Rabbit Interleukin 6,IL-6 ELISA Kit
- Known as:
- Rabbit Interleukin 6,Interleukin-6 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E0002Rb
- Product Quantity:
- 48T
- Category:
- Elisa Kits
- Supplier:
- JING
- Gene target:
- Rabbit Interleukin 6 IL-6 ELISA Kit
Related genes to: Rabbit Interleukin 6,IL-6 ELISA Kit
- Gene:
- CEBPB NIH gene
- Name:
- CCAAT enhancer binding protein beta
- Previous symbol:
- TCF5
- Synonyms:
- LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1991-02-27
- Date modifiied:
- 2018-02-23
- Gene:
- CEBPD NIH gene
- Name:
- CCAAT enhancer binding protein delta
- Previous symbol:
- -
- Synonyms:
- CRP3, CELF, C/EBP-delta, NF-IL6-beta
- Chromosome:
- 8q11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-24
- Date modifiied:
- 2018-02-23
- Gene:
- ENTPD6 NIH gene
- Name:
- ectonucleoside triphosphate diphosphohydrolase 6
- Previous symbol:
- CD39L2, IL6ST2
- Synonyms:
- NTPDase-6, dJ738P15.3
- Chromosome:
- 20p11.21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-20
- Date modifiied:
- 2019-02-28
- Gene:
- IL6 NIH gene
- Name:
- interleukin 6
- Previous symbol:
- IFNB2
- Synonyms:
- IL-6, BSF2, HGF, HSF
- Chromosome:
- 7p15.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2017-07-12
- Gene:
- IL6RP1 NIH gene
- Name:
- interleukin 6 receptor pseudogene 1
- Previous symbol:
- IL6RL1
- Synonyms:
- -
- Chromosome:
- 9q22.2
- Locus Type:
- pseudogene
- Date approved:
- 1991-08-18
- Date modifiied:
- 2014-11-19
Related products to: Rabbit Interleukin 6,IL-6 ELISA Kit
Related articles to: Rabbit Interleukin 6,IL-6 ELISA Kit
- This research employs a molecular hybridization strategy to repurpose the pyrazoline scaffold 6a, 6c, 7a-c, 11a, and 12b, transforming it into a high-efficiency conjugate designed to tackle the multifaceted pathology of neuroinflammation and epilepsy. By integrating a selective phenoxyacetic acid moiety. Our findings identified compound 7c as a potential lead candidate for the development of novel anticonvulsant agents. In vivo trials demonstrated that 7c offers a superior therapeutic window compared to valproic acid, yielding 90% seizure protection in PTZ models and a remarkable 212.27% delay in seizure onset within the pilocarpine model, alongside 100% survival. Beyond mere symptomatic suppression, 7c re-engineers the hippocampal environment by slashing glutamate-driven excitotoxicity by 64.23% and silencing the cytokine-glial activation axis (TNF-alpha, IL-6, GFAP, and Iba-1). Supported by ADME profile confirming optimal BBB permeability and molecular docking indicating a robust binding affinity of -10.3 kcal/mol, this study positions 7c as a versatile, non-toxic, and repurposed-ready hybrid candidate for advanced neuroprotective intervention. - Source: PubMed
Alqarni Mohammad HAlkabbani Mahmoud AbdelrahmanIbrahim Aya Mohamed AhmedFoudah Ahmed IAljarba Tariq MAlam AftabAbdel-Aziz Hatem AElgohary Mohamed K - Cyclooxygenase (COX) plays a crucial role in the inflammatory response, making selective COX-2 inhibition a significant strategy for developing safer anti-inflammatory medications. Accordingly, developing new pharmacotherapies is a critical objective in anti-inflammatory drug discovery. In this study, a new pyrazole-linked pyridine derivatives 2-7 were synthesized through the reaction of the 4-(pyridin-1-yl)benzohydrazide derivative 1 with substituted-ketenes, activated olefinic dimers, and α,β-unsaturated carbonyl compounds. The synthesized derivatives were characterized and subsequently assessed in vitro for their inhibitory effects on COX-2. The results of the COX-2 inhibition assay revealed a broad range of activity, with IC values ranging from 0.70 ± 0.02 to 63.49 ± 2.32 µM. Among the derivatives, 3 and 7b demonstrated the most significant inhibitory effects, with IC values of 1.11 ± 0.04 and 0.70 ± 0.02 µM, respectively, compared to celecoxib (IC = 0.87 ± 0.03 µM). Furthermore, these promising derivatives exhibited COX-1 inhibitory activity, with IC values of 16.08 ± 0.54 µM (SI = 14.48) and 2.77 ± 0.09 µM (SI = 3.95), respectively, compared to indomethacin (0.199 ± 0.01 µM) and celecoxib (21.62 ± 0.73 µM). Given the extensive COX activity of 7b, further investigations were conducted, as it demonstrated immunomodulatory potential through the suppression of IL-6 (IC = 167.65 ± 6.65 pg/mL) and TNF-α (IC = 816.59 ± 28.01 pg/mL) compared to celecoxib's IC (129.50 ± 4.44 pg/mL) and (399.7 ± 13.7 pg/mL), respectively. Additionally, pyrazole-linked