Porcine NEFL (Neurofilament, Light Polypeptide) ELISA Kit
- Known as:
- Porcine NEFL (Neurofilament, Light Polypeptide) Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- E-EL-P2020
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- Elabscience
- Gene target:
- Porcine NEFL (Neurofilament Light Polypeptide) ELISA Kit
Related genes to: Porcine NEFL (Neurofilament, Light Polypeptide) ELISA Kit
- Gene:
- NEFL NIH gene
- Name:
- neurofilament light
- Previous symbol:
- -
- Synonyms:
- NFL, CMT1F, CMT2E, NF68, PPP1R110
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: Porcine NEFL (Neurofilament, Light Polypeptide) ELISA Kit
Related articles to: Porcine NEFL (Neurofilament, Light Polypeptide) ELISA Kit
- Diagnosis of Alzheimer's disease (AD) relies on invasive cerebrospinal fluid analysis or costly neuroimaging, underscoring the need for minimally invasive blood-based biomarkers for early detection. Exosomes, promising biomarker carriers, are unexplored for ultra-short RNA species like abortive transcripts (ATs). We investigated whether 8-nucleotide ATs are selectively packaged into exosomes to reflect brain transcriptional dysregulation in AD. Using a transgenic AD mouse model and Aβ-stimulated BV2 microglia coupled with Base-Stacking Hybridization Assisted Ligation (BSHAL), we detected significant dysregulation of ATs from AD-relevant genes (Nefl, Bace1, Tyrobp, Ccl2, Pf4) in brain tissue; specifically, Bace1, Tyrobp, and Pf4 ATs showed robust increases (2.21-fold to 17.50-fold). These dysregulated AT signatures were mirrored in peripheral blood exosomes: Bace1, Tyrobp, and Pf4 ATs increased 10.58-, 38.72-, and 11.63-fold, respectively. Aβ-activated microglia demonstrated exosome-specific enrichment of ATs, particularly Pf4 ATs (~3510-fold increase), confirming active exosomal packaging. Exosomal ATs confer cell-type specificity for central nervous system pathology, lipid bilayer-enhanced stability, and sensitivity to transcriptional changes preceding pathological aggregation. Our findings, obtained in a transgenic mouse model and an in vitro microglial system, establish exosomal ATs as a novel class of blood-based biomarkers with potential for early AD diagnosis, pending validation in human cohorts. - Source: PubMed
Publication date: 2026/09/11
Wu HaizhuZhang NaYan WeiweiLi CailinZhang XiaomeiXv XianglinFang FangQin ShaoweiZhao Lifeng - Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) are the two leading causes of cognitive impairment in the elderly, with overlapping clinical manifestations. This study aimed to explore the expression differences of plasma Aβ1-42, Aβ1-40, Aβ1-42/Aβ1-40, p-Tau181, p-Tau217, NfL and GFAP among patients with AD, CSVD and healthy populations, and to evaluate the diagnostic value of these biomarkers for AD as well as the differential diagnostic efficacy between AD and CSVD. - Source: PubMed
Publication date: 2026/08/27
Xiandong WangJunqi WuXuan ZhangDaichao MaXiaoyan ZhaoLihua HeHui Zhang - Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM). Neurofilament light chain (NfL) is a circulating marker of neuroaxonal injury, but its interpretation may be influenced by age and renal function. - Source: PubMed
Publication date: 2026/09/09
Škorvanová MichaelaVerešpejová Andrea IžarikHanes JozefPlášil RadovanHuňarová NatáliaŠofranko JakubChien Li-ShengKolísek Martin - This study investigated the predictive value of neurofilament light chain (NfL) levels beyond MRI measures of disease activity in multiple sclerosis (MS). - Source: PubMed
Publication date: 2026/09/09
Mattiesing Rozemarijn MGentile GiordanoBattaglini MarcoDe Stefano NicolaBrouwer ImanStrijbis Eva M MUitdehaag Bernard M JBarkhof FrederikVrenken HugoSchoonheim Menno M - Transient Ischemic Attack (TIA) may induce subtle tissue damage that remains undetectable on conventional magnetic resonance imaging (MRI), which has led to growing interest in blood biomarkers of neuronal and glial injury. This study examined whether plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) can distinguish patients with clinically defined, MRI-negative TIA from healthy individuals. - Source: PubMed
Publication date: 2026/09/08
Berinato FrancescoMorotti AndreaBaronchelli GiovanniTolassi ChiaraGirotto IrenePilotto AndreaPadovani Alessandro