Human Clock Homolog (CLOCK) ELISA Kit
- Known as:
- Human Clock Homolog (CLOCK) Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- DL-CLOCK-Hu
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- Yukichj
- Gene target:
- Human Clock Homolog (CLOCK) ELISA Kit
Related genes to: Human Clock Homolog (CLOCK) ELISA Kit
- Gene:
- CLOCK NIH gene
- Name:
- clock circadian regulator
- Previous symbol:
- -
- Synonyms:
- KIAA0334, KAT13D, bHLHe8
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-04-19
- Date modifiied:
- 2015-09-11
Related products to: Human Clock Homolog (CLOCK) ELISA Kit
Related articles to: Human Clock Homolog (CLOCK) ELISA Kit
- Thyroid cancer (TC), the most common endocrine malignancy, is closely linked to aging. In this study, we estimated DNA methylation (DNAm) age in TC tissues versus adjacent non-cancerous thyroid tissues using TCGA and GSE97466 datasets. - Source: PubMed
Publication date: 2026/06/24
Hou YihanLuo ChenwenYao YaoLuo Yongping - The purpose of this study was to quantify the three-dimensional distribution of estimated acetabular bone requiring reaming during virtual cup placement in total hip arthroplasty (THA) for hip osteoarthritis (OA), providing a quantitative reference for direction-specific reaming patterns. - Source: PubMed
Publication date: 2026/06/24
Funahashi HirotoOsawa YusukeIdo HiroakiAsamoto TakamuneTakegami YasuhikoImagama Shiro - The circadian clock and gut microbiome are integral regulators of metabolic homeostasis, with disruptions in either system contributing to obesity pathogenesis. Roux-en-Y gastric bypass (RYGB) effectively treats severe obesity, yet the mechanisms underlying its benefits remain incompletely characterized. We investigated the impact of RYGB on cecal gut microbial composition and function using 16S rRNA sequencing in relation to host circadian gene expression and metabolic parameters in diet-induced obese mice. Diet-induced obese mice underwent RYGB or sham surgery and were compared with lean controls across multiple circadian Zeitgeber time (ZT) points (ZT3, ZT9, ZT15, ZT21). Principal component analysis at the ASV level revealed significant differences in all ZT points (ZT3, ZT9, ZT15, and ZT21) in the lean and sham-operated mice; however, only a significant difference between ZT9 and ZT21 was observed in RYGB mice. Microbial gene counts and microbial pathways were also different between RYGB and sham-operated mice, with several correlating with hepatic and gene expression. Notably, specific taxa showed differential associations with glucose homeostasis, independent of surgical intervention. These findings demonstrate that RYGB alters the gut microbiome and host circadian rhythms, suggesting an association between microbial remodeling, circadian gene expression, and metabolic improvement following bariatric surgery. - Source: PubMed
Publication date: 2026/06/24
Moutsoglou DaphneJarrah MohammadJaques JessicaAguilar LeeannShahi Shailesh KMangalam Ashutosh KMokadem Mohamad - Computational simulation provides a powerful toolkit for in silico experimentation. However, while the field has developed best practices for the design and implementation of such models, there remains ambiguity in discussions about how to understand and/or interpret their results due to their inherent ability to overwhelm traditional frequentist statistics by simply increasing the number of trials simulated. This fails the discipline in two ways: first, it leaves the community unsure of what constitutes a best practice for uniform understanding, and second, it potentially overburdens computational studies that burn clock cycles solely to ensure "enough runs to satisfy peers" without any theoretical underpinning for a definition of "enough". We propose a simple and straightforward standard for when to stop simulating additional trials, the Ω test, designed to be analogous to the function of traditional frequentist P-tests. Community adoption of a reasonable and uniform standard will permit more efficient computational experimentation and clearly communication/interpretation of the findings discovered in this way. - Source: PubMed
Publication date: 2026/06/08
Lofgren Eric TMyers KellenFefferman Nina H - This review examines temporal cognition through the lens of Mental Time Travel (MTT): the subjective experience of recalling past events and using them to construct future scenarios. The analysis specifically addresses how language and cultural context affect these abilities, integrating psychology, linguistics, cognitive neuroscience, and anthropology. Findings from comparative cognition challenge whether they are uniquely human. Although such an approach was traditionally taken in non-human primates, the field of comparative cognition has become much more diverse. Comparative insights derived from studies of corvid and cephalopod cognition are particularly pertinent, as they suggest these abilities have evolved more widely within the animal kingdom, especially in groups with very different neural architectures, raising questions about whether these abilities have evolved convergently in species undergoing similar selection pressures or independently in those subject to different selection pressures, as opposed to homologous evolution widespread amongst these animal taxa. These evolutionary perspectives inform theories of human temporal cognition and Mental Time Travel, influencing memory encoding and retrieval processes, false memory production, as well as the mechanisms underlying temporal cognition, such as episodic memory formation, interval timing, and circadian modulation of memory consolidation. Additionally, the review evaluates evidence on the cognitive impact of technological tools (calendars, clocks, and other technologies) used to externalize and standardize temporal frameworks, including implications for subjective perception and memory accuracy, and identifies directions for future interdisciplinary research. Building on this synthesis, we advance five core claims: that elements of temporal cognition likely arise under convergent evolutionary pressures; that language, culture, and social organization tune how people represent and use time; that technologies which externalize time can reshape behavior by aligning with or pulling against internally constructed event time; that memory is adaptively biased toward flexible, future-oriented construction rather than veridical record; and that these processes are structured by "mind time" and extended via transpersonal extended mental time travel, whereby shared representations support the projection and coordination of futures across individuals and generations. - Source: PubMed
Publication date: 2026/01/21
Pendleton Jeffery R LClayton Nicola S