C-REACTIVE PROTEIN (CRP), Rabbit Liquid
- Known as:
- C-REACTIVE PROTEIN (CRP), Rabbit Liquid
- Catalog number:
- 144-12
- Product Quantity:
- 250 ug
- Category:
- -
- Supplier:
- LeeBio
- Gene target:
- C-REACTIVE PROTEIN (CRP) Rabbit Liquid
Related genes to: C-REACTIVE PROTEIN (CRP), Rabbit Liquid
- Gene:
- ABCG2 NIH gene
- Name:
- ATP binding cassette subfamily G member 2 (Junior blood group)
- Previous symbol:
- -
- Synonyms:
- EST157481, MXR, BCRP, ABCP, CD338
- Chromosome:
- 4q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2019-04-23
- Gene:
- ADIPOQ NIH gene
- Name:
- adiponectin, C1Q and collagen domain containing
- Previous symbol:
- ACDC
- Synonyms:
- ACRP30, AdipoQ, apM1, GBP28, adiponectin
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-26
- Date modifiied:
- 2016-10-05
- Gene:
- BANF1P1 NIH gene
- Name:
- barrier to autointegration factor 1 pseudogene 1
- Previous symbol:
- -
- Synonyms:
- BCRP1, D14S1460, D14S1460E, BCRG1
- Chromosome:
- 14q24.1
- Locus Type:
- pseudogene
- Date approved:
- 2003-04-09
- Date modifiied:
- 2012-04-19
- Gene:
- C1QTNF4 NIH gene
- Name:
- C1q and TNF related 4
- Previous symbol:
- -
- Synonyms:
- CTRP4, ZACRP4
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
- Gene:
- C1QTNF6 NIH gene
- Name:
- C1q and TNF related 6
- Previous symbol:
- -
- Synonyms:
- CTRP6, ZACRP6
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
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guanine nucleotide binding protein alpha inhibiting activity polypeptide 1 (GNAI1) polyclonal antibody"0" Calibrator Matrix, Liquid 20ml Vial"0" Calibrator Matrix, Liquid 20ml Vial"Affordable Gel Doc System with UV, Epi white & white
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- In the cosmetic industry, active ingredients often consist of organic compounds that are hydrophobic, making oil-based formulations impractical. Oil-in-water (O/W) nanoemulsions are used to deliver such ingredients in an aqueous medium. However, creating stable nanoemulsions with uniform size, especially from natural products, poses significant challenges. This study presents the development of micellar O/W nanoemulsions to deliver meroterpenoid-rich fractions from the ethanolic extract of (MES). We systematically investigated the effects of mixing order and chemical compositions on the size and stability of nanoemulsions, enhancing stability with a tri-block copolymer for micellar features. Under optimised conditions, nanoemulsions with a size around 20 nm were prepared. The MES-loaded nanoemulsion effectively inhibited melanin production over multiple cycles, demonstrating increased stability against oxidation. Molecular docking revealed strong binding affinities of MES compounds to tyrosinase-related protein 1 (TYRP1), indicating potential as effective skin-whitening agents. - Source: PubMed
Publication date: 2024/12/30
Siboro Sonita A PSalma Sabrina AufarYuliati FritaRahayu Iresha MuthiaTaek Lim Kwon - Excessive melanin accumulation causes hyperpigmentation, a skin pathophysiology that highlights the need for safe and multifunctional skin-whitening agents. Building on the reported tyrosinase inhibitory potential of phenylthiazole derivatives, a series of compounds was designed and synthesized to investigate the structural determinants of their multi-functional activities. The biological evaluation included mushroom tyrosinase (mTYR) inhibition, as well as anti-melanogenic, anti-inflammatory, and antioxidant assays. Among the series, compound 3c exhibited the most potent multi-functional profile, showing mTYR inhibition (IC = 30.8 ± 2.7 µM) with a mixed-type inhibitory mechanism (K = 20 µM), a 34% reduction in melanin content at 40 µM, significant nitric oxide inhibition (IC = 33.7 ± 2.0 µM), and strong antioxidant activity (SC = 29.0 ± 0.8 µM). Density Functional Theory (DFT) calculations and predicted physicochemical properties indicate that 3c possesses favorable molecular stability and promising potential for skin penetration. Molecular docking and molecular dynamics (MD) simulations further demonstrated that 3c stably occupies the active pocket of human tyrosinase-related protein 1 (TYRP1, PDB ID: 5M8M), forming key interactions with Zn-coordinating residues and maintaining a stable energetic profile. Collectively, these findings indicate that 3c exhibits the most balanced multi-functional activity within the series and holds promise as a lead compound for topical skin-whitening applications. - Source: PubMed
