Cytokeratin 19, CK19 recombinant protein
- Known as:
- Cytokeratin 19, CK19 Rec. protein
- Catalog number:
- BRP1007
- Product Quantity:
- 100 μg
- Category:
- -
- Supplier:
- Biospect
- Gene target:
- Cytokeratin 19 CK19 recombinant protein
Related genes to: Cytokeratin 19, CK19 recombinant protein
- Gene:
- KRT19 NIH gene
- Name:
- keratin 19
- Previous symbol:
- -
- Synonyms:
- K19, CK19, K1CS, MGC15366
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-11
- Date modifiied:
- 2016-03-09
Related products to: Cytokeratin 19, CK19 recombinant protein
Related articles to: Cytokeratin 19, CK19 recombinant protein
- Preeclampsia (PE) is a serious complication of pregnancy for which reliable early predictive biomarkers are currently lacking. Cell-free RNA (cfRNA) has emerged as a promising non-invasive approach that may enhance clinical management and facilitate earlier diagnosis. - Source: PubMed
Publication date: 2026/08/17
Chen YinlongZhan WenliShen KeChen ZhiZheng Qingliang - Colorectal cancer (CRC) remains a leading cause of cancer mortality globally, with therapeutic efficacy hindered by tumor heterogeneity and drug resistance. While organoid technology offers unprecedented opportunities to model tumor complexity, systematic platforms for chemo-targeted combination screening and molecular mechanisms underlying chemoresistance remain underexplored in Chinese populations. Here, we established a biobank of 17 patient-derived CRC organoids (85% success rate) from treatment-naïve surgical specimens, preserving histopathological fidelity and molecular diversity of parental tumors. High-throughput drug screening across eight clinical regimens revealed different responses. To dissect chemoresistance mechanisms, six organoids representing extreme phenotypes (three sensitive and three resistant, based on IC50 difference for irinotecan + raltitrexed) were selected from this cohort for single-cell transcriptomic analysis. Single-cell transcriptomics of irinotecan + raltitrexed-treated organoids identified chemoresistance-associated clonal expansion of epithelial subpopulations (cluster_0), characterized by overexpression of REG4/TFF1/TFF3 and epithelial keratins (KRT19/KRT8/KRT18). Intercellular network analysis revealed intra-epithelial communication as a resistance hub, mediated by 32 ligand-receptor pairs. Integration with TCGA-COAD cohort (n = 378) demonstrated intratumoral heterogeneity (ITH) score as an independent prognostic determinant, outperforming stemness/angiogenesis metrics. Machine learning consensus identified CEACAM6 and KRT19 as dual regulators of mortality and ITH through epithelial plasticity networks. Our multi-omics framework establishes organoid-guided chemoresistance mechanisms while proposing ITH quantification targeting as precision strategies. This study bridges critical gaps in CRC therapeutic personalization, offering clinically actionable insights for overcoming treatment failure. - Source: PubMed
Jing ChangwenWang ZhuoCao HaixiaZhang YuanHuang YuchunYu YuetongLi BingzheMa Rong - In adult females of most hystricomorph rodents (animals in the suborder Hystricomorpha, such as guinea pigs), the vagina is open only during heat period; for the remainder of the estrous cycle, it is occluded by a structure resembling the human hymen-known as the "vaginal closure membrane" (VCM). This process of periodic formation and regression of the VCM persists throughout the animal's entire life, from puberty until death. To date, the underlying mechanisms explaining why only this small subset of rodents periodically forms a VCM remain largely unelucidated. In this study, we compared the epithelium structure around the external vaginal orifice between guinea pigs and mice, revealed that a hairless epidermal transition zone exists in guinea pig but not mice. The proliferation of keratin (Krt) 10-positive epithelial cells in this zone plays key roles in VCM formation. Hormone treatment in ovariectomized guinea pigs revealed progesterone may promote the formation and thickening of VCM. Ki67 cytoplasmic localization and strong expression of progenitor cell marker Krt19 in epithelial cells at external vaginal orifice of guinea pigs but not mice indicated that the VCM formation in guinea pigs is most likely a tissue remodeling process. And in addition, we identified a novel population of stem cells expressing pluripotency markers at the external vaginal orifice of guinea pigs. Our findings suggest that, in guinea pigs, pluripotent stem cells may reside within the epithelial tissue of the vaginal opening region of adult females and is responsible for VCM formation. - Source: PubMed
Publication date: 2026/07/20
Wang ShanshanZheng Zhengui - Human induced pluripotent stem cell (iPSC)-derived neural cells (NCs) and cardiomyocytes (CMs) show significant promise for clinical applications in regenerative medicine. Because the manufacturing of iPSC-derived products faces challenges in quality reproducibility, cost, and manufacturing time, closed automated culture systems have been developed. Recently, an efficient and noninvasive cell monitoring system based on extracellular markers secreted by cells represents a new strategy for closed systems. Extracellular vesicles (EVs), secreted by cells, contain proteins involved in stem cell differentiation; however, EV proteins in the cell culture medium are difficult to analyze because of their low abundance. Thus, their changes during cell differentiation, and the relationship between EV and cell proteins, remain unclear. In this study, we investigated the changes in EV proteins during iPSC differentiation into NCs and CMs using data-independent acquisition LC/MS/MS (DIA-MS), a highly comprehensive and quantitative approach. We observed significant positive correlations between the EV protein abundance and cellular protein expression levels during differentiation on days 0-7, and identified signature proteins characteristic of NCs and CMs. Among these, trophoblast glycoprotein (TPBG) for NC differentiation and keratin, type I cytoskeletal 19 (KRT19) for CM differentiation were particularly increased in both cells and EVs. Moreover, TPBG and KRT19 levels at day 7 showed similar trends to the differences in differentiation observed among the cell lines, as determined by flow cytometry. These findings suggest that these EV proteins may serve as predictive markers for monitoring differentiation into NC and CM. - Source: PubMed
Publication date: 2026/07/17
Mikami MeiKatsuno EriHoshina ShunsukeTakashita KanseiTakakura DaisukeKawasaki Nana - Ovarian steroid cell tumors-not otherwise specified (SCT-NOS) is a rare category of sex cord-stromal tumor, however, its pathophysiology is unclear. A comprehensive cellular atlas of ovarian SCT-NOS remains lacking. - Source: PubMed
Publication date: 2026/07/17
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