Hamster adiponectin,ADP ELISA Kit
- Known as:
- Hamster adiponectin,ADP Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E0010Ha
- Product Quantity:
- 48T
- Category:
- Elisa Kits
- Supplier:
- JING
- Gene target:
- Hamster adiponectin ADP ELISA Kit
Ask about this productRelated genes to: Hamster adiponectin,ADP ELISA Kit
- Gene:
- ADIPOQ NIH gene
- Name:
- adiponectin, C1Q and collagen domain containing
- Previous symbol:
- ACDC
- Synonyms:
- ACRP30, AdipoQ, apM1, GBP28, adiponectin
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-26
- Date modifiied:
- 2016-10-05
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- Polymorphisms in genes involved in obesity-related metabolic pathways are associated with metabolic syndrome (MetS). We hypothesized that variants in FTO, LEP, LEPR, ADRB3, ADIPOQ, TCF7L2, ENPP1, APOA5, PPARG, and CYP11B2 are associated with MetS and obesity-related traits. - Source: PubMed
Publication date: 2026/09/21
Stefani Tamiris Invencioni MoraesHirata Thiago Dominguez CrespoCerda Alvarode Oliveira RaquelDos Santos Marina AparecidaFajardo Cristina MorenoDorea Egídio LimaBernik Márcia Martins SilveiraHirata Mario HiroyukiHirata Rosario Dominguez Crespo - Aging disrupts the coupling between redox homeostasis and energy metabolism in brown adipose tissue (BAT), but the molecular nodes linking BAT redox-metabolic deterioration to systemic metabolic dysfunction remain unclear. Using aging mouse BAT time-course transcriptomics, we prioritized Acss1, encoding mitochondrial acetyl-CoA synthetase 1 (ACSS1), as a progressively age-decreased mitochondrial metabolic candidate. Acss1 expression correlated positively with BAT metabolic programs and negatively with oxidative stress and senescence-associated programs. Age-series single-nucleus transcriptomics further localized Acss1 mainly to adipocytes and classified BAT adipocyte nuclei into Acss1-high and Acss1-low transcriptional states. Acss1-high adipocytes retained thermogenic, oxidative phosphorylation and fatty acid oxidation programs, whereas Acss1-low adipocytes were enriched for stress- and senescence-related programs, with this divergence increasing with age. To test Acss1 function, we locally injected 18-month-old mouse BAT with an adeno-associated virus expressing Acss1 under the adipocyte-specific adiponectin (Adipoq) promoter. BAT-local Acss1 restoration attenuated redox imbalance, restored thermogenic programs and reduced senescence-associated injury. This local intervention also improved glucose and lipid metabolism, energy substrate utilization, motor performance and plasma antioxidant capacity, and was associated with improved histological and stress-related features in distal metabolic tissues. Matched BAT transcriptomic and plasma metabolomic profiling showed that Acss1 restoration shifted BAT redox-metabolic programs and was associated with spermidine-related circulating metabolic remodeling. In human BAT, ACSS1 expression correlated positively with oxidative phosphorylation and negatively with reactive oxygen species metabolic processes. These findings support brown adipocyte Acss1 as a regulator of redox-metabolic homeostasis in aged BAT, whose restoration is associated with improved local BAT state, improved systemic metabolic phenotypes and spermidine-related circulating metabolic remodeling. - Source: PubMed
Publication date: 2026/09/18
Luo YuchengZhang YuchenSong YuangLi XiangtianLiang JiancongXing HaonanLai YujinChen YinuoZeng MinxiZhou ChengChen HuishanWang WenqiLi YeLi BinLu FengDong Ziqing - Hypothermia is a life-threatening condition lacking specific pharmacological treatments. This study aimed to prioritize genetically supported molecular loci associated with hypothermia and to explore their pharmacological tractability using multi-omics data. - Source: PubMed
Publication date: 2026/09/15
Ran ShuShi XiaolongZhang JinbaoPeng HaoLi Yuehua - In birds, sperm storage tubules (SSTs) located at the uterovaginal junction (UVJ) facilitate long-term sperm storage and regulate sperm release in coordination with ovulation. In Japanese quail (Coturnix japonica), sperm release from SSTs might be mediated by membrane progestin receptor α (mPRα), encoded by the progestin and adipoQ receptor family member 7 (PAQR7) gene. Although PAQR7 plays an important role in reproductive functions, the mechanisms regulating its transcription remain unclear. Therefore, in this study, we investigated the transcriptional regulatory mechanisms of PAQR7 in Japanese quail SSTs. Reporter assays using serial deletion constructs identified multiple positive and negative regulatory regions within the 5' upstream region of PAQR7. Analysis of the proximal promoter region revealed a putative initiator element and non-canonical promoter structure. Electrophoretic mobility shift assays identified several nuclear protein-binding regions within the upstream regulatory region. Candidate transcription factors potentially binding to these regions were predicted using JASPAR and RNA-Seq transcriptome data. Quantitative PCR further revealed that FOS, JUN, FOXN1, and SOX17 levels were significantly upregulated in SST-containing tissues compared to those in non-SST epithelial tissues. Overall, our findings suggest that PAQR7 expression in SSTs is regulated by an SST-specific transcriptional environment involving activator protein-1 (AP-1; FOS-JUN complex), JUN, FOXN1, and SOX17. These findings provide new insights into the transcriptional regulation of progesterone responsiveness in avian reproductive tissues and advance our understanding of endocrine mechanisms underlying sperm storage. - Source: PubMed
Publication date: 2026/09/15
Matsuzaki MeiIchikawa KennosukeTerada TakumiEzaki RyoHoriuchi HiroyukiOhkubo TakeshiSasanami Tomohiro - Cashmere goat coat types determine cashmere quality and economic value. Elucidating the molecular regulatory mechanisms is crucial for targeted breeding and the development of high-quality cashmere products. - Source: PubMed
Publication date: 2026/08/27
Zhang LiSun HuichengZhang TianshiGuo LiqiWang QishanGuo HongyuHan JieruZhao Peng