Publication date: 2026/05/12
Xu YangLiang XuhuiHyun Chang-Gu - The Taiwanese loach (Paramisgurnus dabryanus ssp. Taiwanese), known for its nutritional and ornamental qualities, exhibits a rare form of albinism. Specifically, certain individuals display golden-pink eyes and a golden-red body color devoid of blotches, thereby attracting consumers. However, the principal genes regulating this phenotype remain unidentified. Consequently, this study conducted a transcriptome comparative analysis of the skin between wild-type (M) and mutant (N) Taiwanese loaches. A total of 6,152 differentially expressed genes (DEGs) were identified, comprising 2,467 down-regulated and 3,685 up-regulated DEGs in mutant individuals. Additionally, several pigmentation-related genes (mitf, wnt3, mc1r, wnt1, dct, tyrp1, and tyr) were identified. KEGG enrichment analysis of DEGs revealed pathways associated with melanin deposition, including the melanogenesis, tyrosine metabolism, and folate biosynthesis pathways. Eleven DEGs were randomly selected to validate RNA-seq results through qPCR. Furthermore, key genes (tyr, mc1r) were validated through gene knockout, accurately identifying the main gene responsible for color mutation in the Taiwanese loach. This study not only offers new insights into the molecular mechanism underlying abnormal body color in the Taiwanese loach but also demonstrates that gene knockout technology can rapidly produce a large quantity of golden-red loaches, significantly enhancing their economic value. - Source: PubMed
Publication date: 2026/05/11
Li RongyunBai XiaohuiCao XiaojuanHao ShuangLiu KemingLuo ZhangGao JianWang YaoxinZhang YunbangMa LinJiang Jufeng - Radix Polygalae is a traditional Chinese herbal medicine with various pharmacological effects, including improvement of cognitive ability, anti-neurodegenerative property, and antiviral property, among others. Radix Polygalae was also utilized in the treatment of vitiligo in traditional folk clinics, although its mechanism of action remains unclear. This study investigates the potential active ingredients of Radix Polygalae in the treatment of vitiligo. - Source: PubMed
Publication date: 2026/05/04
Zhu LuLiang YixuanJiang LingFu ChuhanDai XixiaGuo HaoranZeng QinghaiHu ShuanghaiChen Jing - The sex-linked barring of chicken feather pattern is a fascinating trait, and it has great application value in chicken breeding by enabling autosexing. In this study, the transcriptome changes in skin follicle tissues from the back (SKs) and crown of the head (SKHs) were explored by RNA-seq in Wenshang Barred chickens during their feather pattern formation. The key genes and signaling pathways regulating sex-linked barring formation in chickens were analyzed. As a result, a total of 2291 and 4496 differentially expressed genes (DEGs) were found in SKs and SKHs, respectively, during barred feather formation. The expression pattern clusters of Profile 6 and Profile 7 were the important and mainstream expression trends of the DEGs. Melanogenesis KEGG pathway and GO terms of melanocyte differentiation, melanosome organization and melanin biosynthetic biological processes were significantly enriched in the DEGs, including the well-known TYR, TYRP1, EDNRB and PMEL genes, clustered in Profile 6 expression pattern. A series of DEGs, including CDKN2A, SFN, CDKN2B and CDK1, were significantly enriched in the cell cycle pathway and were mostly clustered in Profile 7. Protein‒protein interaction (PPI) network analysis revealed TYR, TYRP1, CDKN2A and SFN were the hub genes. It was speculated that CDKN2A may target SFN to regulate the melanocyte cycle arrest, causing the formation of white bands of sex-linked barring. TYR, TYRP1, EDNRB and PMEL genes may play important regulatory roles by melanogenesis pathway in the early growth of black feathers, as well as in the later formation of black stripes. The different expression patterns of SLC45A2, KIT, MC1R, ASIP, DCT and SOX10 in SKs and SKHs may contribute to the different formation processes of barred feather patterns on the head and the back. These results provide new insights into the regulation of sex-linked barred feather patterns in Chinese native chicken and provide a valuable theoretical foundation for future chicken breeding and related efforts. - Source: PubMed
Publication date: 2026/04/16
Xue QianLi GuohuiZhang HuiyongYin JianmeiZhou ChenghaoJiang YixiuJu XingHan Wei