C-REACTIVE PROTEIN (CRP), Rhesus Monkey Liquid
- Known as:
- C-REACTIVE PROTEIN (CRP), Rhesus Monkey Liquid
- Catalog number:
- 144-13
- Product Quantity:
- 250 ug
- Category:
- -
- Supplier:
- LeeBio
- Gene target:
- C-REACTIVE PROTEIN (CRP) Rhesus Monkey Liquid
Related genes to: C-REACTIVE PROTEIN (CRP), Rhesus Monkey Liquid
- Gene:
- ABCG2 NIH gene
- Name:
- ATP binding cassette subfamily G member 2 (Junior blood group)
- Previous symbol:
- -
- Synonyms:
- EST157481, MXR, BCRP, ABCP, CD338
- Chromosome:
- 4q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2019-04-23
- Gene:
- ADIPOQ NIH gene
- Name:
- adiponectin, C1Q and collagen domain containing
- Previous symbol:
- ACDC
- Synonyms:
- ACRP30, AdipoQ, apM1, GBP28, adiponectin
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-26
- Date modifiied:
- 2016-10-05
- Gene:
- BANF1P1 NIH gene
- Name:
- barrier to autointegration factor 1 pseudogene 1
- Previous symbol:
- -
- Synonyms:
- BCRP1, D14S1460, D14S1460E, BCRG1
- Chromosome:
- 14q24.1
- Locus Type:
- pseudogene
- Date approved:
- 2003-04-09
- Date modifiied:
- 2012-04-19
- Gene:
- C1QTNF4 NIH gene
- Name:
- C1q and TNF related 4
- Previous symbol:
- -
- Synonyms:
- CTRP4, ZACRP4
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
- Gene:
- C1QTNF6 NIH gene
- Name:
- C1q and TNF related 6
- Previous symbol:
- -
- Synonyms:
- CTRP6, ZACRP6
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
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- Plumage colour in domestic geese is an important economic trait and a selection target since the early days of domestication. In European domestic geese of greylag goose (Anser anser) origin, white plumage is known to be determined by two independent loci, one causing white spotting and another sex-linked dilution, together producing white plumage. Strong candidate genetic variants have been identified upstream of the EDNRB2, that is, LOC106047519 gene (endothelin receptor B-like) and within the sex-linked MLANA gene (melan-A). To confirm these candidate variants, we genotyped differently coloured European domestic goose breeds, wild greylag geese, Chinese domestic geese (derived from swan goose A. cygnoid) and European and Chinese domestic geese crossbreeds. One base pair deletion in the MLANA gene (NW_013185876.1: g.950868 C>-) was confirmed to cause sex-linked dilution, and thus autosexing (almost white gander and diluted grey goose). However, a genetic variant upstream of EDNRB2 (NW_013185915.1: g.775151 G>T) was not causative of saddleback pattern but strongly linked to it in European domestic geese. We sequenced the EDNRB2 gene and coding sequence of a neighbouring VAMP7 gene (vesicle-associated membrane protein 7) but found no genetic variation linked to colour. Additionally, we sequenced the coding sequence of TYRP1 (tyrosinase related protein 1), a candidate gene for buff colouration, but no variation linked to colour was found. Further, we genotyped a 14-bp insertion in exon 3 of the EDNRB2 gene, known to be causative of the white phenotype in the Chinese domestic goose, and identified it in one European domestic goose. - Source: PubMed
Olli SuviAhola VikkeHeikkinen Marja EHonka Johanna - The molecular diagnosis of albinism is hampered by a significant number of genetic variants of unknown significance (VUS) including a majority of missense and in-frame insertion deletion variants. This contributes to the high rate of unresolved genetic diagnosis for this disease. We designed a straightforward test of missense VUS in albinism genes based on functional rescue. As a proof of concept, the assay was set up for testing variants in the gene associated with oculocutaneous albinism type 1. The gene was knocked-out in the human melanogenic MNT1 cell line and the resulting unpigmented clones used as host cells for rescue experiments. Selected VUS and control sequences were run through the assay. Expression of tyrosinase was quantified by Western blot, melanin synthesis was evaluated by direct observation as well as absorbance monitoring. One VUS, p.Ser270Phe (S270F) can be classified as likely pathogenic as it fails to restore pigmentation, whereas rescue was achieved with D305E and A391T. The two most frequent missense VUS of , S192Y and R402Q, were also tested independently or in combination confirming the pathogenic effect of their association in . All in all, this new assay is a proof of concept and can be considered for testing variants in other albinism genes such as and . - Source: PubMed
Publication date: 2026/06/19
Mercier ElinaMichaud VincentSequeira AngèleArveiler BenoitJaverzat Sophie - Liancheng white ducks have a distinctive "white feathers, black beak, and green feet" phenotype, making them a useful model for studying pigmentation traits in waterfowl. The previous study found that the F1 generation of Liancheng white ducks crossed with white-feathered ducks and hemp-feathered ducks were all gray-black in color. This indicates the specificity and complexity of melanin deposition in Liancheng white ducks, which makes the selection and breeding of pigment traits through phenotyping difficult. The aim of this study was to investigate the candidate transcriptomic regulatory signals of melanogenesis in Liancheng white ducks. Skin, mouth skin, foot skin, liver, and muscle samples were collected from 130-day-old Liancheng white ducks. Morphological differences were observed via histological analysis, and extraction-based pigment