Mouse TU3A Protein ELISA Kit
- Known as:
- Mouse TU3A Protein Enzyme-linked immunosorbent assay test Kit
- Catalog number:
- 201-02-0988
- Product Quantity:
- 96T
- Category:
- Elisa Kits
- Supplier:
- Sunred
- Gene target:
- Mouse TU3A Protein ELISA Kit
Related genes to: Mouse TU3A Protein ELISA Kit
- Gene:
- FAM107A NIH gene
- Name:
- family with sequence similarity 107 member A
- Previous symbol:
- -
- Synonyms:
- DRR1, TU3A
- Chromosome:
- 3p14.3-p14.2
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-17
- Date modifiied:
- 2018-02-13
Related products to: Mouse TU3A Protein ELISA Kit
Related articles to: Mouse TU3A Protein ELISA Kit
- Avian leukosis virus (ALV) causes immunosuppression and tumors, resulting in considerable economic losses in the poultry industry. However, the genetic basis of ALV susceptibility in indigenous breeds remains elusive. Herein, we conducted a genome-wide association study for ALV susceptibility in 259 Wuhua yellow chickens, an indigenous Chinese breed with known disease resistance. ALV infection status was determined by p27 antigen ELISA at 46 weeks of age, with 10 individuals (3.9%) classified as positive. We identified 58 significant SNPs, all located on chromosome 12 and concentrated within a 1.03-Mb region (12.19-13.22 Mb), using SAIGE to account for extreme case‑control imbalance. Gene annotation demonstrated 11 candidate genes, among which FHIT accounted for 44 of the 58 significant SNPs (76%). Additionally, PDHB, PTPRG, FAM3D, and FAM107A were identified as potential candidate genes associated with ALV susceptibility. Notably, conditional analysis confirmed that the lead SNP in FHIT (chr12:12,650,715) is the main driver of this cluster, given that its inclusion as a covariate eliminated all neighboring signals. Functional enrichment showed the citrate cycle as the most considerably enriched pathway, highlighted by PDHB, alongside pyruvate and carbon metabolism. The convergence of tumor suppression (FHIT, FAM107A), metabolic reprogramming (PDHB), and immune/signaling (PTPRG, FAM3D) genes within a single genomic region suggests a potential resistance-associated haplotype block. Our study provides promising candidate genetic markers for breeding ALV-resistant lines and offers novel insights into host-retrovirus interactions beyond traditional immune signaling. - Source: PubMed
Publication date: 2026/06/10
Huang XunheXie TingtingXu YongjieWeng ZhuoxianZhang LiDu Bingwang - Family with sequence similarity 107 member A (FAM107A) has been reported to inhibit cancer cell proliferation and migration and enhance apoptosis; however, to our knowledge, the association between FAM107A and colorectal cancer (CRC) has not been explored. - Source: PubMed
Publication date: 2026/03/18
Liu YueSun JinweiShi YuhuaWang LishengZhang XinyueChen Lizhou - Bladder cancer (BC) continues to be a major public health challenge due to its high recurrence and mortality rates, compounded by difficulties in early detection. Identifying novel genetic biomarkers is crucial for improving diagnosis and therapy. This study integrates machine learning with Mendelian randomization (MR) to identify and validate potential biomarkers for BC. - Source: PubMed
Publication date: 2025/12/03
Xu ChaojieDong YingLi JiouLiao XinhuiZhang ChiLv ChangningLi ChenLiu YuchenYao LinZhou Liqun - To identify the transcriptomic changes induced by dexamethasone (DEX) in trabecular meshwork (TM) and Schlemm's canal endothelial (SCE) cells with RNA sequencing (RNA-seq). - Source: PubMed
Mehrotra SudeepJeanneret HavenPerkumas KristinLiu ReneeLama JyotiHuynh KatieMukundan AnanyaScott HilaryApivatthakakul AtitayaWiggs Janey LSobrin LuciaStamer W DanielSegrè Ayellet V - Exposure to stressful life events is a major risk factor for many psychiatric disorders. The mineralocorticoid receptor (MR) is a key regulator of the hypothalamic-pituitary-adrenal axis, a central stress response component. Stress-related mental disorders, such as anxiety and depression, are associated with MR dysfunction in the brain, but its cell type-specific contributions to emotional behavior and cognitive function remain unclear. - Source: PubMed
Publication date: 2025/11/07
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