Mouse forkhead box O4,FOXO4 ELISA Kit
- Known as:
- Mouse forkhead box O4,FOXO4 Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E0998Mo
- Product Quantity:
- 48T
- Category:
- Elisa Kits
- Supplier:
- Sunlog
- Gene target:
- Mouse forkhead box O4 FOXO4 ELISA Kit
Related genes to: Mouse forkhead box O4,FOXO4 ELISA Kit
- Gene:
- FOXO4 NIH gene
- Name:
- forkhead box O4
- Previous symbol:
- MLLT7
- Synonyms:
- AFX1
- Chromosome:
- Xq13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-14
- Date modifiied:
- 2014-11-18
Related products to: Mouse forkhead box O4,FOXO4 ELISA Kit
Related articles to: Mouse forkhead box O4,FOXO4 ELISA Kit
- Trophoblast stem cells (TSCs) have emerged as a valuable model for investigating placentation and related disorders. Despite their ability to be maintained over multiple passages without losing stemness, conventional TSCs are characterised by notorious heterogeneity and a spontaneous differentiation tendency. In this study, we established a type of mouse TSCs with dome-shaped colonies (dTSCs). The dTSCs expressed canonical markers of conventional TSCs and exhibited relatively low levels of heterogeneity and spontaneous differentiation when cultured in conventional trophoblast stem cell medium. Additionally, dTSCs retained robust potential to differentiate into all trophoblast lineages in vitro, as well as the capacity to contribute to placental development in vivo. Furthermore, the functions of Foxo4 and Slc16a3 (MCT4) could be effectively explored in trophoblast development by using our established dTSCs. Collectively, our findings establish a type of high-quality TSCs and define dTSCs as a promising and refined model for investigating trophoblast development. - Source: PubMed
Publication date: 2026/09/18
Liu MinliRen ShaofangXia XinyuLu GuanlinYang HaojieZheng YiZhao JiexiangZhao Xiao-YangWang Mei - OGT-rearranged mesenchymal neoplasm is a rare, molecularly defined soft tissue tumor with an acral predilection and recurrent fusions involving FOXO1, FOXO3, FOXO4, or CITED1. We report a tumor of the left ulnar palm in a 72-year-old woman presenting as a scaly papule. Shave biopsy demonstrated a bland dermal mesenchymal neoplasm composed of epithelioid to spindled cells arranged in cords and small nests within a hyalinized to fibromyxoid stroma. The lesional cells expressed CD34 diffusely and EMA focally, whereas SOX10 and SMA were negative. Targeted RNA sequencing identified a novel in-frame OGT::C3orf62/MAPS fusion joining OGT exon 22 to MAPS exon 3 and predicted to preserve the OGT enzymatic architecture. MAPS is implicated in phase separation and chromatin organization. This case expands the molecular and clinical spectrum of OGT-rearranged mesenchymal neoplasm, documents C3orf62/MAPS as a novel fusion partner, and highlights its dermal papular presentation as a potential diagnostic pitfall in routine dermatopathology. - Source: PubMed
Publication date: 2026/09/14
Repetto FedericoBusam Klaus JKarunamurthy ArivarasanYakoub MohamedLinos Konstantinos - FOXO6 is a member of the FOXO transcription factor family that differs from FOXO1, FOXO3, and FOXO4 in its nucleocytoplasmic regulation, remaining predominantly within the nucleus because it lacks a functional nuclear export sequence. FOXO6 activity can nevertheless be inhibited by insulin/AKT signaling, whereas impaired insulin signaling increases its transcriptional activity in hepatocytes under insulin-resistant and nutrient-rich conditions. Recent studies indicate that FOXO6 regulates hepatic metabolic pathways associated with oxidative injury, inflammatory signaling, and lipid accumulation. In hepatocellular carcinoma, increased FOXO6 expression is associated with glycolytic activity, proliferation, and invasion. We recently reported that FOXO6-dependent transcriptional regulation contributes to reactive oxygen species (ROS) production and inflammasome-associated inflammatory signaling through induction of thioredoxin-interacting protein (TXNIP). Furthermore, FOXO6 regulates lipid metabolic pathways through transcriptional activation of apolipoprotein C3 (ApoC3) and peroxisome proliferator-activated receptor (PPAR) γ together with suppression of PPARα, thereby promoting triglyceride accumulation, mitochondrial dysfunction, and lipotoxic injury in hepatocytes. These metabolic and inflammatory alterations contribute to hepatic steatosis, mitochondrial injury, and inflammatory hepatocellular damage. In hepatocellular carcinoma, increased FOXO6 expression is associated with glycolytic metabolism, angiogenic signaling, proliferative activity, immune suppression, and invasive phenotypes. FOXO6-dependent signaling interacts with STAT3, NF-κB, and β-catenin pathways involved in metabolic adaptation and tumor progression. Recent studies demonstrate relationships between increased FOXO6 expression, vascular invasion, aggressive tumor phenotypes, and reduced survival in hepatocellular carcinoma. This review examines FOXO6-associated transcriptional mechanisms involved in hepatic metabolic inflammation and hepatocarcinogenesis. - Source: PubMed
Kim Mi EunKim YukyeongLee Jun Sik - Gene transcription is a stochastic bursting process with burst frequency and size as core parameters. While complex models capture detailed biology, their computational cost limits genome-wide applications. We propose a simple telegraph model-based framework to analyze genome-wide scRNA-seq datasets. When sample size ≥500 and burst parameter change ≥ 3 fold, inferred burst frequency- and size-dominated variations reliably proxy true regulation. Analyses across mouse cells and healthy/hypertrophic cardiomyopathy (HCM) human heart tissues revealed three conserved principles: (1) over 70% of genes with altered burst regulation exhibited burst frequency- or size-dominated regulation; HCM genes show stronger bursting featuring prolonged inactivity and intense transcription; (2) TATA-initiator synergy is lost in HCM; and (3) burst frequency-dominated genes enriched in genome stability/cell cycle/apoptosis (via TFs like /), while burst size-dominated ones enrich in signaling/metabolism (via TFs like /). Their interdependent dysregulation accelerated HCM. This study establishes the simple telegraph model as a scalable framework linking transcriptional burst dynamics to cell fate and pathology. - Source: PubMed
Publication date: 2026/08/11
Chen LiangWu YuwenYang ChengkaiFang SijiaLiao YuWu YuehengZhang HongkunJiang GuozhiYu JiansheJiao Feng - Diabetic nephropathy (DN) represents the leading cause of end-stage renal disease; however, its molecular mechanisms remain incompletely understood. This study aims to elucidate the specific roles and regulatory mechanisms of Tissue factor pathway inhibitor 2 (TFPI2) and forkhead box O4 (FOXO4) in DN. - Source: PubMed
Publication date: 2026/08/20
Mu LiqinZhao YuLi YangGao WeiWang Jing