pyridine derivative 7b significantly reduced PGE2 levels to 539.49 ± 17.87 pg/mL and NO production to 4.230 ± 0.159 nM, compared to celecoxib 256.79 ± 8.50 pg/mL for PGE2 and 3.997 ± 0 nM for NO, respectively, suggesting that compound 7b can attenuate both cytokine and eicosanoid signaling, exhibit extensive anti-inflammatory activity, and may serve as a potential multi-target therapeutic agent. The molecular docking simulation revealed that compound 7b exhibited a significant binding affinity through various interactions. Finally, the DFT calculation indicated that 7b has a low energy band gap, which suggests lower hardness and higher softness that implies a greater ability to redistribute electron density during binding, favoring the formation of stable polar interactions with protein residues. Overall, these findings demonstrate that compound 7b is a promising multi-target anti-inflammatory lead drug with strong COX-2 inhibition and immunomodulatory properties. Moreover, further studies will concentrate on in vivo anti-inflammatory evaluation and pharmacokinetic profiling. - Source: PubMed
Salem Mohamed ARaslan Reham RGohar Nirvana AAbusaif Moustafa SAmmar Yousry ARagab Ahmed - Meniere's disease is a complex chronic inner ear condition that is characterized by vertigo, tinnitus, aural fullness, and progressive hearing loss. Currently, diagnostic strategies remain symptom-driven, and treatments focus on management of discrete episodes rather than targeting underlying pathophysiology. This review sets out to evaluate the diagnostic and therapeutic utility of molecular biomarkers derived from blood and endolymphatic fluid in MD. - Source: PubMed
Publication date: 2026/08/17
Kamran HamzaJimoh ZaharadeenIssa TariqGomaa Nahla A - The high incidence of posttraumatic osteoarthritis after anterior cruciate ligament (ACL) injury and reconstruction suggests that biological mechanisms beyond joint instability contribute to disease progression. After injury, ACL-resident cells are exposed to inflammatory mediators within the joint and may influence the local inflammatory microenvironment; however, their global transcriptomic responses to inflammatory stimuli remain underexplored. - Source: PubMed
Publication date: 2026/08/17
Cai LeiBrophy Robert HTycksen Eric DRai Muhammad Farooq - Interesterified fats have become a common source of fat for the food industry, however, their role in metabolic programming remains poorly understood. This study investigated whether maternal consumption of a normocaloric diet containing interesterified palm oil, starting prior to conception until the end of lactation, could trigger metabolic impairments in young offspring. Female C57BL/6J mice were fed a normocaloric diet containing either palm oil (P) or interesterified palm oil (INP) for four weeks before mating and throughout gestation and lactation. After the preconceptional period, the dams' metabolic profile was evaluated. At postnatal day 30 (d30), male and female offspring were evaluated for glucose and insulin tolerance, tissue-specific insulin signaling and inflammatory profile, and hypothalamic neuropeptide expression. Even before mating, INP-fed dams exhibited hyperphagia, increased body weight, reduced energy expenditure, increased NPY and decreased POMC neuronal labeling in the hypothalamus. In the offspring, maternal INP exposure induced a pronounced sexual dimorphism, despite no differences in body weight or adiposity. Female offspring showed systemic glucose intolerance and impaired insulin sensitivity, supported by reduced pAKT levels in skeletal muscle and white adipose tissue (gWAT). In contrast, male offspring maintained functional glucose tolerance but showed tissue-specific molecular impairments, including reduced hepatic pAKT levels and a paradoxical compensatory increase in gWAT pAKT levels. Both sexes exhibited a pro-inflammatory profile, with upregulation of across all tissues and an increase in and in gWAT and the hypothalamus. These findings demonstrate that INP disrupts maternal neuroendocrine homeostasis and predisposes offspring to early-life insulin resistance, glucose intolerance, specifically in female offspring, and systemic inflammation. - Source: PubMed
Publication date: 2026/08/17
Villalta Paloma BrasilioMartins Fernandez Malentachi LuizaPanzarin CarolinaBaqueiro Mayara da NóbregaSimino Laís Angélica de PaulaIgnácio-Souza LetíciaTorsoni Marcio AlbertoMilanski MarcianeTorsoni Adriana Souza