IL-17D, Human Recombinant proteins
- Known as:
- Interleukin-17D, Human Recombinant proteins
- Catalog number:
- 7107-50
- Product Quantity:
- 50 μg
- Category:
- Proteins
- Supplier:
- Biovis
- Gene target:
- IL-17D Human Recombinant proteins
Related genes to: IL-17D, Human Recombinant proteins
- Gene:
- IL17D NIH gene
- Name:
- interleukin 17D
- Previous symbol:
- -
- Synonyms:
- IL-22, IL-27, IL-17D, IL27, FLJ30846
- Chromosome:
- 13q12.11
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2018-09-10
Related products to: IL-17D, Human Recombinant proteins
Related articles to: IL-17D, Human Recombinant proteins
- The healing process of full-thickness skin wounds in maraena whitefish () was investigated to provide preliminary insights into the species' tissue regeneration mechanism and dynamics following mechanical injury-simulating standard aquaculture PIT tagging procedures. A mechanical skin injury was induced on the dorsal flank of one-year-old maraena whitefish using a 15G needle, and skin regeneration was tracked for 15 days post-wounding (dpw). Expression levels of six genes involved in immune response and inflammation ( and ), cellular stress response (), and cell proliferation and tissue growth (, , and ) were examined in wounded and intact skin tissues, liver, and head kidney. Histological analyses were also performed to monitor wound-healing progression. Histological examination revealed typical fish wound-healing characteristics involving re-epithelialization on the 1st day post-wounding (dpw), acute inflammation on the 3rd dpw, granulation tissue formation and intensive wound remodeling on the 8th dpw, and full tissue regeneration by the 15th dpw. Gene expression analysis revealed dynamic tissue-specific patterns: and were upregulated early in wounded skin, indicating rapid immune and inflammation activation, while and peaked later, supporting tissue remodeling and regeneration. and genes were highly expressed in the mid to late stage of healing, reflecting cellular stress response associated with acute inflammation and a high rate of cell proliferation in wounded skin. Significant transcriptional changes in the liver and head kidney further supported the systemic nature of the wound response and emphasized the importance of immune function in the species' tissue-repair process. The obtained findings provide novel insights into the mechanisms and dynamics of skin healing in maraena whitefish, potentially supporting the development of improved health management strategies for this species in aquaculture. - Source: PubMed
Publication date: 2025/08/27
Kuciński MarcinLiszewski TomaszWłasow TeresaWiśniewska AnnaFopp-Bayat Dorota - The airway epithelium plays a crucial role in maintaining lung homeostasis, and its dysregulation is often linked to various lung diseases, including asthma. Ciliated cells, abundantly present in the mammalian airway epithelium, have a critical function in clearing inhaled particles and pathogens. We show here that ciliated cells constitutively express IL-17D, which functions as an immune brake in limiting allergic inflammation in murine models of asthma. Mechanistically, IL-17D functions to prevent influx of classical monocytes into the lung and their subsequent conversion to pathogenic alveolar macrophages, through binding to CD93. Deficiency in Il17d or Cd93 increased the expression of chemokine receptors on classical monocytes, including CCR6, thereby enhancing their recruitment to the lung and type 2 inflammation. Our study thus reveals an unexpected protective role of ciliated cells and IL-17D in lung immune responses and asthma, which can be further explored for treating related diseases. - Source: PubMed
Publication date: 2025/08/05
Yuan LeiHuang JinlingChen JianhuiXie TianWang GenyuXie BowenQin LeiChen YongzhenZhong XuanZhao ZixuanPeng ZhilinWang XiaoshuangXu MiaoGe JingWang XiaohuDong Chen - The Tswana goat, a key component of Botswana's livestock, is renowned for its resilience and adaptability to low-resource environments. The objective of this study was to use homozygosity (ROH) and supplementary methods (F, iHS, xp-EHH, Rsb) to identify selection signatures and inbreeding pattern of the indigenous Tswana goat. A total of 216 goats were used, that is, Tswana (n = 114) from three agroecological regions in Botswana and Boer (n = 102), a reference population from South Africa. After quality control, 216 animals and 49 732 single-nucleotide polymorphisms were available for analysis. Tswana goats exhibited an average ROH length of 2.20 Mb and 85.71 ROH per goat, while Boer goats had longer, fewer ROH, averaging 155.96 Mb and 3.14 