Mouse CXCL16 ELISA kit
- Known as:
- Mouse CXCL16 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- BEK1038
- Product Quantity:
- 96 T
- Category:
- Elisa Kits
- Supplier:
- Biospect
- Gene target:
- Mouse CXCL16 ELISA kit
Related genes to: Mouse CXCL16 ELISA kit
- Gene:
- CXCL16 NIH gene
- Name:
- C-X-C motif chemokine ligand 16
- Previous symbol:
- -
- Synonyms:
- SR-PSOX, CXCLG16, SRPSOX
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-21
- Date modifiied:
- 2016-10-05
Related products to: Mouse CXCL16 ELISA kit
Related articles to: Mouse CXCL16 ELISA kit
- Kupffer cells (KCs) are key drivers of immune homeostasis following liver transplantation (LT). We identified a specialized APOE KC subset enriched in stable and tolerant grafts by integrating human single-cell RNA sequencing with murine orthotopic LT models. These APOE KCs function as a central signaling hub, communicating with CD8 tissue-resident memory (TRM) T cells via the CXCL16-CXCR6 axis. Using APOE-knockout models, we demonstrated that donor-derived APOE was essential for KC suppressive capacity. APOE deficiency exacerbates acute rejection by preventing CD8 TRM cells from upregulating inhibitory checkpoints (PD-1 and TIGIT) and from transitioning into an exhausted state, which is necessary to resolve alloreactivity. Clinically, elevated donor serum APOE inversely correlates with recipient model for end-stage liver disease (MELD) scores and liver injury. Ultimately, APOE KCs promote graft tolerance by driving CD8 TRM exhaustion, establishing donor APOE as a critical prognostic biomarker and dual therapeutic target for optimizing transplant survival. - Source: PubMed
Publication date: 2026/09/09
Jia ZhuoyuLi XinqiangWang XuetengZhou XinCai HailunJiang PengDing RuidongLiu HuanWang YeLi ShipengCai Jinzhen - is a major human pathogen that can elicit immune-inflammatory responses and infections, largely driven by its broad repertoire of antigenic proteins. Understanding these factors is valuable for elucidating mechanisms of infection. - Source: PubMed
Publication date: 2026/09/02
Dalloul Rajaa S DSohail Muhammad UChennakkandathil SareenaSawarth HinaAl-Noubi MunaChoi SunkyuSchmidt Frank - Multiple sclerosis (MS), an immune-mediated neuroinflammatory disease, is characterized by demyelination, axonal injury and extensive destruction of the integrity of the central nervous system. Experimental autoimmune encephalomyelitis (EAE) is the most commonly used model for simulating the pathological features of human MS. Presently, there is still much room for improvement in the treatment strategy of MS. More and more studies have shown that traditional Chinese medicine (TCM) and related active metabolites are beneficial to the treatment of MS, and skillfully regulate the levels of inflammatory factors and immune system imbalance. Focusing on the core pathological mechanisms of MS, this review elucidates the beneficial effects of TCM in the prevention and treatment of MS the modulation of autoimmune responses and inflammation-associated signaling pathways, as well as the underlying mechanisms of action. The main keywords "multiple sclerosis", "experimental autoimmune encephalomyelitis", "traditional Chinese medicine", "natural metabolites", "bioactive metabolites", "autoimmune", "inflammatory signals" and other details were retrieved from PubMed and Web of Science, Scopus, ScienceDirect, and Google Scholar. The results indicate that TCM preparations, including botanical drugs, active metabolite monomers and formulas, exert neuroimmunomodulatory effects modulating Th1/Th2 and Th17/Treg cell balance and the CXCR6/CXCL16 signaling axis, and consequently inhibit excessive immune activation. Additionally, it regulates a variety of inflammation related signaling pathways, including NLRP3, TLR4/MyD88/NF-κB, MAPK, PI3K/Akt and JAK/STAT signal pathways, thus contributing to the treatment of MS. This study deepens our understanding of the mechanisms of TCM intervention in MS, and opens up a new perspective for clarifying the clinical value and development prospect of TCM in the treatment of MS. - Source: PubMed
Publication date: 2026/09/01
Qian DieLi XiaohongGe JingjingLiu ShuaiNa MingminHuang MaokuiMo QingyanJu MingqianWan Chunping - The bone is the primary site of distant metastasis in patients with nasopharyngeal carcinoma (NPC), and bone metastasis (BM) significantly increases mortality. Deciphering the complex crosstalk between cancer cells and their tumor microenvironment (TME) is crucial for identifying therapeutic targets aimed at eliminating metastasis-initiating cells and preventing the establishment of overt metastases. Regulatory B cells (Bregs), a specialized B-cell subset endowed with potent immunosuppressive functions, play a pivotal regulatory role within the TME. However, their specific contributions, phenotypic characteristics, and underlying molecular mechanisms within the BM niche of NPC remain incompletely characterized and await full elucidation. This study aims to investigate the infiltration dynamics, functional impact, and molecular underpinnings of Bregs in the context of NPC BM. - Source: PubMed
Publication date: 2026/08/27
Yang KaifanZhang JinyeMao XinyuanChen XintongHuang JiandangXie KainanLin XiaoyiZhou XinYu BinZhao LiangLin Yanling - The meninges form the border between the brain and periphery and house a rich network of immune cells. Here we show that gastrointestinal challenges (intracellular or extracellular bacteria and parasites) reshape the nature of CD4 T cells in the dura mater, the outer meningeal layer, changing the dominant polarization states to T helper (T) 1, T17 and T2 cells, respectively, with differing cytokine profiles. This occurs via CXCR6-CXCL16-dependent migration of gut-activated CD4 T cells to the central nervous system, where they establish long-lived memory populations around the dural venous sinuses, within dural lymphoid aggregates and in the brain. Functionally, these orally primed dural CD4 T were capable of rapid, antigen-specific recall responses, proliferating and producing cytokines upon intravenous rechallenge. Our findings reveal a direct link between intestinal and dural immunity, enabling the central nervous system borders to acquire immunological memory of gut microorganisms, a major source of bloodborne pathogens capable of reaching the brain via fenestrated dural vasculature. - Source: PubMed
Publication date: 2026/09/08
Fleming AaronNeish KarenDi Marco-Barros RafaelPosner David ALee Colin Y CStewart AndrewTuong Zewen KelvinBremridge MilesPeñalver AnaCabantous MiaRichoz NathanPortet AnaisHarcourt KatherineGillman EleanorSow Tammie Tao MinHasegawa TetsuoRuano-Gallego DavidFrankel GadWithers DavidClare SimonClatworthy Menna R