting. Trypan blue staining was used to assess NK cell proliferation, while flow cytometry analyzed changes in the expression of major phenotypic receptors before and after IL-1R8 knockdown. A lactic dehydrogenase (LDH) release assay evaluated the in vitro cytotoxicity of NK cells against HCC cells, and ELISA measured the secretion levels of cytokines and chemokines during the killing process. A Huh7 xenograft mouse model was established to verify the in vivo anti-tumor therapeutic efficacy of IL-1R8-silenced NK cells. Immunohistochemical staining was performed to detect the intratumoral levels of NK cells within tumor tissues. Results Knockdown of IL-1R8 exerted no significant effects on the proliferation capacity and surface phenotypic characteristics of ex vivo expanded NK cells. Nevertheless, IL-1R8 downregulation remarkably potentiated the cytotoxicity of NK cells against HCC, and facilitated the secretion of multiple core anti-tumor cytokines and chemokines, including tumor necrosis factor α (TNF-α), interferon γ (IFN-γ), C-C motif chemokine ligand 3 (CCL3) and C-X-C motif chemokine ligand 8 (CXCL8). In vivo animal experiments demonstrated that adoptive transfer of IL-1R8-knockdown NK cells significantly suppressed subcutaneous HCC tumor growth, meanwhile enhanced NK cell recruitment and infiltration in the tumor microenvironment. Conclusion Genetic ablation of IL-1R8 efficiently augments the anti-tumor effector function of NK cells against HCC both in vitro and in vivo, highlighting IL-1R8 as a promising target to improve the efficacy of NK cell-based therapies for cancer treatment. - Source: PubMed
Song JianglingZuo QingqingZhang ShengjieYu MinLi JianfengLiu Longzi