ROH per goat. Tswana goats had a lower inbreeding coefficient (F = 0.08) compared to Boer goats (F = 0.13). Significant ROH hotspots were found on chromosomes 12, 6, and 5 in Tswana goats and on chromosomes 24, 14, 9, 8, and 6 in Boer goats, with 27 annotated genes identified. Multiple selection signature detection methods detected genes such as PUS7L, ADAMTS20, TWF1, PRICKLE1 YAF2 and GXYLTI. Key genes associated with reproductive fitness (ATP12A, RNF17), immune response (IL17D, PARP4), coat colour variation (ADAMTS20), and milk synthesis (TWF1) were highlighted in Tswana goats, reflecting adaptive responses to environmental pressures. The study provides insights into the genetic adaptations and historical breeding of Tswana goat. This knowledge is crucial for implementing effective conservation strategies and enhancing the resilience of indigenous goat populations. By prioritising the genetic study of these goats, Botswana can ensure the sustainability of its unique livestock resources, promoting both food security and rural development in the region. - Source: PubMed
Publication date: 2025/07/02
Chalebgwa A BMonau P IRaphaka KHadebe KKgwatalala P MNsoso S J - To understand the genetic structure of local goat populations in Kazakhstan, we present the first comprehensive genomic analysis using a 70 K SNP array, examining 120 samples from six regions. The populations (Kundyzdy, Darbaza, Shokpar, Ushterek, Kenes and Kosseit) are named based on their breeding regions and are referred to ecotypes. Our results present a high genetic diversity, with observed heterozygosity (Ho) ranging from 0.389 to 0.444. Shokpar and Kundyzdy showed excess heterozygosity, while Kosseit and Darbaza had high inbreeding levels. Most populations recorded weak genetic differentiation, except for Ushterek goats, which were more distinct. For adaptability, Runs of Homozygosity (ROH) and Integrated Haplotype Score (iHS) identified 71 genes under selection, with gene ontology enrichment indicating localization as the most represented biological pathway important for cell response. Additionally, over 60% of these genes are co-expressed, suggesting their significant role in survival of these goats in their local environments. Some identified genes, such as NLRC4, HCLS1, IL17D, IL17RE, and IL17RC, were linked to immune response, an important adaptation trait in the context of climate change. This study not only emphasizes on high genetic variability of local goats in Kazakhstan but also lays the groundwork for developing conservation and breeding programs for local goats in Kazakhstan and other similar agroecological regions for adaptability and resilience under changing environmental conditions. - Source: PubMed
Publication date: 2025/06/02
Kichamu NellyWanjala GeorgeDossybayev KairatBagi ZoltánBekmanov BakhytzhanKusza Szilvia - Interleukin-17D (IL-17D) is a pro-inflammatory cytokine implicated in T helper 17 cell-mediated immune responses. Although its role in mammalian immunity is well established, its function in fish remains relatively unexplored. This study delves into the functional characteristics of IL-17D in chub mackerel (Scomber japonicus). We identified and characterized a chub mackerel IL-17D homolog (SjIL-17D) and investigated its spatial and temporal expression patterns, as well as the impact it has on downstream gene expression, apoptosis, cell proliferation, and nitric oxide (NO) production. SjIL-17D exhibited a wide tissue distribution, showing the highest expression in the blood, followed by the brain and skin. Upon immune challenges with polyinosinic:polycytidylic acid, lipopolysaccharide (LPS), Vibrio harveyi, and Streptococcus iniae, SjIL-17D expression was significantly upregulated in the blood. Functional analysis revealed that recombinant SjIL-17D (rSjIL-17D) stimulated the expression of pro-inflammatory cytokines, transcription factors, mitogen-activated protein kinases, and antiviral response genes in fish cell lines. Furthermore, rSjIL-17D attenuated LPS-induced apoptosis, promoted M1 macrophage polarization, and enhanced wound healing. Additionally, rSjIL-17D was found to stimulate NO production in macrophages and exhibit antiviral activity against viral hemorrhagic septicemia virus. These findings collectively demonstrate the crucial role that IL-17D plays in regulating immune responses in chub mackerel, providing valuable insights into the innate immune mechanisms of this economically important fish species. - Source: PubMed
Publication date: 2025/05/08
Jayasinghe J D H ETharanga E M TSirisena D M K PSandeepani R IKim GaeunKim JeongeunSohn HanchangWan QiangLee JihunLee Jehee