levels were determined. The results showed that melanin granules were clearly observed in tissues other than the liver and were distributed mainly in the basal layer of the epidermis and around feather follicles; the pigment values in the tissues decreased in the order mouth skin > liver > foot skin > muscle and skin. However, the relatively high liver value should be interpreted cautiously because obvious melanin granule deposition was not observed histologically. Whole-transcriptome sequencing was performed on mouth skin and skin samples. In total, 3074 differentially expressed genes (DEGs) were screened; upregulated genes associated with melanogenesis included melanocyte inducing transcription factor (MITF) and tyrosinase (TYR); downregulated genes included agouti signaling protein (ASIP) and adenylate cyclase 2 (ADCY2). Eighteen differentially expressed microRNAs (DEmiRNAs) were identified. Based on target prediction and pathway enrichment analysis, novel_290 and apl-miR-11588-3p were identified as candidate miRNAs potentially associated with melanogenesis-related pathways, and their predicted target genes included phosphatidylinositol 3-kinase (PI3K) and Janus kinase 1 (JAK1). Additionally, 364 differentially expressed long noncoding RNAs (DElncRNAs) were identified; TCONS_00063335 and TCONS_00019814 were identified as candidate lncRNAs potentially associated with melanogenesis-related genes, including TYR and TYRP1. A putative ceRNA network was constructed based on the predicted miRNA-mRNA and miRNA-lncRNA relationships, and ENSAPLT00000025522-apl-miR-11588-3p-MAPK8IP3 was identified as a candidate network relationship associated with MAPK-related pigmentation pathways. However, because this relationship was inferred mainly from bioinformatic prediction and expression association analysis, further functional validation is required to confirm whether it contributes to melanogenesis regulation. These findings provide candidate transcriptomic and noncoding RNA information for the further investigation of tissue-specific pigmentation in Liancheng white ducks. - Source: PubMed
Publication date: 2026/06/18
Shi WenliLi LiZhao BangzheCai QiannanLiu XiaopanZhu ZhimingZhang LinliMiao ZhongweiHuang QinlouZheng NenzhuXin Qingwu - Jiangshan black-bone chicken is well known for its nutritional and health-promoting benefits, and the high melanin content in its muscles gives it a distinctive black appearance. Melanin possesses strong free radical scavenging ability, which may influence the antioxidant capacity and flavor characteristics of muscle tissue. Therefore, we conducted RNA sequencing and non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics sequencing on the pectoralis major muscles of Jiangshan black-bone chickens and ordinary chickens (Baier buff chickens), to investigate differences in muscle metabolic regulation between two types of chickens. We detected 88 differentially expressed genes (DEGs) and 124 differential metabolites (DMs), identified enrichment in the "Oxidative phosphorylation", "Glutathione metabolism", and "Melanogenesis" pathways. As a result, genes , , , , , and metabolites "Adenosine diphosphate (ADP)", "Phosphate (Pi)", "Pyrophosphate (PPi)", "Oxidized glutathione (GSSG)", "Spermine", contributed to differences in antioxidant capacity between the pectoralis major muscles of Jiangshan black-bone chickens and Baier buff chickens. Our results indicated that the Jiangshan black-bone chickens could generate more adenosine diphosphate (ADP), thereby enhancing glutathione metabolism and melanin synthesis, which may facilitate the removal of reactive oxygen species (ROS) in muscle tissue. - Source: PubMed
Publication date: 2026/06/10
Zhu LuoyiLi ShiruZhao AyongWang Zhijun - The Yangtze sturgeon (), a critically endangered living fossil whose wild populations are now extinct, faces new challenges to survival in captive breeding. Among these, the emergence of albino and gray color morphs raise fundamental questions about the molecular basis and physiological consequences of pigmentation loss. Here, we integrated histological, transcriptomic, and quantitative PCR to investigate pigmentation variation and associated immune alterations in this species. Histology revealed a complete absence of melanin in albino individuals and marked reduction in gray morphs. Transcriptomic profiling across the three color morphs uncovered a broad downregulation of core melanogenic genes, including , , , , , , , and , indicating impaired melanosome formation, melanin synthesis, and intracellular transport. Notably, pigmentation loss coincided with systematic changes in the expression of immune-related genes: phagosome pathway genes (e.g., , , ) were downregulated, while pro-inflammatory mediators (e.g., , , ) were upregulated, suggesting a transcriptional pattern correlated with reduced expression of pathogen defense-related genes and increased genes associated with inflammation mediators. These findings reveal a mechanistic correlation between melanin deficiency and immune dysfunction in a basal vertebrate lineage, offering the first molecular evidence of an association between albinism and altered immune-related gene expression in sturgeons and highlighting its implications for conservation and captive management. - Source: PubMed
Publication date: 2026/06/15
Wang BinLi YingziSun HanYang FeiJiang KezhenLi YaXiong YixiaoYu ZhaoxiongZhang XuelingLv PeiqiZhang ZhongliangZhang XinLi ZhiqiongZhou BoTang Ni