Human Semenogelin-1,SEMG1 ELISA Kit
- Known as:
- Human Semenogelin-1,SEMG1 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E3266Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- JING
- Gene target:
- Human Semenogelin-1 SEMG1 ELISA Kit
Related genes to: Human Semenogelin-1,SEMG1 ELISA Kit
- Gene:
- SEMG1 NIH gene
- Name:
- semenogelin 1
- Previous symbol:
- SEMG
- Synonyms:
- CT103
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-13
- Date modifiied:
- 2018-02-09
Related products to: Human Semenogelin-1,SEMG1 ELISA Kit
Related articles to: Human Semenogelin-1,SEMG1 ELISA Kit
- Smoking is a modifiable risk factor for prostate cancer (PCa) diagnosis, recurrence, and mortality. While the mutagenic effects of tobacco are well-documented, the immunological consequences of smoking within the tumor microenvironment (TME) are poorly understood. This study investigates how smoking reshapes the PCa immune landscape and how the associated changes could potentially be associated with patient survival. - Source: PubMed
Publication date: 2026/02/10
Sharma AmodSudan Sarabjeet KourKhan Mohammad AslamTahir MuhammadNiyogi Pratim GuhaSingh Ajay PSingh Seema - Elevated sodium concentrations are commonly observed in tumors and sites of inflammation. Previous studies have shown that high salt levels modulate the phenotype and function of CD4 and CD8 T cells, regulatory T cells, and macrophages. In this study, we performed transcriptomic studies that revealed profound alterations in the neutrophil transcriptome upon high salt exposure, with changes that significantly exceeded those triggered by conventional agonists. By integrating transcriptomic data with functional assays, our findings suggest that high salt-induced neutrophil activation involves mitochondrial ROS production, which subsequently activates p38 MAPK and engages FOS-, Bruton's tyrosine kinase (BTK)-, and cyclooxygenase 2 (COX2)-dependent pathways. Remarkably, the plasticity of the neutrophil transcriptome in response to high salt was further evidenced by the upregulation of genes typically associated with other cell types, including semenogelin 1 (), intercellular adhesion molecule-4 (), tripartite motif69 (), amphiregulin (), oncostatin (), and transducer of ERBB2-1 (), suggesting a broader role for neutrophils in different biological processes beyond their participation in innate immunity. - Source: PubMed
Publication date: 2026/01/21
Mazzitelli IgnacioBleichmar LucíaRivelli FedericoFeijoo IngridAdamczyk AlanCabrerizo GonzaloErra Díaz FernandoGeffner Jorge - Serological screening, including immunological lateral flow assays, remains common for body fluid identification in sexual assault investigations but lacks the sensitivity and specificity of modern DNA profiling. To address this gap, alternative molecular approaches, including MS-based proteomics, have been explored. However, adoption is hindered by lengthy bottom-up workflows and reliance on research-grade instrumentation. Here, a streamlined, protease-free assay for the identification of saliva and seminal fluid in sexual assault evidence is described. Casework-type body fluid samples were extracted in a single step and analyzed by targeted DDA on a Q Exactive MS with a 25-min separation and data search using Byos software. The 96-well plate format used is amenable to higher-throughput automation. Discovery data sets included 50 saliva and 60 semen samples (including samples from 5 vasectomized males). This resulted in the identification of 7 saliva biomarkers (PRB1, PRB2, PRB4, PRH1, STATH, HTN1, and SMR3B) and 5 seminal fluid biomarkers (SEMG1, SEMG2, PSA, PAP, and PIP). Peptide standards were synthesized to confirm the discovery results and to develop a targeted assay. The method was successfully validated using 168 forensic casework-type samples, including diluted, laundered, and environmentally challenged samples on a variety of substrates. - Source: PubMed
Publication date: 2025/11/12
Brown Catherine OParker Glendon JWestring Christian GDanielson Phillip BLegg Kevin M - Notable variations in semen parameters among non-smoking males have been documented post-COVID-19 pandemic. The role of smoking as a significant contributing factor to male infertility has been substantiated. Does the combined effect of smoking and SARS-CoV-2 infection impact male reproductive function? A prospective descriptive cohort study was performed using data from 90 smoking and 90 non-smoking males before and after coronavirus infection in a single center over a period of 3 months. Semen samples were collected before and within 15 days after COVID-19 infection, ensuring no more than three months elapsed between the two collections. The semen parameters evaluated included volume, concentration, progressive motility, normal morphology, and DNA fragmentation rate. Proteomic and metabolomic studies were further used to explore the differences between groups. Both non-smokers and smokers exhibited a marked reduction in sperm concentration, progressive motility, and normal morphology rate. Additionally, an increase in sperm DNA fragmentation index was noted for non-smokers and smokers. In the non-smoking group, dysregulation proteins including SEMG1, SEMG2 and DNAH5, and metabolites including L-glutamine, cis-9-Palmitoleic acid and Linoleamide were observed. In smokers, dysregulation proteins including SMCP, ROPN1B and IZUMO4, alongside metabolites including carnitine, gamma-Glutamylglutamic acid, and hypoxanthine were found. Comparative analysis between smoking and non-smoking patients post-COVID-19 also revealed significant differences in semen concentration, morphology and sperm DNA fragmentation rate. Dysregulated proteins including HSPA5, HSPA2 and PGK2, and metabolites such as acetylcarnitine, oxaloacetate and nicotinate were associated with impaired sperm function. Our study demonstrates that the virus also significantly compromises sperm quality in smoking males, who experience more pronounced declines post-infection compared to their non-smoking counterparts. This research underscores the necessity for comprehensive fertility assessments for smoking males after recovering from COVID-19. - Source: PubMed
Publication date: 2024/10/13
Wang ChengLuZhang JiaChengGao FangZheng MinFu XiaoHuaYang KeBing - This study aimed to investigate the expression and biological significance of Semenogelin 1 (SEMG1), a member of the cancer-testis antigen family, in oral squamous cell carcinoma (OSCC). Further, we explored its potential association with metabolism-related molecules. - Source: PubMed
Publication date: 2024/08/18
Wang JingZhong Nian-NianYi Jing-RuiLiu Xuan-HaoWang Han-QiLiu BingMan Qi-WenBu Lin-Lin