EZSolution™ AICAR
- Known as:
- EZSolution™ AICAR
- Catalog number:
- 2344-50
- Product Quantity:
- 50 mg
- Category:
- -
- Supplier:
- Biovis
- Gene target:
- EZSolution™ AICAR
Related genes to: EZSolution™ AICAR
- Gene:
- ATIC NIH gene
- Name:
- 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
- Previous symbol:
- -
- Synonyms:
- PURH, AICARFT, IMPCHASE
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1997-05-15
- Date modifiied:
- 2014-11-19
Related products to: EZSolution™ AICAR
Related articles to: EZSolution™ AICAR
- Many physical systems involve two types of orientational order, which are coupled together. For example, ferroelectric nematic liquid crystals have coupled polar and nematic order, and tilted hexatic phases have coupled polar and hexatic order. In these systems, defect structures can be quite complex. Here, we investigate phases with two types of two-dimensional orientational order, -atic and -atic, where and are two distinct integers. We simulate these phases in a flat disk with strong radial anchoring, and on a spherical surface, because both of these geometries require the presence of defects. If the coupling between the two types of order is weak, then the defects are connected by a network of diffuse walls, and the system forms a stable domain structure. As the coupling increases, the domain walls become sharper and shorter. For very strong coupling, the higher-order defects merge into the lower-order defects, forming stretched defect cores. - Source: PubMed
Publication date: 2026/06/05
Paik LincolnSelinger Jonathan V - Autophagy plays a non-negligible role in the progression and immune regulation of hepatocellular carcinoma (HCC). An integrated analysis of the autophagy-related genes (ARGs) is of significance to deepen our mechanistic understanding about HCC pathology. In our present work, based on the expression patterns of 221 ARGs, we first identified 2 autophagy-related subtypes for TCGA-HCC patients using consensus clustering method. The two subtypes showed considerable distinctions in terms of molecular characteristics, immune landscapes and clinical outcomes. To augment the clinical utility of the subtyping system, a four-gene prognostic model including ATIC, RHEB, TMEM74 and PRKCD was developed and verified through LASSO and multivariate Cox regression analyses. ROC(AUC) analysis confirmed the predictive efficacy of the model across the training and validation cohorts. Notably, HCC patients in the high-risk group exhibited elevated tumor mutation burdens and higher expression of multiple immune checkpoint genes, suggesting distinct immune-related features between risk groups. Furthermore, single-cell RNA sequencing analysis revealed that the model's marker gene-ATIC was predominantly expressed in tumor cells and proliferative T cells, with its expression showing strong and positive associations with autophagy activity. Finally, in vitro experiments were conducted to explore the potential role of ATIC in HCC. The results indicated that ATIC knockdown was associated with reduced proliferative and migratory capacities of HCC cells, along with alterations in autophagy-related phenotypes, including decreased autophagic flux. Taken together, our study provides a preliminary autophagy-related prognostic signature and identifies ATIC as a potential regulator of HCC progression. - Source: PubMed
Publication date: 2026/06/08
Xie LonghuiWang TiantianPan ChangbinLan JianweiYang YangLv LijuanZhou CilaQin ShuangNing Yinkuan - Telescopic intramedullary nailing is a cornerstone in the surgical management of pediatric osteogenesis imperfecta (OI), providing fracture prevention and deformity correction while accommodating bone growth. Nevertheless, implant-related complications remain a challenge affecting long-term outcomes. - Source: PubMed
Publication date: 2026/05/29
Sayar SafakAlemdar CelilAtic RamazanDemir SebahattinAydin AbdulkadirYalvac Eyyup Serdar - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/ IMP cyclohydrolase(ATIC) is a 64-kDa bifunctional enzyme, 5-aminoimidazole- 4-carboxamide ribonucleotide formyltransferase (AICART) and IMP cyclohydrolase, respectively. catalyzes the last two steps of the purine ab initio biosynthetic pathway. ATIC has been implicated in cancer progression, but its pan-cancer profile and specific prognostic utility in liver hepatocellular carcinoma (LIHC) remain incompletely defined. - Source: PubMed
Publication date: 2026/05/11
Li HuiZhang WentaoZhou XiaojieWu WeimingYao FuwenZhong HaojieZhan NaiyangChen JianWeiZhan YongqiangYang Xinping - Proximal extra-articular tibial fractures present considerable biomechanical and technical challenges due to the short proximal fragment, the wide metaphyseal canal, and the deforming forces acting around the knee. These factors predispose isolated intramedullary (IM) nailing to malalignment, prompting the use of adjunct reduction aids such as Poller screws or supplemental plates. This study aimed to compare the mechanical behavior of IM nailing alone with that augmented by Poller screws or a monocortical plate in a standardized proximal tibia fracture model. - Source: PubMed
Publication date: 2026/05/18
Şahin Mehmet AkifDurgut FatihYiğit ŞeyhmusAkar Mehmet SaitÖzkul EminAtiç RamazanÇiftçi Sadettin