Recombinant Human SULT4A1
- Known as:
- Recombinant Human SULT4A1
- Catalog number:
- CF71
- Product Quantity:
- 10ug
- Category:
- -
- Supplier:
- Novoprotein
- Gene target:
- Recombinant Human SULT4A1
Related genes to: Recombinant Human SULT4A1
- Gene:
- SULT4A1 NIH gene
- Name:
- sulfotransferase family 4A member 1
- Previous symbol:
- -
- Synonyms:
- SULTX3, hBR-STL-1
- Chromosome:
- 22q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-14
- Date modifiied:
- 2016-10-05
Related products to: Recombinant Human SULT4A1
Related articles to: Recombinant Human SULT4A1
- Sulfate is a vital nutrient for healthy brain development. More than 90 sulfate-related genes are highly conserved across mammalian species, with 16 of these genes being clinically reportable for adverse brain conditions. To determine the potential involvement of additional sulfate-related genes in human neuropathology, this study curated the spatial and temporal expression patterns of all known sulfate biology genes in the human fetal brain from 8 to 37 post conception weeks (pcw) using data from the BrainSpan database and performed network analysis to cluster sulfate-related genes with genes involved in neurodevelopmental processes. A total of 64 sulfate-related genes were abundantly or moderately expressed in 11 brain regions throughout gestation. Steady state expression was observed for some of these genes from 8 to 37 pcw, including genes that encode sulfotransferases (, ), sulfatases (, , , ), sulfatase modifying enzyme (), key enzymes in amino acid metabolism (, ), sulfate transporter (), as well as genes involved in neurodevelopmental processes (, , , , , ). Between 21-24 weeks, there were numerous clusters of sulfate biology genes with neurodevelopmental genes involved in neuronal migration ( and synaptogenesis (, , , ). At 8-13 and 17-21 pcw, fifteen sulfate genes (, , , , , , , , , , , , , , ) were expressed in the hippocampus and clustered with genes involved in neurogenesis, differentiation and synaptogenesis (, , ). Overall, this study identified 48 sulfate-related genes with moderate/abundant expression in the fetal brain that are coexpressed with genes for neurodevelopmental processes but are not considered in clinical settings. These findings provide information for future studies into the physiological roles of sulfate-related genes that are expressed in the fetal brain. - Source: PubMed
Publication date: 2026/05/08
Vijayakumar PrasidheeSummers Kim MDawson Paul A - Apolipoprotein B (APOB), a structural component of low-density lipoproteins (LDL), has historically been associated with peripheral lipid transport and cardiovascular disease. Recent studies have revealed a link between APOB and Alzheimer's disease (AD), with increased cerebrospinal fluid (CSF) APOB levels correlating with tau pathology. Although APOB is known to be locally expressed in the brain, albeit at very low levels, its function in the central nervous system and contribution to neurodegenerative processes remains poorly understood. To investigate the effects of chronic APOB overexpression on brain molecular homeostasis, we used a transgenic mouse model expressing human APOB-100 and integrated findings with human cohort data to assess its functional relevance to AD pathology. - Source: PubMed
Publication date: 2026/04/02
Aumont-Rodrigue GabrielPoirier AlexandrePicard CynthiaPoirier Judes - The gut microbiome is closely associated with malignant tumors; however the specific mechanisms by which it contributes to the development of lung adenocarcinoma remain unclear. In this study, we performed a two-sample bidirectional Mendelian randomization (MR) analysis to assess the causal relationship between the gut microbiome and lung adenocarcinoma. By identifying single nucleotide polymorphism markers linked to gut microbiome species, we aimed to discover potential biomarkers for lung adenocarcinoma. These findings may offer new insights into the role of the gut microbiome in the prevention and treatment of lung adenocarcinoma. - Source: PubMed
Publication date: 2026/03/18
Yan NuoZhang YangWang SilinHu ShengRuan LianchengWang YunzheFeng WeiqiangXiong WenxunZhang WenxiongWei YipingYao Chuan - Developmental epileptic encephalopathy (DEE) in children presents significant diagnostic and management challenges. Advances in whole-exome sequencing (WES) have enabled the identification of rare genetic variants, offering new insights into these complex conditions. Here, we report a 2.5-year-old girl with refractory epilepsy and DEE, in whom WES revealed a novel homozygous splice-site variant. Although the variant likely contributed to her condition, the later emergence of motor and speech delay in a sibling with the same mutation suggests variable expressivity or age-dependent onset, rather than incomplete penetrance. The patient partially responded to immunotherapy but continued to experience breakthrough seizures and developmental delays, highlighting the challenges in managing such disorders. This case underscores the importance of genetic testing, functional studies, and genetic counseling in the diagnosis and treatment of rare neurodevelopmental disorders. - Source: PubMed
Publication date: 2025/08/29
Bdair MohammadHajjeh OrabiTakhman MuhammadAbukhalil Maram MMilhem FathiAbushama Ahmed J - As typical filter-feeding organisms, bivalve scallops exhibit strong capabilities in accumulating paralytic shellfish toxins (PSTs) from toxic algae, posing risks to public health. To investigate PST-induced molecular responses in the kidney, the major "center" for toxin transformation, a time-course transcriptome analysis of the Yesso Scallop (Patinopecten yessoensis) over six time points (0, 1, 3, 5, 10, and 15 days) after exposure to the PST-producing algae (Alexandrium catenella) were conducted. During the 15 days exposure, PST accumulation in scallop kidneys showed a continuous increase. However, the dominant toxin shifted from the low-toxicity C2 to high-toxicity neoSTX and STX compared to the algal toxin profiles. Transcriptomic analysis revealed that differentially expressed genes (DEGs) were mainly concentrated on the 3rd (629) and 10th day (745), coinciding with significant changes in toxin accumulation patterns. The SLC family was persist up-regulated throughout the exposure period, while the C-type lectin family exhibited biphasic transcriptional expression. Calmodulin was significantly up-regulated on the 15th day, the time point with the highest toxin content and toxicity. Moreover, we identified SULT4A1 as a potential key gene involved in PST biotransformation from low- to high-toxicity derivatives (neoSTX and STX), with its expression significantly associated with these toxins (Pearson's r = 0.52, 0.68). This study provides insights into the molecular mechanisms of shellfish adapt to defense phycotoxins. - Source: PubMed
Publication date: 2025/06/14
Li MoliKong LinglingXun XiaogangZhao LiangChang LirongWang HuizhenBao ZhenminHu XiaoliLiu Pingping