IL-17B, Human Recombinant proteins
- Known as:
- Interleukin-17B, Human Recombinant proteins
- Catalog number:
- 7106-50
- Product Quantity:
- 50 μg
- Category:
- Proteins
- Supplier:
- Biovis
- Gene target:
- IL-17B Human Recombinant proteins
Related genes to: IL-17B, Human Recombinant proteins
- Gene:
- IL17B NIH gene
- Name:
- interleukin 17B
- Previous symbol:
- -
- Synonyms:
- IL-17B, ZCYTO7, IL-20, MGC138900, MGC138901, NIRF
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 2000-01-20
- Date modifiied:
- 2016-10-05
- Gene:
- IL17RB NIH gene
- Name:
- interleukin 17 receptor B
- Previous symbol:
- IL17BR
- Synonyms:
- IL17RH1, EVI27, CRL4
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-18
- Date modifiied:
- 2015-08-25
Related products to: IL-17B, Human Recombinant proteins
Related articles to: IL-17B, Human Recombinant proteins
- The present study aimed to investigate the regulatory functions and mechanisms of human β-defensin 1 (hBD-1) in head and neck squamous cell carcinoma (HNSCC) through comprehensive bioinformatics analyses and experimental validation. Comprehensive bioinformatics analyses of TCGA database samples were performed, including DEFB1 expression profiling, clinical correlation analysis, prognostic evaluation, and pathway enrichment studies. The results demonstrated that DEFB1/hBD-1 expression was significantly downregulated in tumor tissues and negatively correlated with key genes in the IL-17 signaling pathway, while being associated with reduced lymph node metastasis and improved overall survival. Immunohistochemical validation confirmed low hBD-1 protein expression in HNSCC tissues. Assessment of hBD-1 expression across multiple HNSCC cell lines revealed consistently downregulated hBD-1 mRNA and protein levels. Functional experiments using stable hBD-1-overexpressing cell models demonstrated that hBD-1 overexpression significantly inhibited cell metabolic activity, clone formation, invasion, and migration while effectively inducing apoptosis. Mechanistic studies revealed that hBD-1 suppressed the IL-17B/IL-17RB/TRAF6/NF-κB signaling pathway by downregulating IL-17B and IL-17RB expression, inhibiting TRAF6 ubiquitination, and decreasing NF-κB pathway protein phosphorylation levels. In vivo xenograft experiments validated that hBD-1 overexpression significantly reduced tumor growth, volume, cell proliferation, and increased apoptosis. These findings collectively demonstrate that DEFB1/hBD-1 functions as a tumor suppressor in HNSCC through suppression of the IL-17B/IL-17RB/TRAF6/NF-κB axis, positioning it as a potential prognostic biomarker and therapeutic target for HNSCC management. - Source: PubMed
Publication date: 2025/09/03
Hu ShaonanLi SiminChen WenhaoDai GuangqinHuang XiuhongTian TaoRao YaxinNing WanchenDeng XinMujagund PrabhakarKreher DeborahSchmalz GerhardHuang ShaohongLiu Chufeng - Molecular farming using edible plants offers a cost-effective strategy for vaccine production because plants serve as both bioreactors and oral delivery systems. Owing to its rapid clonal propagation and high protein content, duckweed represents a promising platform for this purpose. Here, we developed an edible duckweed-based vaccine targeting avian infectious bronchitis virus (IBV), a highly contagious respiratory pathogen in poultry, and directly compared its efficacy to that of a commercial live-attenuated H120 vaccine. Transgenic duckweed expressing the IBV antigen peptide EpiC was orally administered to chickens, followed by immunological assessment and viral challenge. Without an adjuvant, the EpiC duckweed vaccine elicited robust systemic IgG and mucosal sIgA responses, conferring 100% protection against lethal IBV challenge - which is comparable to or exceeds the efficacy of the H120 vaccine. Strikingly, co-administration with duckweed expressing IL-17B as an adjuvant synergistically enhanced immune responses, including elevated IBV-specific IgGs in serum (P < 0.001), increased IBV-specific sIgAs in the trachea and kidney (P < 0.05), and reduced tracheal viral loads (P < 0.05). Transcriptomic analysis revealed the upregulation of B-cell receptors and enrichment of the IgA production pathway, indicating that sIgA-mediated mucosal immunity is a key protective mechanism. Histopathological analysis confirmed protection against IBV-induced tissue damage, whereas a reduced viral load in critical organs demonstrated systemic efficacy. By outperforming a licenced vaccine in head-to-head comparisons, this work highlights the readiness of duckweed for real-world adoption, offering transformative potential for combating mucosa-associated infections in the poultry industry and beyond. - Source: PubMed
Publication date: 2025/07/16
Tan XiaoGuo LingChen ShuangFang YangLiu PenghuiHu ZhubinJin YanlingYi ZhuolinHe KaizeLi XingZhao LeyiWang HongningZhao Hai - (FF), a widely used traditional Chinese medicine, possesses anti-inflammatory, antiviral, and anticancer properties. However, the precise anticancer mechanisms of FF against hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remain poorly understood. This study therefore aims to investigate the therapeutic potential of FF in HBV-related HCC and elucidate its underlying mechanisms. - Source: PubMed
Publication date: 2025/06/24
Chen FuqingCai YifanChen ChangzhouZhou Jianyin - IL-17RB is a cytokine receptor that binds interleukin (IL)-17B and IL-17E. While analyzing IL-17RB expression in various cancer cell lines, we found that this receptor is highly expressed at both the mRNA and protein levels in hepatocellular carcinoma (HCC) cells. This finding prompted us to investigate the effects of its ligand, IL-17B, on the proliferation of these cells. Our results demonstrate that IL-17B inhibits the proliferation of HCC cells through an AKT-dependent, but NF-κB-independent, mechanism. Additionally, IL-17B affected colony formation in these cells. Interestingly, these effects were not observed in melanoma cells, which express low levels of IL-17RB. Our results may represent a promising new approach for treating HCC - a disease for which immunological therapies have recently gained significant attention - especially considering that HCC patients experience progressive liver dysfunction and that the IL-17B-IL-17RB signaling pathway plays a role in liver regeneration. - Source: PubMed
Publication date: 2025/06/17
Pastwińska JoannaKarwaciak IwonaKaraś KajaGrabarczyk DariaSałkowska AnnaRatajewski Marcin - Subacute rumen acidosis (SARA) is a common metabolic disorder in ruminants that disrupts the rumen microbiome and animal health, but diagnosis is challenging due to subtle symptoms and invasive testing requirements. This study explores the potential of the buccal (oral) microbiome as a diagnostic indicator for SARA, hypothesizing an interaction with the rumen microbiome. - Source: PubMed
Publication date: 2025/03/02
Liu TaoXu JingyiChen XiaodongRen JianrongHe JinhuiWang YueCao YangchunGuan Le LuoYao JunhuWu Shengru