IL-7 recombinant protein
- Known as:
- Interleukin-7 Rec. protein
- Catalog number:
- BRP1051
- Product Quantity:
- 100 μg
- Category:
- -
- Supplier:
- Biospect
- Gene target:
- IL-7 recombinant protein
Related genes to: IL-7 recombinant protein
- Gene:
- IL7 NIH gene
- Name:
- interleukin 7
- Previous symbol:
- -
- Synonyms:
- IL-7
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-12
- Date modifiied:
- 2016-10-11
- Gene:
- IL7R NIH gene
- Name:
- interleukin 7 receptor
- Previous symbol:
- -
- Synonyms:
- CD127, IL7RA
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2019-04-23
Related products to: IL-7 recombinant protein
Related articles to: IL-7 recombinant protein
- Autoimmune hepatitis (AIH) is an uncommon condition among persons living with HIV (PLWH), and its clinical presentation may be influences by immune reconstitution and viral reactivation, potentially affecting disease course and prognosis. In this retrospective case series, we aimed to describe the clinical features, pathological findings, treatment approaches, and outcomes of PLWH diagnosed with AIH in Yunnan Province, China, with a focus on region-specific clinical features. - Source: PubMed
Publication date: 2026/06/15
Wang DanqingLiu JiafaLin SenZhou QiwenZhang MiLiao AimeiYu XingwenDong XingqiMin HaiyanYang Xinyi - The ovary is an immunologically dynamic tissue that coordinates recurrent inflammation-like remodeling while preserving local T cell tolerance, yet whether it actively instructs infiltrating lymphocyte phenotype or passively enriches pre-existing subsets has not been directly tested. To address this, we used peripheral double-negative T cells (DNTs; CD3CD4CD8NK1.1) as a coreceptor-null system to detect tissue-imposed phenotypic change after ovarian entry. Using adoptive transfer, labeled splenic DNTs accumulated in the ovary relative to other tissue sites, and donor DNTs acquired surface CD8 expression within 4 days of ovarian localization. Dissociated ovarian cells were sufficient to drive CD8 upregulation on sorted DNTs in vitro, supporting that ovarian cellular cues can promote this response. Ovarian single-cell RNA-seq provided supportive evidence for Il7-expressing stromal subsets, and an Il7r-enriched DNT-associated lymphoid population, findings compatible with local IL-7-associated microenvironmental cues that may contribute to conditioning infiltrating T cells. Functionally, IL-7R was required for efficient CD8 upregulation after ovarian localization, and IL-7R or IL-7 deficiency shifted the endogenous ovarian DNT: CD8 T cell balance. These findings support the ovary as an immune-conditioning environment in which tissue entry is associated with CD8 coreceptor induction on peripheral DNTs, and identify IL-7R signaling as a requirement for efficient induction in this setting. - Source: PubMed
Publication date: 2026/06/16
Martin ToniYoung Howard ABafor Enitome E - CAR-T cell therapy has achieved remarkable success in the treatment of certain blood cancers, but its efficacy against solid tumors remains limited. One of the key strategies is the improvement of manufacturing methods for the rapid production of high-functioning CAR-T cells. We have improved the manufacturing method for CAR-T cells simultaneously expressing IL-7 and CCL19 (referred to as 7×19 CAR-T cells), armored CAR-T cells which we developed for treating solid tumors. We generated 7×19 CAR-T cells using a short-term culture method without expansion phase (referred to as Swift 7×19 CAR-T cells), then compared them with regular culture methods (referred to as Standard 7×19 CAR-T cells). Swift CAR-T cells are distinguished by a high frequency of early memory phenotypes, including stem cell memory and central memory T cells, which showed superior effector functions over Standard CAR-T cells. In a stress test in which effector cells are repeatedly stimulated by target-positive tumor cells, Swift 7×19 CAR-T cells and Swift conventional CAR-T cells initially exhibited similar antitumor effects. However, after repetitive stimulations, only Swift 7×19 CAR-T cells maintained a robust response. Furthermore, Swift 7×19 CAR-T cells demonstrated in vivo antitumor activity by substantially fewer cells compared to Standard 7×19 CAR-T cells, and conferred a long-term resistance to tumor rechallenge without autonomous proliferation indicative of malignant transformation. These results highlight the potential of the innovative "Swift" short-term culture methods combined with 7×19 CAR-T technology to provide a new treatment option for refractory solid tumors. - Source: PubMed
Publication date: 2026/06/15
Sakai KoheiSakoda YukimiAdachi KeishiOhta YasuharuTamada Koji - Although autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) show significant clinical overlap, it remains unclear whether they share a common basis of immune dysregulation. To characterize the shared and distinct immune dysregulation, we performed a network meta-analysis (NMA) to compare inflammatory profiles across ASD, ADHD, and healthy controls (HC). We systematically searched PubMed, Web of Science, and Embase for literature published up to January 1, 2025. For each inflammatory marker, NMA was conducted when studies for both ADHD and ASD were available; otherwise, pairwise meta-analyses were used. Additionally, meta-regression analysis was employed to assess the influence of age and sex. Seventy-four studies were included (participants: ASD: 4331, ADHD: 990, HC: 5037). NMA showed that, compared with controls, individuals with ASD had higher levels of CRP, IL-6, IL-8, IL-1β, and BDNF, whereas individuals with ADHD had lower levels of TNF-α, IL-2, and MCP-1. Individuals with ASD had higher levels of TNF-α, IL-2, IL-8, IL-1β, and MCP-1 compared to those with ADHD. Pairwise meta-analysis revealed elevated levels of IL-4, IL-7, IL-12, IL-1α, MIP-1β, eotaxin, and GM-CSF in ASD, while no significant differences were observed between ADHD and controls. Pairwise meta-regression suggested that certain inflammatory markers may be influenced by age and sex. This first NMA suggests distinct immune dysregulation patterns: individuals with ASD exhibit alterations across multiple inflammatory cytokines, whereas individuals with ADHD show decreased levels of specific inflammatory factors. Future large-scale studies are needed to validate these biomarkers. - Source: PubMed
Publication date: 2026/06/13
Chen QiuxingSun YuqiPan NanfangLong YajingCao YingLuo YaXin KaiqiChen PinqiWang YingjinShu MinChen YingGong Qiyong - Autoimmune encephalitis (AE) is a major cause of acute and subacute neuropsychiatric syndromes. - Source: PubMed
Publication date: 2026/06/09
Srivastava ArpnaSingh Rajesh KumarBanerjee JyotirmoyA ElavarasiDas AnimeshRamanujam BhargaviParihar JasminePandit Awadh KishorV Y VishnuVibha DeeptiChandra SaratSrivastava M V PadmaTripathi Manjari